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Autism in Boys and Girls, Women and Men Throughout the Lifespan

  • Patricia van Wijngaarden-CremersEmail author
Chapter

Abstract

Autism Spectrum Disorder (ASD) is a clinical syndrome. ASD is not a distinct condition but the extreme of a continuum that goes from “normality” to “autistic conditions”. In this chapter, the huge differences in clinical expression, gender differences, as well as differences as development progresses will be discussed. To start with, we will look into the notion of developmental psychopathology in which, along with the intrinsic gender factor, the external interaction with the environment plays an important role. Then we will look closely into the different clinical expressions on the different dimensions, to subsequently look into the diagnostic difficulties that lead to late detection in women and high functioning individuals. To finally see which consequences these findings have on our diagnostic assessment, clinical management and families of those with ASD.

Keywords

Autism Spectrum Disorder (ASD) Gender differences Brain development Phenotype Genotype 

References

  1. American Psychiatric Association: Diagnostic and statistical manual III (1981) DSM III-R (1987) DSM IV (1994) and DSM 5 (2013).Google Scholar
  2. Asperger, H. (1944). Die autistischen psychopathen im kindersalter. Archly für Psychiatrie und Nervenkrankheiten, 117(1), 76–136.Google Scholar
  3. Baird, G., Douglas, H. R., & Murphy, M. S. (2011). Recognising and diagnosing autism in children and young people: Summary of NICE guidance. BMJ, 343, 130–136.Google Scholar
  4. Baron-Cohen, S. (2009, March). Autism: The empathizing-systemizing (E-S) theory. Annals of the New York Academy of Sciences, 1156(1), 68–80.Google Scholar
  5. Beadle-Brown, J., Murphy, G., Wing, L., Gould, J., Shah, A., & Holmes, N. (2002, June). Changes in social impairment for people with intellectual disabilities: A follow-up of the Camberwell cohort. Journal of Autism and Developmental Disorders, 32(3), 195–206.Google Scholar
  6. Begeer, S., Mandell, D., Wijnker-Holmes, B., Venderbosch, S., Rem, D., Stekelenburg, F., et al. (2013). Sex differences in the timing of identification among children and adults with autism spectrum disorders. Journal of Autism and Developmental Disorders, 43(5), 1151–1156.PubMedGoogle Scholar
  7. BMJ. (2016). 353, i3028.Google Scholar
  8. Brody, L. R. (1999). Gender, emotion, and the family. Cambridge, MA: Harvard University Press.Google Scholar
  9. Byers, E. S., Nichols, S., & Voyer, S. D. (2013a). Challenging stereotypes: Sexual functioning of single adults with high functioning autism spectrum disorder. Journal of Autism and Developmental Disorders, 43(11), 2617–2627.PubMedGoogle Scholar
  10. Byers, E. S., Nichols, S., Voyer, S. D., & Reilly, G. (2013b). Sexual well-being of a community sample of high-functioning adults on the autism spectrum who have been in a romantic relationship. Autism, 17(4), 418–433.PubMedGoogle Scholar
  11. Cicchetti, D. (2016). Developmental psychopathology (3rd ed., Vol. 4, 4656 pages). Hoboken: Wiley.Google Scholar
  12. Dawson, G. (2008). Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder. Development and Psychopathology, 20(3), 775–803.PubMedGoogle Scholar
  13. de Vries, A. L., Noens, I. L., Cohen-Kettenis, P. T., van Berckelaer-Onnes, I. A., & Doreleijers, T. A. (2010). Autism spectrum disorders in gender dysphoric children and adolescents. Journal of Autism and Developmental Disorders, 40(8), 930–936.PubMedPubMedCentralGoogle Scholar
  14. Fombonne, E. (2009). Epidemiology of pervasive developmental disorders. Pediatric Research, 65(6), 591–598.PubMedGoogle Scholar
  15. Giarelli, E., Wiggins, L. D., Rice, C. E., Levy, S. E., Kirby, R. S., Pinto-Martin, J., et al. (2010). Sex differences in the evaluation and diagnosis of autism spectrum disorders among children. Disability and Health Journal, 3(2), 107–116.PubMedGoogle Scholar
  16. Goel, N., Workman, J. L., Lee, T. T., Innala, L., & Viau, V. (2014). Sex differences in the HPA axis. Comprehensive Physiology, 4(3), 1121–1155.PubMedGoogle Scholar
  17. Green, J., Charman, T., Pickles, A., Wan, M. W., Elsabbagh, M., Slonims, V., et al. (2015). Parent-mediated intervention versus no intervention for infants at high risk of autism: A parallel, single-blind, randomised trial. Lancet Psychiatry, 2(2), 133–140.PubMedPubMedCentralGoogle Scholar
  18. Hampson, D. R., & Blatt, G. J. (2015). Autism spectrum disorders and neuropathology of the cerebellum. Frontiers in Neuroscience, 9, 420.PubMedPubMedCentralGoogle Scholar
  19. Holtmann, M., Bolte, S., & Poustka, F. (2007). Autism spectrum disorders: Sex differences in autistic behaviour domains and coexisting psychopathology. Developmental Medicine and Child Neurology, 49(5), 361–366.PubMedGoogle Scholar
  20. Kanne, S. M., Abbacchi, A. M., & Constantino, J. N. (2009). Multi-informant ratings of psychiatric symptom severity in children with autism spectrum disorders: The importance of environmental context? Journal of Autism and Developmental Disorders, 39(6), 856–864.PubMedPubMedCentralGoogle Scholar
  21. Kanner, L. (1943). Autistic disturbances of affective contact. Nervous Child, 2, 217–250.Google Scholar
  22. Kopp, S., & Gillberg, C. (1992). Girls with social deficits and learning problems: Autism, atypical Asperger syndrome or a variant of these conditions. European Child and Adolescent Psychiatry, 1(2), 89–99.PubMedGoogle Scholar
  23. Lai, M. C., Lombardo, M. V., Pasco, G., Ruigrok, A. N., Wheelwright, S. J., Sadek, S. A., et al. (2011). A behavioral comparison of male and female adults with high functioning autism spectrum conditions. PLoS One, 6(6), e20835.PubMedPubMedCentralGoogle Scholar
  24. Lord, C., & Jones, R. M. (2012). Annual research review: Re-thinking the classification of autism spectrum disorders. Journal of Child Psychology and Psychiatry, 53(5), 490–509.PubMedGoogle Scholar
  25. Lugnegård, T., Hallerbäck, M. U., & Gillberg, C. (2011). Psychiatric comorbidity in young adults with a clinical diagnosis of Asperger syndrome. Research in Developmental Disabilities, 32(5), 1910–1917.PubMedGoogle Scholar
  26. McLennan, J. D., Lord, C., & Schopler, E. (1993). Sex differences in higher functioning people with autism. Journal of Autism and Developmental Disorders, 23(2), 217–227.PubMedGoogle Scholar
  27. NICE Guideline on Autism in Adults. (2012). ASD in Adults. http://guidance.nice.org.uk/CG142.
  28. Nilsson, E. W., Gillberg, C., Carina Gillberg, I., & Råstam, M. (1999). Ten-year follow-up of adolescent-onset anorexia nervosa: Personality disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 38(11), 1389–1395.PubMedGoogle Scholar
  29. Ozonoff, S., Iosif, A. M., Baguio, F., Cook, I. C., Hill, M. M., Hutman, T., et al. (2010). A prospective study of the emergence of early behavioral signs of autism. Journal of the American Academy of Child and Adolescent Psychiatry, 49(3), 256–266, e251–e252.Google Scholar
  30. Ragunath, P. K., Chitra, R., Mohammad, S., & Abhinand, P. A. (2011). A systems biological study on the comor-bidity of autism spectrum disorders and bipolar disorder. Bioinformation, 7(3), 102–106.PubMedPubMedCentralGoogle Scholar
  31. Rajendran, G., & Mitchell, P. (2007). Cognitive theories of autism. Developmental Review, 27(2), 224–260.Google Scholar
  32. Rivet, T. T., & Matson, J. L. (2011). Review of gender differences in core symptomatology in autism spectrum disorders. Research in Autism Spectrum Disorders, 5(3), 957–976.Google Scholar
  33. Rosenberg, R. E., Kaufmann, W. E., Law, J. K., & Law, P. A. (2011). Parent report of community psychiatric comorbid diagnoses in autism spectrum disorders. Autism Research and Treatment, 2011, 405849.Google Scholar
  34. Russell, G., Steer, C., & Golding, J. (2011). Social and demographic factors that influence the diagnosis of autistic spectrum disorders. Journal of Social Psychiatry and Psychiatric Epidemiology, 46(12), 1283–1293.Google Scholar
  35. Siklos, S., & Kerns, K. A. (2007). Assessing the diagnostic experiences of a small sample of parents of children with autism spectrum disorders. Research in Developmental Disabilities, 28(1), 9–22.Google Scholar
  36. Simonoff, E., Pickles, A., Charman, T., Chandler, S., Lucas, T., & Baird, G. (2008). Psychiatric disorders in children with autism spectrum disorders: Prevalence, comorbidity and associated factors in population-derived sample. Journal of the American Academy of Child and Adolescent Psychiatry, 47(8), 921–929.PubMedGoogle Scholar
  37. Van Steensel, J. J. A., Bögels, S. M., & Perrins, S. (2011). Anxiety disorders in children and adolescents with autistic spectrum disorders: A meta-analysis. Clinical Child and Family Psychology Review, 14(3), 302–317.PubMedPubMedCentralGoogle Scholar
  38. van Wijngaarden-Cremers, P. J. M., van Eeten, E., Groen, W. B., van Deurzen, P. A., Oosterling, I. J., & van der Gaag, R. J. (2014). Gender and age differences in the core triad of impairments in autism spectrum disorders: A systematic review and meta-analysis. Journal of Autism and Developmental Disorders, 44(3), 627–635.PubMedGoogle Scholar
  39. van Wijngaarden-Cremers, P. J. M. (2015). Gender: Comorbidity and autism. Ph.D. thesis, Radboud University Nijmegen. repository.ubn.ru.nl/bitstream/handle/2066/142158/142158.pdf.
  40. Wan, M. W., Green, J., Elsabbagh, M., Johnson, M., Charman, T., & Plummer, F. (2012). Parent-infant interaction in infant siblings at risk of autism. Research in Developmental Disabilities, 33(3), 924–932.PubMedGoogle Scholar
  41. Wing, L., & Gould, J. (1979). Severe impairments of social interaction and associated abnormalities in children: Epidemiology and classification. Journal of Autism and Developmental Disorders, 9(1), 11–29.PubMedGoogle Scholar
  42. Wing, L. (1996). Autistic spectrum disorders. BMJ: British Medical Journal, 312(7027), 327ΓÇô328.PubMedGoogle Scholar
  43. Wolff, D., & Wolff, S. (1995). Loners: The life path of unusual children. London: Routledge.Google Scholar

Copyright information

© The Author(s) 2019

Authors and Affiliations

  1. 1.Department of Expertise of Developmental DisordersSCOS DimenceDeventerThe Netherlands
  2. 2.Department of PsychiatryRadboud University NijmegenNijmegenThe Netherlands

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