Modern Molecular Biology Technologies and Higher Usability of Ancient Knowledge of Medicinal Plants for Treatment of Human Diseases

  • Venkatesh VaidyanathanEmail author
  • Vijay Naidu
  • Anower Jabed
  • Khanh Tran
  • Prasanna Kallingappa
  • Chi Hsiu-Juei Kao
  • Alice Wang
  • Nishi Karunasinghe
  • Radha Pallati
  • Gareth Marlow
  • Shaik Noor Ahmad
  • Lynnette R. Ferguson


Medicinal plants and plant products have been used by humans since the ancient times. Medicinal plants find wide usage in developed as well as in developing countries worldwide even till date, and yet there is not much crosstalk between the researchers of molecular medicine and/or diagnostics and practitioners and users of alternative medicines. In this chapter, we have tried to connect the dots and identify certain simple yet well-established molecular technologies that we believe should be employed in order to identify the function of the genes and the effect of the bioactive compound(s) in medicinal plant(s) to treat patients with various chronic diseases such as various cancers or enhance conventional treatment for better patient outcome.


SNP genotyping PLINK CRISPR/Cas9 miRNA Phylogenetic tree GeCKO 



Aldo-keto reductase family 1 member C3


Benjamini and Hochberg False Discovery Rate


BLOcks SUbstitution Matrix


Bonferroni correction


Dynamic allele-specific hybridization


Deoxyribonucleic acid


Deoxynucleotide diphosphates


Deoxynucleotide triphosphates




Genomic DNA


Genome-scale CRISPR knock-out


Genome-wide association studies


Homology-directed repair


Homeobox B8


Hardy-Weinberg equilibrium


Identical by state


Linkage disequilibrium


Multiple alignment using fast Fourier transform


Minimum evolution


Maximum likelihood


Maximum parsimony


Messenger ribonucleic acid


Neighbour joining


Non-homologous end joining


Point accepted mutations


Prostate cancer


Prostate-specific antigen


Restriction fragment length polymorphism


Ribonucleic acid


RNA interference


Single guide RNA


Short hairpin RNA


Single nucleotide polymorphism


Transcription activator-like effector nuclease


Unweighted pair group method with arithmetic means


Zinc finger nuclease


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Venkatesh Vaidyanathan
    • 1
    • 2
    Email author
  • Vijay Naidu
    • 3
  • Anower Jabed
    • 4
  • Khanh Tran
    • 4
  • Prasanna Kallingappa
    • 4
    • 5
  • Chi Hsiu-Juei Kao
    • 1
    • 2
  • Alice Wang
    • 1
    • 2
  • Nishi Karunasinghe
    • 2
  • Radha Pallati
    • 1
  • Gareth Marlow
    • 6
  • Shaik Noor Ahmad
    • 7
  • Lynnette R. Ferguson
    • 1
    • 2
  1. 1.Discipline of Nutrition and Dietetics, FM & HSUniversity of AucklandAucklandNew Zealand
  2. 2.Auckland Cancer Society Research CentreAucklandNew Zealand
  3. 3.School of Engineering, Computer and Mathematical SciencesAuckland University of TechnologyAucklandNew Zealand
  4. 4.Department of Molecular Medicine and Pathology, FM & HSUniversity of AucklandAucklandNew Zealand
  5. 5.Vernon Jenson Unit, FM & HSUniversity of AucklandAucklandNew Zealand
  6. 6.Experimental Cancer Medicine CentreCardiff UniversityCardiffUK
  7. 7.Department of Genetic MedicineKing Abdulaziz UniversityJeddahSaudi Arabia

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