Pheromone, Natural Odor and Odorant Reception Suppressing Agent (ORSA) for Insect Control

  • Guoxia Liu
  • Philippe Arnaud
  • Bernard Offmann
  • Jean-François PicimbonEmail author


Odorant-binding proteins (OBPs) are small “bowl-like” globular proteins, highly abundant in the antennae of most insect species. These proteins are believed to mediate reception of odor molecules at the periphery of sensory receptor neurons. Therefore, they may represent crucial targets for becoming new methods of insect pest control by directly interfering with the olfactory acuity of the insect. The current better understanding of molecular mechanisms underlying odor detection and the knowledge about the functional binding sites of OBPs and many other families of binding proteins in various insect species is elucidated here. Such information forms the basis for the synthesis of new inhibitor olfactory compounds (Odorant Reception-Suppressing Agents, ORSAs) to interact specifically with the groups of insect pests.



Heartfelt thanks to Prof. Em. Karl-Ernst Kaissling (Max Planck Institute of Seewiesen, Germany) for inspiration, discussion and most helpful comments on early versions of this manuscript.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Guoxia Liu
    • 1
  • Philippe Arnaud
    • 2
    • 3
  • Bernard Offmann
    • 2
  • Jean-François Picimbon
    • 1
    • 4
    Email author
  1. 1.Biotechnology Research CenterShandong Academy of Agricultural SciencesJinanPeople’s Republic of China
  2. 2.Protein Engineering and Functionality UnitUniversity of NantesNantesFrance
  3. 3.Centre Universitaire Franco-Malaisien & Service de Coopération Universitaire et Scientifique, Ambassade de France en MalaisieKuala LumpurMalaysia
  4. 4.School of BioengineeringQILU University of TechnologyJinanPeople’s Republic of China

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