Microwave-Assisted Solid-State Synthesis of Fluorinated Hydroxyapatite
As an important inorganic component of vertebrate bones and teeth, hydroxyapatite (HA) has excellent biocompatibility, bioactivity, osteoconductivity and chemical stability, and can be used as a drug-release carrier and bone tissue engineering repair material. However, when it is used alone, it often presents a few disadvantages such as large brittleness, low fatigue resistance, and easy agglomeration. In this study, to improve its mechanical properties fluorinated hydroxyapatite (FHA) was synthesized by doping fluorine ion in nanocrystalline HA in solid state through microwave sintering of the mixture of HA and MgF2 in the presence of water as an adhesive agent. The X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier-transform infrared spectroscopy (FTIR) analyses were performed to explore the formation mechanism of FHA from HA under microwave irradiation.
KeywordsHydroxyapatite Fluorination Microwave sintering Synthesis Mechanical properties
This work was partially supported by the Fundamental Research Funds for the Central Universities of Central South University under Grant 2018zzts040, the Co-Innovation Center for Clean and Efficient Utilization of Strategic Metal Mineral Resources under Grant 2014-405, the Innovation-Driven Program of Central South University under Grant 2016CXS021, and the Shenghua Lieying Program of Central South University under Grant 502035001.
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