Abstract
The use of nutraceuticals in equine medicine is rapidly growing into a global multibillion-dollar industry. With the introduction of Dietary Supplement Health and Education (DSHEA) legislation in 1994, the regulation of nutraceuticals for animals has become rather vague but was partially rescued by the formation of the National Animal Supplements Council (NASC) in 2002. In equine practice, nutraceuticals are commonly used as performance enhancers as well as joint supplements. In both instances, research in humans as well as horses has been of critical importance. Lameness in horses is one of the most important conditions impacting their usefulness, and nutraceuticals are used commonly in its treatment. Products containing glucosamine and chondroitin sulfate have been shown to be effective with some level of scientific support. There are many others, like undenatured type II collagen, manganese, antioxidants, and vitamin C, which have also been employed with varying levels of success. As performance enhancers, l-carnitine, creatine, branched-chain amino acids, and HMB have all been used, with HMB showing promise. In spite of the initial euphoria, it is a challenging time for the nutraceutical industry to generate quality clinical data to support efficacy and safety claims on its products to ensure sustained growth.
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References
Agar C, Gemmill R, Hollands T et al (2016) The use of nutritional supplements in dressage and eventing horses. Vet Rec Open 3:e000154
Bagchi D, Misner B, Bagchi M et al (2002) Effects of orally administered undenatured type II collagen against arthritic inflammatory disease: a mechanistic exploration. Int J Clin Pharmacol Res 22:101–110
Becque MD, Lochmann JD, Melrose DR (2000) Effects of oral creatine supplementation on muscular strength and body composition. Med Sci Sports Exer 32:654–658
Blomstrand E, Ek S, Newsholme EA (1996) Influence of ingesting a solution of branched-chain amino acids on plasma and muscle concentrations of amino acids during prolonged submaximal exercise. Nutrition 12:485–490
Casini L, Gatta D, Magni L et al (2000) Effect of prolonged branched-chain amino acid supplementation on metabolic response to anaerobic exercise in Standardbreds. J Equine Vet Sci 20:120–123
Chan PS, Caron JP, Rosa GJM et al (2005) Glucosamine and chondroitin sulphate regulate gene expression and synthesis of nitric oxide and prostaglandin E2 in articular cartilage explants. Osteoarthr Cartil 13:387–394
Crandell K, Duren S (2001) Nutraceuticals: what are they and do they work? In: Pagan JD (ed) Advances in equine nutrition, vol II. Nottingham University Press, Nottingham, pp 29–36
Davis JM (1995) Carbohydrates, branched-chain amino acids, and endurance: the central fatigue hypothesis. Int J Sport Nutr 5:S29–S38
DeFelice SL (1995) The nutraceutical revolution: Its impact on food industry R&D. Trends Food Sci Technol 6:59–61
Du J, White N, Eddington ND (2004) The bioavailability and pharmacokinetics of glucosamine hydrochloride and chondroitin sulphate after oral and intravenous single dose administration in the horse. Biopharm Drug Dispos 25:109–116
Eddington ND, Du J, White N (2001) Evidence of the oral absorption of chondroitin sulphate as determined by total disaccharide content after oral and intravenous administration to horses. Proc Annu Convention AAEP 47:326–328
Farris JW, Hinchcliff KW, McKeever KH et al (1998) Effect of tryptophan and of glucose on exercise capacity of horses. J Appl Physiol 85:807–816
Fenton JL, Chlebek-Brown KA, Peters TL et al (2000) Glucosamine HCl reduces equine articular cartilage degradation in explant culture. Osteoarthr Cartil 8:258–265
Gupta RC (2016) Nutraceuticals in arthritis. In: Gupta RC (ed) Nutraceuticals: efficacy, safety and toxicity. Academic/Elsevier, Amsterdam, pp 161–176
Gupta RC, Canerdy TD, Skaggs P et al (2009) Therapeutic efficacy of undenatured type-II collagen (UC-II) in comparison to glucosamine and chondroitin in arthritic horses. J Vet Pharmacol Ther 32:577–584
Hanson RR, Smalley LR, Huff GK et al (1997) Oral treatment with a glucosamine-chondroitin sulfate compound for degenerative joint disease in horses: 25 cases. Equine Pract 19:16–21
Huang A, Owen K (2012) Role of supplementary L-carnitine in exercise and exercise recovery. Med Sport Sci 59:135–142
Laverty S, Sandy JD, Celeste C et al (2005) Synovial fluid levels and serum pharmacokinetics in a large animal model following treatment with oral glucosamine at clinically relevant doses. Arthritis Rheum 52:181–191
Lopez Vaz A (1982) Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients. Curr Med Res Opin 8:145–149
May K, Gupta RC, Miller J et al (2015) Therapeutic efficacy and safety evaluation of a novel chromium supplement (Crominex® +3-) in moderately arthritic horses. Jacobs J Vet Sci Res 2(1):014
Mikulski T, Dabrowski J, Hilgier W et al (2015) Effects of supplementation with branched chain amino acids and ornithine aspartate on plasma ammonia and central fatigue during exercise in healthy men. Folia Neuropathol 53:377–386
Nissen S, Fuller J, Rathmacher J (1997) β-hydroxy β-methylbutyrate (HMB) supplementation in training horses. Metabolic Technologies Bulletin, Ames (Cited by Crandell and Duren 2001)
Ostaszewski P, Kowalska A, Szarska E et al (2012) Effect of β-hydroxy-β-methylbutyrate and γ-oryzanol on blood biochemical markers in exercising Thoroughbred race horses. J Equine Vet Sci 32:542–551
Rahimi MH, Mohammadi H, Eshaghi H et al (2018) The effects of beta-hydroxy-methylbutyrate supplementation on recovery following exercise-induced muscle damage: a systemic review and meta-analysis. J Am Coll Nutr 20:1–10
Sewell DA, Harris RC (1995) Effect of creatine supplementation in the Thoroughbred horse. Equine Vet J 18:239–242
Stefanon B, Bettini C, Guggia P (2000) Administration of branched-chain amino acids to standardbred horses in training. J Equine Vet Sci 20:115–119
Teixeira FA, Araujo AL, Ramalho LO et al (2016) Oral creatine supplementation on performance of Quarter Horses used in barrel racing. J Anim Physiol Anim Nutr 100:513–519
Van de Water E, Oosterlinck M, van Weeren PR et al (2016) The effect of two nutraceuticals on inflammation and biomarkers of cartilage metabolism in equine synovial fluid after experimentally induced acute synovitis. Equine Vet J 48(Suppl 49):7 (Abstract)
Wagenmakers A (1999) Nutritional supplements: effects on exercise performance and metabolism. In: Lamb D, Murray R (eds) Perspectives in exercise science and sports medicine. The metabolic basis of performance in exercise and sport. Indiana Cooper Publishing, Carmel, pp 207–260
Zeyner A, Harmeyer J (1999) Metabolic functions of L-carnitine and its effects as feed additive in horses. A review. Arch Tieremahr 52:115–138
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Sankaranarayanan, A. (2019). Nutraceuticals in Equine Medicine. In: Gupta, R., Srivastava, A., Lall, R. (eds) Nutraceuticals in Veterinary Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-04624-8_45
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