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Cell-Based Therapy for Degenerative Retinal Disease pp 193–216Cite as

Diagnosis and Complementary Examinations

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Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Retinal degenerative diseases cause relentless, progressive loss of vision through a variety of mechanisms, affecting photoreceptors, retinal pigment epithelial cells, and choroidal and/or retinal perfusion. The most sensitive measures of disease severity depend on the primary cell damaged in each retinal degeneration. Visual function measures provide information about how the patient experiences the world and therefore provide clinically meaningful outcome measures of disease activity. Unfortunately, some of the most commonly used tests of visual function, including visual acuity, are insensitive measures of disease severity or progression, while more sensitive functional tests are often variable in patients with retinal degenerative disease. Advanced imaging technology permits evaluation of retinal structure with cellular-level resolution in some cases and provides sensitive, objective measures that complement visual function tests to enable multimodal assessment of retinal degenerative diseases. This chapter outlines measures of visual function and retinal structure that are commonly used to diagnose patients with retinal degenerative disease and monitor disease severity during disease progression and in response to experimental therapies.

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Authors and Affiliations

  1. Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA

    Young Ju Lew & Jacque L. Duncan

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  1. Young Ju Lew
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  2. Jacque L. Duncan
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Correspondence to Jacque L. Duncan .

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Editors and Affiliations

  1. Institute of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Newark, NJ, USA

    Marco A. Zarbin

  2. Wilmer Eye Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA

    Mandeep S. Singh

  3. Department of Surgery School of Medicine & Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain

    Ricardo P. Casaroli-Marano

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Lew, Y.J., Duncan, J.L. (2019). Diagnosis and Complementary Examinations. In: Zarbin, M., Singh, M., Casaroli-Marano, R. (eds) Cell-Based Therapy for Degenerative Retinal Disease . Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-030-05222-5_11

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