Skip to main content
SpringerLink
Log in
Book cover

Clinical Care and Rehabilitation in Head and Neck Cancer pp 351–375Cite as

Oral Considerations for the Head and Neck Cancer Patient

  • Chapter
  • First Online:

  • 1058 Accesses

Abstract

Oral oncology/maxillofacial prosthodontics is the branch of dentistry that specializes in the prevention and treatment of the oral morbidities associated with treatment of cancer, as well as the oral prosthetic rehabilitation following tumor ablative surgery. Treatment of cancer in the head and neck can have substantial posttreatment oral morbidities, decreasing the overall quality of life of survivors. Minimizing or reducing these oral challenges becomes increasingly important as the survivability of these cancers improves, particularly those in the oropharynx. Relatively minor interventions, such as pre-treatment oral examination, judicious/strategic dental extractions, patient education, and daily fluoride treatments, can have a dramatic impact in the prevention or reduction of mucositis, osteoradionecrosis, and postradiation dental caries. This chapter will describe practical approaches for the preventing, recognizing, and treating the oral sequelae associated with cancer therapy. This chapter will also describe the most common oral prostheses using after tumor ablative surgery and their indication for use.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Notes

  1. 1.

    National Institute of Dental and Craniofacial Research (2016).

  2. 2.

    The glossary of prosthodontic terms (2005).

References

  • Annane, D., Depondt, J., Aubert, P., Villart, M., Gehanno, P., Gajdos, P., & Chevret, S. (2004). Hyperbaric oxygen therapy for radionecrosis of the jaw: A randomized, placebo-controlled, double-blind trial from the ORN96 study group. Journal of Clinical Oncology, 22(24), 4893–4900. https://doi.org/10.1200/JCO.2004.09.006

    Article  PubMed  Google Scholar 

  • Aramany, M. A. (1978a). Basic principles of obturator design for partially edentulous patients. Part I: Classification. Journal of Prosthetic Dentistry, 40(5), 554–557.

    Article  CAS  Google Scholar 

  • Aramany, M. A. (1978b). Basic principles of obturator design for partially edentulous patients. Part II: Design principles. Journal of Prosthetic Dentistry, 40(6), 656–662.

    Article  CAS  Google Scholar 

  • Barnhart, G. W. (1960). A new material and technic in the art of somato-prosthesis. Journal of Dental Research, 39, 836–844. https://doi.org/10.1177/00220345600390041001

    Article  CAS  PubMed  Google Scholar 

  • Beadle, B. M., Liao, K. P., Chambers, M. S., Elting, L. S., Buchholz, T. A., Kian Ang, K., … Guadagnolo, B. A. (2013). Evaluating the impact of patient, tumor, and treatment characteristics on the development of jaw complications in patients treated for oral cancers: A SEER-Medicare analysis. Head & Neck, 35(11), 1599–1605. https://doi.org/10.1002/hed.23205

    Article  Google Scholar 

  • Beech, N., Porceddu, S., & Batstone, M. D. (2016). Preradiotherapy dental extractions and health-related quality of life. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology, 122(6), 672–679. https://doi.org/10.1016/j.oooo.2016.07.020

    Article  Google Scholar 

  • Bertram, F., Bertram, S., Rudisch, A., & Emshoff, R. (2018). Assessment of location of the mandibular canal: Correlation between panoramic and cone beam computed tomography measurements. International Journal of Prosthodontics. https://doi.org/10.11607/ijp.5430

  • Beumer, J., Silverman, S. J., & Benak, S. B. (1972). Hard and soft tissue necroses following radiation therapy for oral cancer. Journal of Prosthetic Dentistry, 27(6), 640–644.

    Article  Google Scholar 

  • Bodey, G. P., Buckley, M., Sathe, Y. S., & Freireich, E. J. (1966). Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Annals of Internal Medicine, 64(2), 328–340.

    Article  CAS  PubMed  Google Scholar 

  • Braga, F. P., Lemos Junior, C. A., Alves, F. A., & Migliari, D. A. (2011). Acupuncture for the prevention of radiation-induced xerostomia in patients with head and neck cancer. Brazilian Oral Research, 25(2), 180–185.

    Article  PubMed  Google Scholar 

  • Brennan, M. T., Treister, N. S., Sollecito, T. P., Schmidt, B. L., Patton, L. L., Mohammadi, K., … Lalla, R. V. (2017). Dental disease before radiotherapy in patients with head and neck cancer: Clinical registry of dental outcomes in head and neck Cancer patients. Journal of the American Dental Association, 148(12), 868–877. https://doi.org/10.1016/j.adaj.2017.09.011

    Article  PubMed  Google Scholar 

  • Buchbinder, D., Currivan, R. B., Kaplan, A. J., & Urken, M. L. (1993). Mobilization regimens for the prevention of jaw hypomobility in the radiated patient: A comparison of three techniques. Journal of Oral and Maxillofacial Surgery, 51(8), 863–867.

    Article  CAS  PubMed  Google Scholar 

  • Buglione, M., Cavagnini, R., Di Rosario, F., Maddalo, M., Vassalli, L., Grisanti, S., … Magrini, S. M. (2016). Oral toxicity management in head and neck cancer patients treated with chemotherapy and radiation: Xerostomia and trismus (Part 2). Literature review and consensus statement. Critical Reviews in Oncology/Hematology, 102, 47–54. https://doi.org/10.1016/j.critrevonc.2016.03.012

    Article  PubMed  Google Scholar 

  • Chambers, M. S., Garden, A. S., Rosenthal, D., Ahamad, A., Schwartz, D. L., Blanco, A. I., … Weber, R. S. (2005). Intensity-modulated radiotherapy: Is xerostomia still prevalent? Current Oncology Reports, 7(2), 131–136.

    Article  PubMed  Google Scholar 

  • Chambers, M. S., Toth, B. B., Martin, J. W., Fleming, T. J., & Lemon, J. C. (1995). Oral and dental management of the cancer patient: Prevention and treatment of complications. Supportive Care in Cancer, 3(3), 168–175.

    Article  CAS  PubMed  Google Scholar 

  • Chuka, R., Abdullah, W., Rieger, J., Nayar, S., Seikaly, H., Osswald, M., & Wolfaardt, J. (2017). Implant utilization and time to prosthetic rehabilitation in conventional and advanced fibular free flap reconstruction of the maxilla and mandible. International Journal of Prosthodontics, 30(3), 289–294. https://doi.org/10.11607/ijp.5161

    Article  Google Scholar 

  • Ciancio, S. (1994). Expanded and future uses of mouthrinses. Journal of the American Dental Association, 125(Suppl 2), 29S–32S.

    Article  PubMed  Google Scholar 

  • Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999). Bacterial biofilms: A common cause of persistent infections. Science, 284(5418), 1318–1322.

    Article  CAS  PubMed  Google Scholar 

  • Darveau, R. P., Tanner, A., & Page, R. C. (1997). The microbial challenge in periodontitis. Periodontology 2000, 14, 12–32.

    Article  CAS  PubMed  Google Scholar 

  • Davies, A., & Epstein, J. (2010). Oral complications of Cancer and its management. Oxford, U.K.: OUP Oxford.

    Book  Google Scholar 

  • Delanian, S., Depondt, J., & Lefaix, J. L. (2005). Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: A phase II trial. Head & Neck, 27(2), 114–123. https://doi.org/10.1002/hed.20121

    Article  Google Scholar 

  • Delanian, S., & Lefaix, J. L. (2002). Complete healing of severe osteoradionecrosis with treatment combining pentoxifylline, tocopherol and clodronate. British Journal of Radiology, 75(893), 467–469. https://doi.org/10.1259/bjr.75.893.750467

    Article  CAS  Google Scholar 

  • Delanian, S., & Lefaix, J. L. (2004). The radiation-induced fibroatrophic process: Therapeutic perspective via the antioxidant pathway. Radiotherapy and Oncology, 73(2), 119–131. https://doi.org/10.1016/j.radonc.2004.08.021

    Article  PubMed  Google Scholar 

  • Deng, J., Jackson, L., Epstein, J. B., Migliorati, C. A., & Murphy, B. A. (2015). Dental demineralization and caries in patients with head and neck cancer. Oral Oncology, 51(9), 824–831. https://doi.org/10.1016/j.oraloncology.2015.06.009

    Article  PubMed  Google Scholar 

  • Dijkstra, P. U., Huisman, P. M., & Roodenburg, J. L. (2006). Criteria for trismus in head and neck oncology. International Journal of Oral and Maxillofacial Surgery, 35(4), 337–342. https://doi.org/10.1016/j.ijom.2005.08.001

    Article  CAS  PubMed  Google Scholar 

  • Dijkstra, P. U., Kalk, W. W., & Roodenburg, J. L. (2004). Trismus in head and neck oncology: A systematic review. Oncology, 40(9), 879–889. https://doi.org/10.1016/j.oraloncology.2004.04.003

    Article  CAS  Google Scholar 

  • Duchnay, M., Tenenbaum, H., Wood, R., Raziee, H. R., Shah, P. S., & Azarpazhooh, A. (2015). Interventions for preventing osteoradionecrosis of the jaws in people receiving head and neck radiotherapy. Cochrane Database of Systematic Reviews, (2), CD011559. https://doi.org/10.1002/14651858

  • Engelmeier, R. L. (1987). A dental protocol for patients receiving radiation therapy for cancer of the head and neck. Special Care in Dentistry, 7(2), 54–58.

    Article  CAS  PubMed  Google Scholar 

  • Epstein, J., Ransier, A., Lunn, R., & Spinelli, J. (1994). Enhancing the effect of oral hygiene with the use of a foam brush with chlorhexidine. Oral Surgery, Oral Medicine, and Oral Pathology, 77(3), 242–247.

    Article  CAS  PubMed  Google Scholar 

  • Epstein, J. B., Wong, F. L., & Stevenson-Moore, P. (1987). Osteoradionecrosis: Clinical experience and a proposal for classification. Journal of Oral and Maxillofacial Surgery, 45(2), 104–110.

    Article  CAS  PubMed  Google Scholar 

  • Farmer, J. C., Jr., Shelton, D. L., Angelillo, J. D., Bennett, P. D., & Hudson, W. R. (1978). Treatment of radiation-induced tissue injury by hyperbaric oxygen. The Annals of Otology, Rhinology, and Laryngology, 87(5 Pt 1), 707–715. https://doi.org/10.1177/000348947808700517

    Article  PubMed  Google Scholar 

  • Fleming, T. J. (1990). Oral tissue changes of radiation-oncology and their management. Dental Clinics of North America, 34(2), 223–237.

    CAS  PubMed  Google Scholar 

  • Flink, H. (2007). Studies on the prevalence of reduced salivary flow rate in relation to general health and dental caries, and effect of iron supplementation. Swedish Dental Journal, 192, 3–50. 52.

    Google Scholar 

  • Fukuda, M., Takahashi, T., Nagai, H., & Iino, M. (2004). Implant-supported edentulous maxillary obturators with milled bar attachments after maxillectomy. Journal of Oral and Maxillofacial Surgery, 62(7), 799–805.

    Article  PubMed  Google Scholar 

  • Furness, S., Bryan, G., McMillan, R., & Worthington, H. V. (2013). Interventions for the management of dry mouth: Non-pharmacological interventions. Cochrane Database of Systematic Reviews, 8, CD009603. https://doi.org/10.1002/14651858.CD009603.pub2

    Article  Google Scholar 

  • Gerritsen, A. E., Allen, P. F., Witter, D. J., Bronkhorst, E. M., & Creugers, N. H. (2010). Tooth loss and oral health-related quality of life: A systematic review and meta-analysis. Health and Quality of Life Outcomes, 8, 126. https://doi.org/10.1186/1477-7525-8-126

    Article  PubMed  PubMed Central  Google Scholar 

  • The glossary of prosthodontic terms. (2005). Journal of Prosthetic Dentistry, 94(1), 10–92.

    Article  Google Scholar 

  • Gold, K. A., Neskey, M., & William, W. N., Jr. (2013). The role of systemic treatment before, during, and after definitive treatment. Otolaryngologic Clinics of North America, 46(4), 645–656. https://doi.org/10.1016/j.otc.2013.04.005

    Article  PubMed  PubMed Central  Google Scholar 

  • Goldstein, M., Maxymiw, W. G., Cummings, B. J., & Wood, R. E. (1999). The effects of antitumor irradiation on mandibular opening and mobility: A prospective study of 58 patients. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, 88(3), 365–373.

    Article  CAS  Google Scholar 

  • Gritz, E. R. (1988). Cigarette smoking: The need for action by health professionals. CA: A Cancer Journal for Clinicians, 38(4), 194–212.

    CAS  Google Scholar 

  • Gunn, G. B., & Frank, S. J. (2013). Advances in radiation oncology for the management of oropharyngeal tumors. Otolaryngologic Clinics of North America, 46(4), 629–643. https://doi.org/10.1016/j.otc.2013.04.004

    Article  PubMed  Google Scholar 

  • Harnacke, D., Mitter, S., Lehner, M., Munzert, J., & Deinzer, R. (2012). Improving oral hygiene skills by computer-based training: A randomized controlled comparison of the modified bass and the Fones techniques. PLoS One, 7(5), e37072. https://doi.org/10.1371/journal.pone.0037072

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Haumschild, M. S., & Haumschild, R. J. (2009). The importance of oral health in long-term care. Journal of the American Medical Directors Association, 10(9), 667–671. https://doi.org/10.1016/j.jamda.2009.01.002

    Article  PubMed  Google Scholar 

  • Karr, R. A., & Kramer, D. C. (1992). You can treat the chemotherapy patient. Texas Dental Journal, 109(6), 15–20.

    CAS  PubMed  Google Scholar 

  • Keene, H. J., & Fleming, T. J. (1987). Prevalence of caries-associated microflora after radiotherapy in patients with cancer of the head and neck. Oral Surgery, Oral Medicine, and Oral Pathology, 64(4), 421–426.

    Article  CAS  PubMed  Google Scholar 

  • Kent, M. L., Brennan, M. T., Noll, J. L., Fox, P. C., Burri, S. H., Hunter, J. C., & Lockhart, P. B. (2006). Radiation-induced trismus in head and neck cancer patients. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 102(3), 305–309.

    Article  Google Scholar 

  • Kielbassa, A. M., Hellwig, E., & Meyer-Lueckel, H. (2006). Effects of irradiation on in situ remineralization of human and bovine enamel demineralized in vitro. Caries Research, 40(2), 130–135. https://doi.org/10.1159/000091059

    Article  CAS  PubMed  Google Scholar 

  • Krakoff, I. H. (1991). Cancer chemotherapeutic and biologic agents. CA: A Cancer Journal for Clinicians, 41(5), 264–278.

    CAS  Google Scholar 

  • Kutsch, V. K. (2014). Dental caries: An updated medical model of risk assessment. Journal of Prosthetic Dentistry, 111(4), 280–285. https://doi.org/10.1016/j.prosdent.2013.07.014

    Article  Google Scholar 

  • Lambrecht, M., Mercier, C., Geussens, Y., & Nuyts, S. (2013). The effect of a supersaturated calcium phosphate mouth rinse on the development of oral mucositis in head and neck cancer patients treated with (chemo)radiation: A single-center, randomized, prospective study of a calcium phosphate mouth rinse + standard of care versus standard of care. Supportive Care in Cancer, 21(10), 2663–2670. https://doi.org/10.1007/s00520-013-1829-0

    Article  PubMed  Google Scholar 

  • Langland, O. E., Langlais, R. P., Morris, C. R., & Preece, J. W. (1980). Panoramic radiographic survey of dentists participating in ADA health screening programs: 1976, 1977, and 1978. Journal of the American Dental Association, 101(2), 279–282.

    Article  CAS  PubMed  Google Scholar 

  • Lefkoff, M. H., Beck, F. M., & Horton, J. E. (1995). The effectiveness of a disposable tooth cleansing device on plaque. Journal of Periodontology, 66(3), 218–221. https://doi.org/10.1902/jop.1995.66.3.218

    Article  CAS  PubMed  Google Scholar 

  • LeVeque, F. G., Montgomery, M., Potter, D., Zimmer, M. B., Rieke, J. W., Steiger, B. W., … Muscoplat, C. C. (1993). A multicenter, randomized, double-blind, placebo-controlled, dose-titration study of oral pilocarpine for treatment of radiation-induced xerostomia in head and neck cancer patients. Journal of Clinical Oncology, 11(6), 1124–1131. https://doi.org/10.1200/JCO.1993.11.6.1124

    Article  CAS  PubMed  Google Scholar 

  • Lieshout, H. F., & Bots, C. P. (2014). The effect of radiotherapy on dental hard tissue--a systematic review. Clinical Oral Investigations, 18(1), 17–24. https://doi.org/10.1007/s00784-013-1034-z

    Article  CAS  PubMed  Google Scholar 

  • Lindquist, S. F., Hickey, A. J., & Drane, J. B. (1978). Effect of oral hygiene on stomatitis in patients receiving cancer chemotherapy. Journal of Prosthetic Dentistry, 40(3), 312–314.

    Article  CAS  Google Scholar 

  • Liu, R. P., Fleming, T. J., Toth, B. B., & Keene, H. J. (1990). Salivary flow rates in patients with head and neck cancer 0.5 to 25 years after radiotherapy. Oral Surgery, Oral Medicine, and Oral Pathology, 70(6), 724–729.

    Article  CAS  PubMed  Google Scholar 

  • Logemann, J. A., Smith, C. H., Pauloski, B. R., Rademaker, A. W., Lazarus, C. L., Colangelo, L. A., … Newman, L. A. (2001). Effects of xerostomia on perception and performance of swallow function. Head & Neck, 23(4), 317–321.

    Article  CAS  Google Scholar 

  • Lund, T. W., & Cohen, J. I. (1993). Trismus appliances and indications for use. Quintessence International, 24(4), 275–279.

    CAS  PubMed  Google Scholar 

  • Lyons, A., Osher, J., Warner, E., Kumar, R., & Brennan, P. A. (2014). Osteoradionecrosis--a review of current concepts in defining the extent of the disease and a new classification proposal. British Journal of Oral and Maxillofacial Surgery, 52(5), 392–395. https://doi.org/10.1016/j.bjoms.2014.02.017

    Article  PubMed  Google Scholar 

  • Lyons, A. J., Nixon, I., Papadopoulou, D., & Crichton, S. (2013). Can we predict which patients are likely to develop severe complications following reconstruction for osteoradionecrosis? British Journal of Oral and Maxillofacial Surgery, 51(8), 707–713. https://doi.org/10.1016/j.bjoms.2013.08.017

    Article  PubMed  Google Scholar 

  • Magrini, S. M., Buglione, M., Corvo, R., Pirtoli, L., Paiar, F., Ponticelli, P., … Grisanti, S. (2016). Cetuximab and radiotherapy versus Cisplatin and radiotherapy for locally advanced head and neck cancer: A randomized Phase II trial. Journal of Clinical Oncology, 34(5), 427–435. https://doi.org/10.1200/JCO.2015.63.1671

    Article  CAS  PubMed  Google Scholar 

  • Mallick, S., Benson, R., & Rath, G. K. (2016). Radiation induced oral mucositis: A review of current literature on prevention and management. European Archives of Oto-Rhino-Laryngology, 273(9), 2285–2293. https://doi.org/10.1007/s00405-015-3694-6

    Article  PubMed  Google Scholar 

  • Maloney, G. E., Mehta, N., Forgione, A. G., Zawawi, K. H., Al-Badawi, E. A., & Driscoll, S. E. (2002). Effect of a passive jaw motion device on pain and range of motion in TMD patients not responding to flat plane intraoral appliances. Cranio, 20(1), 55–66.

    Article  PubMed  Google Scholar 

  • Mandel, I. D. (1989). The role of saliva in maintaining oral homeostasis. Journal of the American Dental Association, 119(2), 298–304.

    Article  CAS  PubMed  Google Scholar 

  • Mansfield, M. J., Sanders, D. W., Heimbach, R. D., & Marx, R. E. (1981). Hyperbaric oxygen as an adjunct in the treatment of osteoradionecrosis of the mandible. Journal of Oral Surgery, 39(8), 585–589.

    CAS  PubMed  Google Scholar 

  • Marciani, R. D., & Ownby, H. E. (1986). Osteoradionecrosis of the jaws. Journal of Oral and Maxillofacial Surgery, 44(3), 218–223.

    Article  CAS  PubMed  Google Scholar 

  • Marinho, V. C. (2014). Applying prescription-strength home-use and professionally applied topical fluoride products may benefit people at high risk for caries - the American Dental Association (ADA) 2013 clinical practice guideline recommendations. The Journal of Evidence-Based Dental Practice, 14(3), 120–123. https://doi.org/10.1016/j.jebdp.2014.07.011

    Article  PubMed  Google Scholar 

  • Marinho, V. C., Higgins, J. P., Logan, S., & Sheiham, A. (2003). Topical fluoride (toothpastes, mouthrinses, gels or varnishes) for preventing dental caries in children and adolescents. Cochrane Database of Systematic Reviews, (4), CD002782. https://doi.org/10.1002/14651858.CD002782

  • Mariotti, A. (1999). Dental plaque-induced gingival diseases. Annals of Periodontology, 4(1), 7–19. https://doi.org/10.1902/annals.1999.4.1.7

    Article  CAS  PubMed  Google Scholar 

  • Martin, J. W., Austin, J. R., Chambers, M. S., Lemon, J. C., & Toth, B. B. (1994). Postoperative care of the maxillectomy patient. ORL-Head and Neck Nursing, 12(3), 15–20.

    CAS  PubMed  Google Scholar 

  • Marunick, M., & Tselios, N. (2004). The efficacy of palatal augmentation prostheses for speech and swallowing in patients undergoing glossectomy: A review of the literature. Journal of Prosthetic Dentistry, 91(1), 67–74. https://doi.org/10.1016/S0022391303007352

    Article  Google Scholar 

  • Marx, R. E. (1983). Osteoradionecrosis: A new concept of its pathophysiology. Journal of Oral and Maxillofacial Surgery, 41(5), 283–288.

    Article  CAS  PubMed  Google Scholar 

  • Marx, R. E., & Johnson, R. P. (1987). Studies in the radiobiology of osteoradionecrosis and their clinical significance. Oral Surgery, Oral Medicine, and Oral Pathology, 64(4), 379–390.

    Article  CAS  PubMed  Google Scholar 

  • Marx, R. E., Johnson, R. P., & Kline, S. N. (1985). Prevention of osteoradionecrosis: A randomized prospective clinical trial of hyperbaric oxygen versus penicillin. Journal of the American Dental Association, 111(1), 49–54.

    Article  CAS  PubMed  Google Scholar 

  • McCord, J. F., & Michelinakis, G. (2004). Systematic review of the evidence supporting intra-oral maxillofacial prosthodontic care. The European Journal of Prosthodontic and Restorative Dentistry, 12(3), 129–135.

    Google Scholar 

  • Meng, Z., Garcia, M. K., Hu, C., Chiang, J., Chambers, M., Rosenthal, D. I., … Cohen, L. (2012a). Randomized controlled trial of acupuncture for prevention of radiation-induced xerostomia among patients with nasopharyngeal carcinoma. Cancer, 118(13), 3337–3344. https://doi.org/10.1002/cncr.26550

    Article  PubMed  Google Scholar 

  • Meng, Z., Garcia, M. K., Hu, C., Chiang, J., Chambers, M., Rosenthal, D. I., … Cohen, L. (2012b). Sham-controlled, randomised, feasibility trial of acupuncture for prevention of radiation-induced xerostomia among patients with nasopharyngeal carcinoma. European Journal of Cancer, 48(11), 1692–1699. https://doi.org/10.1016/j.ejca.2011.12.030

    Article  PubMed  Google Scholar 

  • Mercadante, V., Al Hamad, A., Lodi, G., Porter, S., & Fedele, S. (2017). Interventions for the management of radiotherapy-induced xerostomia and hyposalivation: A systematic review and meta-analysis. Oral Oncology, 66, 64–74. https://doi.org/10.1016/j.oraloncology.2016.12.031

    Article  PubMed  Google Scholar 

  • Migliorati, C., Hewson, I., Lalla, R. V., Antunes, H. S., Estilo, C. L., Hodgson, B., … Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral, Oncology. (2013). Systematic review of laser and other light therapy for the management of oral mucositis in cancer patients. Supportive Care in Cancer, 21(1), 333–341. https://doi.org/10.1007/s00520-012-1605-6

  • Monahan, T., & Fisher, J. A. (2010). Benefits of “observer effects”: Lessons from the field. Qualitative Research, 10(3), 357–376. https://doi.org/10.1177/1468794110362874

    Article  PubMed  Google Scholar 

  • National Institute of Dental and Craniofacial Research. (2016). Oral complications of cancer treatment: What the dental team can do. http://www.nidcr.nih.gov/oralhealth/Topics/CancerTreatment/OralComplicationsCancerOral.htm. Accessed 5 Oct 2016.

  • Nicolatou-Galitis, O., Sarri, T., Bowen, J., Di Palma, M., Kouloulias, V. E., Niscola, P., … Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral, Oncology. (2013). Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients. Supportive Care in Cancer, 21(11), 3179–3189. https://doi.org/10.1007/s00520-013-1847-y

  • Notani, K., Yamazaki, Y., Kitada, H., Sakakibara, N., Fukuda, H., Omori, K., & Nakamura, M. (2003). Management of mandibular osteoradionecrosis corresponding to the severity of osteoradionecrosis and the method of radiotherapy. Head & Neck, 25(3), 181–186. https://doi.org/10.1002/hed.10171

    Article  Google Scholar 

  • Okay, D. J., Genden, E., Buchbinder, D., & Urken, M. (2001). Prosthodontic guidelines for surgical reconstruction of the maxilla: A classification system of defects. Journal of Prosthetic Dentistry, 86(4), 352–363. https://doi.org/10.1067/mpr.2001.119524

    Article  CAS  Google Scholar 

  • Panwar, A., Batra, R., Lydiatt, W. M., & Ganti, A. K. (2014). Human papilloma virus positive oropharyngeal squamous cell carcinoma: A growing epidemic. Cancer Treatment Reviews, 40(2), 215–219. https://doi.org/10.1016/j.ctrv.2013.09.006

    Article  PubMed  Google Scholar 

  • Peterson, D. E., & D’Ambrosio, J. A. (1994). Nonsurgical management of head and neck cancer patients. Dental Clinics of North America, 38(3), 425–445.

    CAS  PubMed  Google Scholar 

  • Peterson, D. E., Ohrn, K., Bowen, J., Fliedner, M., Lees, J., Loprinzi, C., … Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology. (2013). Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy. Supportive Care in Cancer, 21(1), 327–332. https://doi.org/10.1007/s00520-012-1562-0

  • Pezzuto, F., Buonaguro, L., Caponigro, F., Ionna, F., Starita, N., Annunziata, C., … Tornesello, M. L. (2015). Update on head and neck cancer: Current knowledge on epidemiology, risk factors, molecular features and novel therapies. Oncology, 89(3), 125–136. https://doi.org/10.1159/000381717

    Article  PubMed  Google Scholar 

  • Poyato-Ferrera, M., Segura-Egea, J. J., & Bullon-Fernandez, P. (2003). Comparison of modified bass technique with normal toothbrushing practices for efficacy in supragingival plaque removal. International Journal of Dental Hygiene, 1(2), 110–114. https://doi.org/10.1034/j.1601-5037.2003.00018.x

    Article  CAS  PubMed  Google Scholar 

  • Pytynia, K. B., Dahlstrom, K. R., & Sturgis, E. M. (2014). Epidemiology of HPV-associated oropharyngeal cancer. Oral Oncology, 50(5), 380–386. https://doi.org/10.1016/j.oraloncology.2013.12.019

    Article  PubMed  PubMed Central  Google Scholar 

  • Quinn, B. (2013). Efficacy of a supersaturated calcium phosphate oral rinse for the prevention and treatment of oral mucositis in patients receiving high-dose cancer therapy: A review of current data. European Journal of Cancer Care (Engl), 22(5), 564–579. https://doi.org/10.1111/ecc.12073

    Article  CAS  Google Scholar 

  • Raber-Durlacher, J. E., von Bultzingslowen, I., Logan, R. M., Bowen, J., Al-Azri, A. R., Everaus, H., … Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral, Oncology. (2013). Systematic review of cytokines and growth factors for the management of oral mucositis in cancer patients. Supportive Care in Cancer, 21(1), 343–355. https://doi.org/10.1007/s00520-012-1594-5

  • Rankin, K. V., Jones, D. L., & Redding, S. W. (2008). Oral health in cancer therapy. A guide for health care professionals (3rd ed.). Dallas, TX/Austin, TX: Baylor Oral Health Foundation/Cancer Prevention and Research Institute of Texas.

    Google Scholar 

  • Rapidis, A. D., Dijkstra, P. U., Roodenburg, J. L., Rodrigo, J. P., Rinaldo, A., Strojan, P., … Ferlito, A. (2015). Trismus in patients with head and neck cancer: Etiopathogenesis, diagnosis and management. Clinical Otolaryngology, 40(6), 516–526. https://doi.org/10.1111/coa.12488

    Article  CAS  PubMed  Google Scholar 

  • Rivero, J. A., Shamji, O., & Kolokythas, A. (2017). Osteoradionecrosis: A review of pathophysiology, prevention and pharmacologic management using pentoxifylline, alpha-tocopherol, and clodronate. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology, 124(5), 464–471. https://doi.org/10.1016/j.oooo.2017.08.004

    Article  Google Scholar 

  • Rosenberg, S. W. (1990). Oral care of chemotherapy patients. Dental Clinics of North America, 34(2), 239–250.

    CAS  PubMed  Google Scholar 

  • Rouse, P. B. (1970). The role of physical therapists in support of maxillofacial patients. Journal of Prosthetic Dentistry, 24(2), 193–197.

    Article  CAS  Google Scholar 

  • Ruggiero, S. L., Mehrotra, B., Rosenberg, T. J., & Engroff, S. L. (2004). Osteonecrosis of the jaws associated with the use of bisphosphonates: A review of 63 cases. Journal of Oral and Maxillofacial Surgery, 62(5), 527–534.

    Article  PubMed  Google Scholar 

  • Schmalz, G., Kiehl, K., Schmickler, J., Rinke, S., Schmidt, J., Krause, F., … Ziebolz, D. (2018). Correction to: No difference between manual and different power toothbrushes with and without specific instructions in young, oral healthy adults-results of a randomized clinical trial. Clinical Oral Investigations, 22(3), 1609. https://doi.org/10.1007/s00784-017-2200-5

    Article  PubMed  Google Scholar 

  • Schusterman, M. A., Reece, G. P., Miller, M. J., & Harris, S. (1992). The osteocutaneous free fibula flap: Is the skin paddle reliable? Plastic and Reconstructive Surgery, 90(5), 787–793. discussion 794-788.

    Article  CAS  PubMed  Google Scholar 

  • Schweiger, J. W. (1987). Oral complications following radiation therapy: A five-year retrospective report. Journal of Prosthetic Dentistry, 58(1), 78–82.

    Article  CAS  Google Scholar 

  • Scott, B., Butterworth, C., Lowe, D., & Rogers, S. N. (2008). Factors associated with restricted mouth opening and its relationship to health-related quality of life in patients attending a maxillofacial oncology clinic. Oral Oncology, 44(5), 430–438.

    Article  CAS  PubMed  Google Scholar 

  • Shulman, D. H., Shipman, B., & Willis, F. B. (2008). Treating trismus with dynamic splinting: A cohort, case series. Advances in Therapy, 25(1), 9–16. https://doi.org/10.1007/s12325-008-0007-0

    Article  PubMed  Google Scholar 

  • Simard, E. P., Torre, L. A., & Jemal, A. (2014). International trends in head and neck cancer incidence rates: Differences by country, sex and anatomic site. Oral Oncology, 50(5), 387–403. https://doi.org/10.1016/j.oraloncology.2014.01.016

    Article  PubMed  Google Scholar 

  • Simcock, R., Fallowfield, L., Monson, K., Solis-Trapala, I., Parlour, L., Langridge, C., … Committee, A. S. (2013). ARIX: A randomised trial of acupuncture v oral care sessions in patients with chronic xerostomia following treatment of head and neck cancer. Annals of Oncology, 24(3), 776–783. https://doi.org/10.1093/annonc/mds515

    Article  CAS  PubMed  Google Scholar 

  • Sonis, S. T. (2007). Pathobiology of oral mucositis: Novel insights and opportunities. Journal of Supportive Oncology, 5(9 Suppl 4), 3–11.

    CAS  PubMed  Google Scholar 

  • Sonis, S. T. (2009). Mucositis: The impact, biology and therapeutic opportunities of oral mucositis. Oral Oncology, 45(12), 1015–1020. https://doi.org/10.1016/j.oraloncology.2009.08.006

    Article  CAS  PubMed  Google Scholar 

  • Sonis, S. T. (2017). The chicken or the egg? Changes in oral microbiota as cause or consequence of mucositis during radiation therapy. eBioMedicine, 18, 7–8. https://doi.org/10.1016/j.ebiom.2017.03.017

    Article  PubMed  PubMed Central  Google Scholar 

  • Store, G., & Boysen, M. (2000). Mandibular osteoradionecrosis: Clinical behaviour and diagnostic aspects. Clinical Otolaryngology and Allied Sciences, 25(5), 378–384.

    Article  CAS  PubMed  Google Scholar 

  • Store, G., Eribe, E. R., & Olsen, I. (2005). DNA-DNA hybridization demonstrates multiple bacteria in osteoradionecrosis. International Journal of Oral and Maxillofacial Surgery, 34(2), 193–196. https://doi.org/10.1016/j.ijom.2004.06.010

    Article  CAS  PubMed  Google Scholar 

  • Sturgis, E. M., & Cinciripini, P. M. (2007). Trends in head and neck cancer incidence in relation to smoking prevalence: An emerging epidemic of human papillomavirus-associated cancers? Cancer, 110(7), 1429–1435. https://doi.org/10.1002/cncr.22963

    Article  PubMed  Google Scholar 

  • Teichgraeber, J., Larson, D. L., Castaneda, O., & Martin, J. W. (1984). Skin grafts in intraoral reconstruction. A new stenting method. Archives of Otolaryngology, 110(7), 463–467.

    Article  CAS  PubMed  Google Scholar 

  • Tejwani, A., Wu, S., Jia, Y., Agulnik, M., Millender, L., & Lacouture, M. E. (2009). Increased risk of high-grade dermatologic toxicities with radiation plus epidermal growth factor receptor inhibitor therapy. Cancer, 115(6), 1286–1299. https://doi.org/10.1002/cncr.24120

    Article  CAS  PubMed  Google Scholar 

  • Toljanic, J. A., & Saunders, V. W., Jr. (1984). Radiation therapy and management of the irradiated patient. Journal of Prosthetic Dentistry, 52(6), 852–858.

    Article  CAS  Google Scholar 

  • Toth, B. B., Chambers, M. S., & Fleming, T. C. (1996). Prevention and management of oral complications associated with cancer therapies: Radiotherapy/chemotherapy. Texas Dental Journal, 113(6), 23–29.

    CAS  PubMed  Google Scholar 

  • Toth, B. B., Chambers, M. S., Fleming, T. J., Lemon, J. C., & Martin, J. W. (1995). Minimizing oral complications of cancer treatment. Oncology (Williston Park), 9(9), 851–858. discussion 858, 863-856.

    CAS  Google Scholar 

  • Toth, B. B., Martin, J. W., Chambers, M. S., Robinson, K. A., & Andersson, B. S. (1998). Oral candidiasis: A morbid sequela of anticancer therapy. Texas Dental Journal, 115(6), 24–29.

    CAS  PubMed  Google Scholar 

  • Tumerdem-Ulug, B., Kuran, I., Ozden, B. C., Mete, O., Kemikler, G., Aktas, S., & Calik, B. (2011). Does hyperbaric oxygen administration before or after irradiation decrease side effects of irradiation on implant sites? Annals of Plastic Surgery, 67(1), 62–67. https://doi.org/10.1097/SAP.0b013e3181e6cfa4

    Article  CAS  PubMed  Google Scholar 

  • Vigarios, E., Epstein, J. B., & Sibaud, V. (2017). Oral mucosal changes induced by anticancer targeted therapies and immune checkpoint inhibitors. Supportive Care in Cancer, 25(5), 1713–1739. https://doi.org/10.1007/s00520-017-3629-4

    Article  PubMed  Google Scholar 

  • Walker, M. P., Wichman, B., Cheng, A. L., Coster, J., & Williams, K. B. (2011). Impact of radiotherapy dose on dentition breakdown in head and neck cancer patients. Practical Radiation Oncology, 1(3), 142–148. https://doi.org/10.1016/j.prro.2011.03.003

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang, F., Huang, W., Zhang, C., Sun, J., Qu, X., & Wu, Y. (2017). Functional outcome and quality of life after a maxillectomy: A comparison between an implant supported obturator and implant supported fixed prostheses in a free vascularized flap. Clinical Oral Implants Research, 28(2), 137–143. https://doi.org/10.1111/clr.12771

    Article  PubMed  Google Scholar 

  • Weyant, R. J., Tracy, S. L., Anselmo, T. T., Beltran-Aguilar, E. D., Donly, K. J., Frese, W. A., … American Dental Association Council on Scientific Affairs Expert Panel on Topical Fluoride Caries Preventive, A. (2013). Topical fluoride for caries prevention: Executive summary of the updated clinical recommendations and supporting systematic review. Journal of the American Dental Association, 144(11), 1279–1291.

    Article  PubMed  Google Scholar 

  • Wijbenga, J. G., Schepers, R. H., Werker, P. M., Witjes, M. J., & Dijkstra, P. U. (2016). A systematic review of functional outcome and quality of life following reconstruction of maxillofacial defects using vascularized free fibula flaps and dental rehabilitation reveals poor data quality. Journal of Plastic, Reconstructive & Aesthetic Surgery, 69(8), 1024–1036. https://doi.org/10.1016/j.bjps.2016.05.003

    Article  Google Scholar 

  • Yaacob, M., Worthington, H. V., Deacon, S. A., Deery, C., Walmsley, A. D., Robinson, P. G., & Glenny, A. M. (2014). Powered versus manual toothbrushing for oral health. Cochrane Database of Systematic Reviews, (6), CD002281. https://doi.org/10.1002/14651858.CD002281.pub3

  • Zemnick, C., Woodhouse, S. A., Gewanter, R. M., Raphael, M., & Piro, J. D. (2007). Rapid prototyping technique for creating a radiation shield. Journal of Prosthetic Dentistry, 97(4), 236–241. https://doi.org/10.1016/j.prosdent.2007.02.005

    Article  Google Scholar 

  • Zhu, X. X., Yang, X. J., Chao, Y. L., Zheng, H. M., Sheng, H. F., Liu, H. Y., … Zhou, H. W. (2017). The potential effect of oral microbiota in the prediction of mucositis during radiotherapy for nasopharyngeal carcinoma. eBioMedicine, 18, 23–31. https://doi.org/10.1016/j.ebiom.2017.02.002

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Head and Neck Surgery – Section of Oral Oncology & Maxillofacial Prosthodontics, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA

    Richard C. Cardoso & Mark S. Chambers

Authors
  1. Richard C. Cardoso
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mark S. Chambers
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Richard C. Cardoso .

Editor information

Editors and Affiliations

  1. Department of Otolaryngology Head and Neck Surgery and School of Communication Sciences & Disorders , Western University, London, ON, Canada

    Philip C. Doyle

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Cardoso, R.C., Chambers, M.S. (2019). Oral Considerations for the Head and Neck Cancer Patient. In: Doyle, P. (eds) Clinical Care and Rehabilitation in Head and Neck Cancer. Springer, Cham. https://doi.org/10.1007/978-3-030-04702-3_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-04702-3_21

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-04701-6

  • Online ISBN: 978-3-030-04702-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation