Abstract
Plant-based foods satisfy more than 70% of the human energy and nutrition requirements. However, such foods may be contaminated by heavy metal(loid)s. The dietary exposure to excessive levels of these contaminants is detrimental to human health. In this chapter, we have reviewed the reported contamination levels of arsenic (As), cadmium (Cd), lead (Pb), mercury (Hg) and nickel (Ni) in cereals, vegetables, fruits, nuts, pulses and plant oils. The reported concentrations in different plant-based foods were up to 2.9 mg As kg−1, 24 mg Cd kg−1, 61 mg Pb kg−1, 0.10 mg Hg kg−1 and 506 mg Ni kg−1. Concentrations of the studied contaminants in plant oils were within permissible levels in all the listed studies. Moreover, Hg was within permissible levels in all the studies. However, some samples of vegetables, fruits, cereals, pulses and nuts were reported to be contaminated by As, Cd, Pb and Ni to levels toxic to humans. The contamination levels in plant-based foods were related to contamination of agricultural soils, irrigation waters, atmosphere and crop inputs. The occurrence of contaminated plant-based foods is more common in the densely populated developing and underdeveloped countries in the world. Wastewater treatment, soil remediation and control of the emission of air pollutants have become increasingly important for sustainable agriculture. In the absence of effective remediation, food plants should not be grown in contaminated areas or near the sources of contamination.
Keywords
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Ahmed K, Shaheen N, Islam S et al (2016) A comprehensive assessment of arsenic in commonly consumed foodstuffs to evaluate the potential health risk in Bangladesh. Sci Total Environ 544:125–133. https://doi.org/10.1016/j.scitotenv.2015.11.133
Akhtar S, Naz S, Sultan MT et al (2010) Physico-chemical attributes and Heavy metal content of mangoes (Mangifera indica L.) cultivated in different regions of Pakistan. Pak J Bot 42:2691–2702
Akinyele IO, Shokunbi OS (2015) Concentrations of Mn, Fe, Cu, Zn, Cr, Cd, Pb, Ni in selected Nigerian tubers, legumes and cereals and estimates of the adult daily intakes. Food Chem 173:702–708. https://doi.org/10.1016/j.foodchem.2014.10.098
Alam MGM, Snow ET, Tanaka T (2003) Arsenic and heavy metal contamination of vegetables grown. Sci Total Environ 308:83–96
Alfvén T, Elinder C, Carlsson MD et al (2000) Low-level cadmium exposure and osteoporosis. J Bone Miner Res 15:1579–1586
Ali I (2012) New generation adsorbents for water treatment. Chem Rev 112:5073–5091. https://doi.org/10.1021/cr300133d
Ali MHH, Al-Qahtani KM (2012) Assessment of some heavy metals in vegetables, cereals and fruits in Saudi Arabian markets. Egypt J Aquat Res 38:31–37. https://doi.org/10.1016/j.ejar.2012.08.002
Al-Jaboobi M, Zouahri A, Tijane M et al (2014) Evaluation of heavy metals pollution in groundwater, soil and some vegetables irrigated with wastewater in the Skhirat region “Morocco”. J Mater Environ Sci 5:961–966
Alloway BJ (1995) Soil processes and the behaviour of metals. In: Alloway BJ (ed) Heavy metals in soils. Blackie Academic and Professional, Glasgow, pp 11–37
Almås ÅR, Lombnæs P, Sogn TA, Mulder J (2006) Speciation of Cd and Zn in contaminated soils assessed by DGT-DIFS, and WHAM/Model VI in relation to uptake by spinach and ryegrass. Chemosphere 62:1647–1655. https://doi.org/10.1016/j.chemosphere.2005.06.020
Almås ÅR, Lofts S, Mulder J, Tipping E (2007) Solubility of major cations and Cu, Zn and Cd in soil extracts of some contaminated agricultural soils near a zinc smelter in Norway: modelling with a multisurface extension of WHAM. Eur J Soil Sci 58:1074–1086. https://doi.org/10.1111/j.1365-2389.2007.00894.x
Amery F, Degryse F, Cheyns K et al (2008) The UV-absorbance of dissolved organic matter predicts the fivefold variation in its affinity for mobilizing Cu in an agricultural soil horizon. Eur J Soil Sci 59:1087–1095
Angeli JK, Cruz Pereira CA, de Oliveira Faria T et al (2013) Cadmium exposure induces vascular injury due to endothelial oxidative stress: the role of local angiotensin II and COX-2. Free Radic Biol Med 65:838–848. https://doi.org/10.1016/j.freeradbiomed.2013.08.167
Angelova VR, Ivanova RV, Delibaltova VA, Ivanov KI (2011) Use of sorghum crops for in situ phytoremediation of polluted soils. J Agric Sci Technol 1:693–702
Anke M, Groppel B, Gruen M, et al (1980) The influence of arsenic deficiency on growth, reproductiveness, life expectancy and health of goats. In: Spurenelement symposium, pp 25–32
Antoniadis V (2008) Sewage sludge application and soil properties effects on short-term zinc leaching in soil columns. Water Air Soil Pollut 190:35–43. https://doi.org/10.1007/s11270-007-9577-8
Apostoli P, Corulli A, Carta P et al (2005) Lead and blood pressure. G Ital Med Lav Ergon 27:22–32. [Article in Italian]
ATSDR (2017) Toxic substances portal—arsenic. Agency for Toxic Substances and Disease Registry, Atlanta, GA. https://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=22&tid=3. Accessed 30 Jan 2017
Bagdatlioglu N, Nergiz C, Ergonul PG (2010) Heavy metal levels in leafy vegetables and some selected fruits. J Consum Prot Food Saf 5:421–428. https://doi.org/10.1007/s00003-010-0594-y
Bailey K, Fry RC (2014) Long-term health consequences of prenatal arsenic exposure: links to the genome and the epigenome. Rev Environ Health 29:9–12. https://doi.org/10.1515/reveh-2014-0006
Barros L, Carvalho AM, Morais JS, Ferreira ICFR (2010) Strawberry-tree, blackthorn and rose fruits: detailed characterisation in nutrients and phytochemicals with antioxidant properties. Food Chem 120:247–254. https://doi.org/10.1016/j.foodchem.2009.10.016
Bati K, Mogobe O, Masamba WRL (2016) Concentrations of some trace elements in vegetables sold at Maun Market, Botswana. J Food Res 6:69. https://doi.org/10.5539/jfr.v6n1p69
Beattie J, Crozier A, Duthie G (2005) Potential health benefits of berries. Curr Nutr Food Sci 1:71–86. https://doi.org/10.2174/1573401052953294
Beccaloni E, Vanni F, Beccaloni M, Carere M (2013) Concentrations of arsenic, cadmium, lead and zinc in homegrown vegetables and fruits: estimated intake by population in an industrialized area of Sardinia, Italy. Microchem J 107:190–195. https://doi.org/10.1016/j.microc.2012.06.012
Bempah CK, Buah-kwofie A, Tutu AO et al (2011) Pesticide residues and heavy metals levels in some selected fruits and vegetables from Ghanaian markets. Food Sci 39:4964–4972
Benincasa C, Lewis J, Perri E et al (2007) Determination of trace element in Italian virgin olive oils and their characterization according to geographical origin by statistical analysis. Anal Chim Acta 585:366–370. https://doi.org/10.1016/j.aca.2006.12.040
Beshah FH, Porter NA, Wrigley R et al (2015) Soil residuals and plant uptake of Cu and Zn from biosolids applied to a clay loam soil under field conditions in Victoria, Australia. Soil Res 53:807–814
Bhattacharya P, Samal AC, Majumdar J, Santra SC (2010) Arsenic contamination in rice, wheat, pulses, and vegetables: a study in an arsenic affected area of West Bengal, India. Water Air Soil Pollut 213:3–13. https://doi.org/10.1007/s11270-010-0361-9
Bilos C, Colombo JC, Skorupka CN, Presa MJR (2001) Sources, distribution and variability of airborne trace metals in La Plata City area, Argentina. Environ Pollut 111:149–158
Blomhoff R, Carlsen MH, Andersen LF, Jacobs DR (2006) Health benefits of nuts: potential role of antioxidants. Br J Nutr 96:S52. https://doi.org/10.1017/BJN20061864
Boeing H, Bechthold A, Bub A et al (2012) Critical review: vegetables and fruit in the prevention of chronic diseases. Eur J Nutr 51:637–663. https://doi.org/10.1007/s00394-012-0380-y
Bonacker D, Stoiber T, Wang M et al (2004) Genotoxicity of inorganic mercury salts based on disturbed microtubule function. Arch Toxicol 78:575–583
Bothe H (2011) Plants in Heavy Metal Soils. In: Sherameti I, Varma A (eds) Detoxification of heavy metals. Springer, Berlin, pp 35–57
Bradl HB (2004) Adsorption of heavy metal ions on soils and soils constituents. J Colloid Interface Sci 277:1–18. https://doi.org/10.1016/j.jcis.2004.04.005
Bukhari IH, Ramzan M, Riaz M et al (2013) Determination of trace heavy metals in different varieties of vegetables and fruits available in local market of Shorkot Pakistan. Int J Curr Pharm Res 5:100–105
Cabrera C, Lloris F, Giménez R et al (2003) Mineral content in legumes and nuts: contribution to the Spanish dietary intake. Sci Total Environ 308:1–14. https://doi.org/10.1016/S0048-9697(02)00611-3
Campos J, Mourão J, Pestana N et al (2013) Microbiological quality of ready-to-eat salads: an underestimated vehicle of bacteria and clinically relevant antibiotic resistance genes. Int J Food Microbiol 166:464–470. https://doi.org/10.1016/j.ijfoodmicro.2013.08.005
Cang L (2004) Heavy metals pollution in poultry and livestock feeds and manures under intensive farming in Jiangsu Province, China. J Environ Sci 16:371–374
Cangul H, Broday L, Salnikow K et al (2002) Molecular mechanisms of nickel carcinogenesis. Toxicol Lett 127:69–75. https://doi.org/10.1016/S0378-4274(01)00485-4
Chandorkar S, Vaze N (2013) Analysis of metal content of organic foods. J Environ Sci Toxicol Food Technol 3:44–49
Chary SN, Kamala CTCT, Raj DSS et al (2008) Assessing risk of heavy metals from consuming food grown on sewage irrigated soils and food chain transfer. Ecotoxicol Environ Saf 69:513–524. https://doi.org/10.1016/j.ecoenv.2007.04.013
Chen Z, Setagawa M, Kang Y et al (2009) Zinc and cadmium uptake from a metalliferous soil by a mixed culture of Athyrium yokoscense and Arabis flagellosa. Soil Sci Plant Nutr 55:315–324. https://doi.org/10.1111/j.1747-0765.2008.00351.x
Chuan MC, Shu GY, Liu JC (1996) Solubility of heavy metals in a contaminated soil: effects of redox potential and pH. Water Air Soil Pollut 90:543–556
Cindric IJ, Zeiner M, Steffan I (2007) Trace elemental characterization of edible oils by ICP-AES and GFAAS. Microchem J 85:136–139. https://doi.org/10.1016/j.microc.2006.04.011
Costa M, Klein CB (1999) Nickel carcinogenesis, mutation, epigenetics, or selection. Environ Health Perspect 107:438–439. pii: sc271_5_1835
Courchesne F, Cloutier-Hurteau B, Turmel M-C (2008) Relevance of rhizosphere research to the ecological risk assessment of trace metals in soils. Hum Ecol Risk Assess 14:54–72
Crespo-López ME, Macêdo GL, Pereira SID et al (2009) Mercury and human genotoxicity: critical considerations and possible molecular mechanisms. Pharmacol Res 60:212–220. https://doi.org/10.1016/j.phrs.2009.02.011
Dakora FD, Phillips DA (2002) Root exudates as mediators of mineral acquisition in low-nutrient environments. Plant Soil 245:35–47. https://doi.org/10.1023/A:1020809400075
Das AK, Sahu R, Dua TK et al (2010) Arsenic-induced myocardial injury: protective role of Corchorus olitorius leaves. Food Chem Toxicol 48:1210–1217
Degryse F, Vlassak V, Smolders E, Merckx R (2007) Mobilization of Cd upon acidification of agricultural soils: column study and field modelling. Eur J Soil Sci 58:152–165. https://doi.org/10.1111/j.1365-2389.2006.00820.x
Demirezen D, Aksoy A (2006) Heavy metal levels in vegetables in Turkey are within safe limits for Cu, Zn, Ni and exceeded for Cd and Pb. J Food Qual 29:252–265
Denkhaus E, Salnikow K (2002) Nickel essentiality, toxicity, and carcinogenicity. Crit Rev Oncol Hematol 42:35–56. https://doi.org/10.1016/S1040-8428(01)00214-1
Derakhshan Z, Faramarzian M, Mahvi AH et al (2016) Assessment of heavy metals residue in edible vegetables distributed in Shiraz, Iran. J Food Qual Hazards Control 3:25–29
Dietrich MO, Mantese CE, dos Anjos G et al (2005) Motor impairment induced by oral exposure to methylmercury in adult mice. Environ Toxicol Pharmacol 19:169–175
Dike NI, Odunze AC (2016) Elemental contents of spinach and lettuce from irrigated gardens in Kano, Nigeria. Environ Pollut 5:73. https://doi.org/10.5539/ep.v5n1p73
Dike NI, Ezealor AU, Oniye SJ (2004) Concentration of Pb, Cu, Fe and Cd during the dry season in river Jakara, Kano, Nigeria. Chemclass J 1:78–81
Dogheim SM, Ashraf el MM, Alla SA et al (2004) Pesticides and heavy metals levels in Egyptian leafy vegetables and some aromatic medicinal plants. Food Addit Contam 21:323–330. https://doi.org/10.1080/02652030310001656361
Duran A, Tuzen M, Soylak M (2008) Trace element levels in some dried fruit samples from Turkey. Int J Food Sci Nutr 59:581–589. https://doi.org/10.1080/13561820701507910
Dykes L, Rooney L (2007) Phenolic compounds in cereal grains and their health benefits. Cereal Foods World 52:105–111. https://doi.org/10.1094/CFW-52-3-0105
EFSA (2017) Metals as contaminants in food. European Food Safety Authority, Parma. https://www.efsa.europa.eu/en/topics/topic/metals-contaminants-food. Accessed 10 Nov 2018
Ekholm P, Reinivuo H, Mattila P et al (2007) Changes in the mineral and trace element contents of cereals, fruits and vegetables in Finland. J Food Compos Anal 20:487–495. https://doi.org/10.1016/j.jfca.2007.02.007
Elbagermi MA, Edwards HGM, Alajtal AI (2012) Monitoring of heavy metal content in fruits and vegetables collected from production and market sites in the Misurata area of Libya. ISRN Anal Chem 2012:1–5. https://doi.org/10.5402/2012/827645
Elouear Z, Bouhamed F, Boujelben N, Bouzid J (2016) Application of sheep manure and potassium fertilizer to contaminated soil and its effect on zinc, cadmium and lead accumulation by alfalfa plants. Sustain Environ Res 26:131–135
Ercal N, Gurer-Orhan H, Aykin-Burns N (2001) Toxic metals and oxidative stress. Part I: mechanisms involved in metal induced oxidative damage. Curr Top Med Chem 1:529–539. https://doi.org/10.2174/1568026013394831
FAO (2013) Food supply database 2013. Food and Agricultural Organization, Rome. http://faostat3.fao.org/browse/FB/CL/E. Accessed 1 Jan 2017
Fardet A (2010) New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre? Nutr Res Rev 23:65–134. https://doi.org/10.1017/S0954422410000041
Farooq M, Anwar F, Rashid U (2008) Appraisal of heavy metal contents in different vegetables grown in the vicinity of an industrial area. Pak J Bot 40:2099–2106
Ferrario D, Croera C, Brustio R et al (2008) Toxicity of inorganic arsenic and its metabolites on haematopoietic progenitors “in vitro”: comparison between species and sexes. Toxicology 249:102–108. https://doi.org/10.1016/j.tox.2008.04.008
Flight I, Clifton P (2006) Cereal grains and legumes in the prevention of coronary heart disease and stroke: a review of the literature. Eur J Clin Nutr 60:1145–1159. https://doi.org/10.1038/sj.ejcn.1602435
Friberg L, Elinder CG (1993) Biological monitoring of toxic metals. Scand J Work Environ Health 19:7–13
Garrido S, Campo G, Esteller M et al (2005) Heavy metals in soil treated with sewage sludge composting, their effect on yield and uptake of broad bean seeds (Vicia faba L.). Water Air Soil Pollut 166:303–319
Geng A, Wang X, Wu L et al (2017) Arsenic accumulation and speciation in rice grown in arsanilic acid-elevated paddy soil. Ecotoxicol Environ Saf 137:172–178. https://doi.org/10.1016/j.ecoenv.2016.11.030
George G, Gqaza BM (2015) Arsenic contamination of selected indigenous and exotic leafy vegetables in the Eastern Cape province of South Africa. J Adv Agric Technol 2:29–33. https://doi.org/10.12720/joaat.2.1.29-33
Gilroy S, Jones DL (2000) Through form to function: root hair development and nutrient uptake. Trends Plant Sci 5:56–60. https://doi.org/10.1016/S1360-1385(99)01551-4
Guerra F, Trevizam AR, Muraoka T et al (2012) Heavy metals in vegetables and potential risk for human health. Sci Agric 69:54–60
Gupta S, Jyothi Lakshmi A, Manjunath MN, Prakash J (2005) Analysis of nutrient and antinutrient content of underutilized green leafy vegetables. LWT—Food Sci Technol 38:339–345. https://doi.org/10.1016/j.lwt.2004.06.012
Haiyan W, Stuanes AO (2003) Heavy metal pollution in air-water-soil-plant system of Zhuzhou City, Hunan Province, China. Water Air Soil Pollut 147:79–107
Hale B, Evans L, Lambert R (2012) Effects of cement or lime on Cd, Co, Cu, Ni, Pb, Sb and Zn mobility in field-contaminated and aged soils. J Hazard Mater 199–200:119–127. https://doi.org/10.1016/j.jhazmat.2011.10.065
Hamurcu M, Özcan MM, Dursun N, Gezgin S (2010) Mineral and heavy metal levels of some fruits grown at the roadsides. Food Chem Toxicol 48:1767–1770. https://doi.org/10.1016/j.fct.2010.03.031
Harcz P, De Temmerman L, De Voghel S et al (2007) Contaminants in organically and conventionally produced winter wheat (Triticum aestivum) in Belgium. Food Addit Contam 24:713–720. https://doi.org/10.1080/02652030601185071
Harmanescu M, Alda L, Bordean D et al (2011) Heavy metals health risk assessment for population via consumption of vegetables grown in old mining area; a case study: Banat County, Romania. Chem Cent J 5:64. https://doi.org/10.1186/1752-153X-5-64
Harraz FA, Abdel-Salam OE, Mostafa AA et al (2013) Rapid synthesis of titania-silica nanoparticles photocatalyst by a modified sol-gel method for cyanide degradation and heavy metals removal. J Alloys Compd 551:1–7. https://doi.org/10.1016/j.jallcom.2012.10.004
Hellström L, Elinder C-G, Dahlberg B et al (2001) Cadmium exposure and end-stage renal disease. Am J Kidney Dis 38:1001–1008
Hernández-Martínez R, Navarro-Blasco I (2013) Survey of total mercury and arsenic content in infant cereals marketed in Spain and estimated dietary intake. Food Control 30:423–432. https://doi.org/10.1016/j.foodcont.2012.08.016
Holmes DR (2002) Was your mother right: do we always need to close the door? Circulation 106:1034–1036. https://doi.org/10.1161/01.CIR.0000029818.65521.A9
Horswell J, Speir T (2006) Arsenic phytotoxicity: effect on crop yield and crop quality. In: Nadebaum P, Naidu R, Smith E et al (eds) Managing arsenic in the environment: from soil to human health. CSIRO Publishing, Clayton, pp 183–208
Horswell J, Weitz HJ, Percival HJ, Speir TW (2006) Impact of heavy metal amended sewage sludge on forest soils as assessed by bacterial and fungal biosensors. Biol Fertil Soils 42:569–576. https://doi.org/10.1007/s00374-005-0070-5
Hu X, Jin W, Lv W et al (2013) Investigation and evaluation on heavy metal copper and cadmium contaminations of vegetables grown in Huanggang city of China. Adv J Food Sci Technol 5:106–109
Hunaiti AA, Soud M (2000) Effect of lead concentration on the level of glutathione, glutathione S-transferase, reductase and peroxidase in human blood. Sci Total Environ 248:45–50. https://doi.org/10.1016/S0048-9697(99)00548-3
Hymete A, Eticha T (2015) Determination of some heavy metals in barley locally grown for brewing and it’s Malt in Ethiopia. J Bioanal Biomed 7:171–173. https://doi.org/10.4172/1948-593X.1000139
IARC (2017) IARC monographs on the evaluation of carcinogenic risks to humans. International Agency for Research on Cancer, Lyon. http://www.iarc.fr/. Accessed 30 Jan 2017
Ihesinachi K, Eresiya D (2014) Evaluation of heavy metals in orange, pineapple, avocado pear and pawpaw from a farm in Kaani, Bori, Rivers State. Int Res J Public Environ Heal 1:87–94
Iqbal A, Khalil IA, Ateeq N, Sayyar Khan M (2006) Nutritional quality of important food legumes. Food Chem 97:331–335. https://doi.org/10.1016/j.foodchem.2005.05.011
Islam MS, Ahmed MK, Habibullah-Al-Mamun M (2014) Heavy metals in cereals and pulses: health implications in Bangladesh. J Agric Food Chem 62:10828–10835. https://doi.org/10.1021/jf502486q
Ismael DS, Nabil RH, Dina AS (2016) The relationship of heavy metals contents in soils to their content in legume seeds used in famous traditional food in Kurdistan region-Iraq. Potravinarstvo 10:550–556. https://doi.org/10.5219/663
Ismail F, Anjum MR, Mamon AN, Kazi TG (2011) Trace metal contents of vegetables and fruits of Hyderabad retail market. Pakistan J Nutr 10:365–372. https://doi.org/10.3923/pjn.2011.365.372
Ismail A, Riaz M, Akhtar S et al (2014) Heavy metals in vegetables and respective soils irrigated by canal, municipal waste and tube well waters. Food Addit Contam B 7:213–219. https://doi.org/10.1080/19393210.2014.888783
Jaishankar M, Tseten T, Anbalagan N et al (2014) Toxicity, mechanism and health effects of some heavy metals. Interdiscip Toxicol 7:60–72. https://doi.org/10.2478/intox-2014-0009
Järup L (2003) Hazards of heavy metal contamination. Br Med Bull 68:167–182. https://doi.org/10.1093/bmb/ldg032
Jarup L, Akesso A (2009) Current status of cadmium as an environmental health problem. Toxicol Appl Pharmacol 238:201–208
Jin T, Nordberg G, Ye T et al (2004) Osteoporosis and renal dysfunction in a general population exposed to cadmium in China. Environ Res 96:353–359. https://doi.org/10.1016/j.envres.2004.02.012
Johnson C (2004) Mercury in the environment: sources, toxicities, and prevention of exposure. Pediatr Ann 33:437–442
Jomova K, Valko M (2011) Advances in metal-induced oxidative stress and human disease. Toxicology 283:65–87. https://doi.org/10.1016/j.tox.2011.03.001
Jorhem L, Sundström B, Engman J (2001) Cadmium and other metals in Swedish wheat and rye flours: longitudinal study, 1983–1997. J AOAC Int 84:1984–1992
Joshipura KJ, Hung HC, Rimm EB et al (2003) Periodontal disease, tooth loss, and incidence of ischemic stroke. Stroke 34:47–52. https://doi.org/10.1161/01.STR.0000052974.79428.0C
Kalis EJJ, Temminghoff EJM, Weng L, van Riemsdijk WH (2006) Effects of humic acid and competing cations on metal uptake by Lolium perenne. Environ Toxicol Chem 25:702–711
Karavoltsos S, Sakellari A, Dimopoulos M et al (2002) Cadmium content in foodstuffs from the Greek market. Food Addit Contam 19:954–962. https://doi.org/10.1080/02652030210136973
Khan MA, Castro-Guerrero N, Mendoza-Cozatl DG (2014) Moving toward a precise nutrition: preferential loading of seeds with essential nutrients over non-essential toxic elements. Front Plant Sci 5:51. https://doi.org/10.3389/fpls.2014.00051
Khan ZI, Ahmad K, Ashraf M et al (2015) Bioaccumulation of heavy metals and metalloids in luffa (Luffa cylindrica L.) irrigated with domestic wastewater in Jhang, Pakistan: a prospect for human nutrition. Pakistan J Bot 47:217–224
Kim B, McBride MB, Richards BK, Steenhuis TS (2007) The long-term effect of sludge application on Cu, Zn, and Mo behavior in soils and accumulation in soybean seeds. Plant Soil 299:227–236. https://doi.org/10.1007/s11104-007-9377-3
Krejpcio Z, Sionkowski S, Bartela J (2005) Safety of fresh fruits and juices available on the Polish market as determined by heavy metal residues. Polish J Environ Stud 14:877–881
Krohn RM, Raqib R, Akhtar E et al (2016) A high-selenium lentil dietary intervention in Bangladesh to counteract arsenic toxicity: study protocol for a randomized controlled trial. Trials 17:218. https://doi.org/10.1186/s13063-016-1344-y
Lambert R, Grant C, Sauvé S (2007) Cadmium and zinc in soil solution extracts following the application of phosphate fertilizers. Sci Total Environ 378:293–305. https://doi.org/10.1016/j.scitotenv.2007.02.008
Leblanc J, Guérin T, Noël L et al (2005) Dietary exposure estimates of 18 elements from the 1st French Total Diet Study. Food Addit Contam 22:624–641. https://doi.org/10.1080/02652030500135367
Lente I, Brimah AK, Atiemo S et al (2014) Heavy metal pollution of vegetable crops irrigated with wastewater in Accra, Ghana. West African J Appl Ecol 22:41–58
Leshe S, Tessema M (2014) Determination of levels of essential and toxic heavy metals in lentil (Lens Culinaris Medik) by flame atomic. AJCE 4:16–34
Lin J-Y, Tang C-Y (2007) Determination of total phenolic and flavonoid contents in selected fruits and vegetables, as well as their stimulatory effects on mouse splenocyte proliferation. Food Chem 101:140–147. https://doi.org/10.1016/j.foodchem.2006.01.014
Linkon KMMR, Satter MA, Jabin SA et al (2015) Mineral and heavy metal contents of some vegetable available in local market of Dhaka city in Bangladesh. IOSR J Environ Sci Toxicol Food Technol 9:2319–2399. https://doi.org/10.9790/2402-09510106
Liu X, Song Q, Tang Y et al (2013) Human health risk assessment of heavy metals in soil–vegetable system: a multi-medium analysis. Sci Total Environ 463–464:530–540. https://doi.org/10.1016/j.scitotenv.2013.06.064
Llorent-Martínez EJ, Ortega-Barrales P, Fernández-De Córdova ML et al (2011) Investigation by ICP-MS of trace element levels in vegetable edible oils produced in Spain. Food Chem 127:1257–1262. https://doi.org/10.1016/j.foodchem.2011.01.064
Manchali S, Chidambara Murthy KN, Patil BS (2012) Crucial facts about health benefits of popular cruciferous vegetables. J Funct Foods 4:94–106. https://doi.org/10.1016/j.jff.2011.08.004
Maqsood M, Hussain S, Aziz T, Ashraf M (2011) Wheat-exuded organic acids influence zinc release from calcareous soils. Pedosphere 21:657–665
Martorell I, Perelló G, Martí-Cid R et al (2011) Human exposure to arsenic, cadmium, mercury, and lead from foods in Catalonia, Spain: temporal trend. Biol Trace Elem Res 142:309–322. https://doi.org/10.1007/s12011-010-8787-x
Mausi G, Simiyu G, Lutta S (2014) Assessment of selected heavy metal concentrations in selected fresh fruits in Eldoret Town, Kenya. J Environ Earth Sci 4:1–8
McLaughlin MJ, Hamon RE, McLaren RG et al (2000) Review: a bioavailability-based rationale for controlling metal and metalloid contamination of agricultural land in Australia and New Zealand. Soil Res 38:1037–1086
MedlinePlus (2014) Vegeterian diet. U.S. National Library of Medicine, Bethesda, MD. https://medlineplus.gov/ency/article/002465.htm. Accessed 30 Jan 2017
Mehari TF, Greene L, Duncan AL, Fakayode SO (2015) Trace and macro elements concentrations in selected fresh fruits, vegetables, herbs, and processed foods in North Carolina, USA. J Environ Prot (Irvine, CA) 6:573–583
Menke A, Muntner P, Silbergeld EK et al (2009) Cadmium levels in urine and mortality among U.S. adults. Environ Health Perspect 117:190–196. https://doi.org/10.1289/ehp.11236
Mertz W (ed) (1986) Trace elements in human and animal nutrition, 5th edn. Academic Press, Inc., Orlando, FL
Messner B, Bernhard D (2010) Cadmium and cardiovascular diseases: cell biology, pathophysiology, and epidemiological relevance. BioMetals 23:811–822
Micić RJ, Dimitrijević DS, Kostić DA et al (2013) Content of heavy metals in mulberry fruits and their extracts-correlation analysis. Am J Anal Chem 4:674–682. https://doi.org/10.4236/ajac.2013.411081
Mohammadpourfard I, Shariatifar N, Jahed-Khaniki GR, Ebadi-Fathabad E (2015) Determination of heavy metals in apricot and almond oils. Iran J Heal Sci 3:18–24. https://doi.org/10.3760/cma.j.issn.0366-6999.2010.07.014
Moodley R, Kindness A, Jonnalagadda SB (2007) Elemental composition and chemical characteristics of five edible nuts (almond, Brazil, pecan, macadamia and walnut) consumed in Southern Africa. J Environ Sci Health B 42:585–591. https://doi.org/10.1080/03601230701391591
Moon K, Guallar E, Navas-Acien A (2012) Arsenic exposure and cardiovascular disease: an updated systematic review. Curr Atheroscler Rep 14:542–555
Mubofu EB (2012) Heavy metal content in some commonly consumed vegetables from Kariakoo market, Dar es Salaam, Tanzania. Tanz J Sci 38:201–208
Mudryj AN, Yu N, Aukema HM (2014) Nutritional and health benefits of pulses. Appl Physiol Nutr Metab 39:1197–1204. https://doi.org/10.1139/apnm-2013-0557
Mulligan CN, Yong RN, Gibbs BF (2001) Remediation technologies for metal-contaminated soils and groundwater: an evaluation. Eng Geol 60:193–207. https://doi.org/10.1016/S0013-7952(00)00101-0
Muñoz O, Bastias JM, Araya M et al (2005) Estimation of the dietary intake of cadmium, lead, mercury, and arsenic by the population of Santiago (Chile) using a Total Diet Study. Food Chem Toxicol 43:1647–1655. https://doi.org/10.1016/j.fct.2005.05.006
Mustapha H, Adeboye O (2014) Heavy metals accumulation in edible part of vegetables irrigated with untreated municipal wastewater in tropical savannah zone, Nigeria. African J Environ Sci Technol 8:460–463. https://doi.org/10.5897/AJEST2013.1531
Nankishore A (2014) Heavy metal levels in leafy vegetables from selected markets in Guyana. J Agric Technol 10:651–663
Naujokas MF, Anderson B, Ahsan H et al (2013) The broad scope of health effects from chronic arsenic exposure: update on a worldwide public health problem. Environ Health Perspect 121:295–302. https://doi.org/10.1289/ehp.1205875
Ng JC, Wang J, Shraim A (2003) A global health problem caused by arsenic from natural sources. Chemosphere 52:1353–1359. https://doi.org/10.1016/S0045-6535(03)00470-3
Nielsen FH, Myron DR, Givand SH et al (1975) Nickel deficiency in rats. J Nutr 105:1620–1630
Nielsen FH, Shuler TR, McLeod TG, Zimmerman TJ (1984) Nickel influences iron metabolism through physiologic, pharmacologic and toxicologic mechanisms in the rat. J Nutr 114:1280–1288
Nielsen GD, Søderberg U, Jørgensen PJ et al (1999) Absorption and retention of nickel from drinking water in relation to food intake and nickel sensitivity. Toxicol Appl Pharmacol 154:67–75. https://doi.org/10.1006/taap.1998.8577
Nogaim QA, Makarem M, Alwah M, Atef M (2013) Survey of some heavy metals in Yemeni vegetables. Merit Res J Food Sci Technol 1:36–42
Nogawa K, Kobayashi E, Okubo Y, Suwazono Y (2004) Environmental cadmium exposure, adverse effects and preventive measures in Japan. In: BioMetals. Springer, Basel, pp 581–587
Nordberg G, Jin T, Bernard A et al (2002) Low bone density and renal dysfunction following environmental cadmium exposure in China. AMBIO: J Human Environ 31:478–481. http://dx.doi.org/10.1639/0044-7447(2002)031[0478:LBDARD]2.0.CO;2
NTP (2011) NTP 12th report on carcinogens. U.S. Department of Health and Human Services, Washington, DC
Ogunkunle ATJ, Bello OS, Ojofeitimi OS (2014) Determination of heavy metal contamination of street-vended fruits and vegetables in Lagos state, Nigeria. Int Food Res J 21:2115–2120
Ohta H, Cherian MG (1991) Gastrointestinal absorption of cadmium and metallothionein. Toxicol Appl Pharmacol 107:63–72. https://doi.org/10.1016/0041-008X(91)90331-8
Okarter N, Liu RH (2010) Health benefits of whole grain phytochemicals. Food Eng Ingredients 35:18–22. https://doi.org/10.1080/10408390802248734
Okoronkwo N, Igwe J, Onwuchekwa E (2005) Risk and health implications of polluted soils for crop production. African J Biotechnol 4:1521–1524
Olivieri G, Novakovic M, Savaskan E et al (2002) The effects of beta-estradiol on SHSY5Y neuroblastoma cells during heavy metal induced oxidative stress, neurotoxicity, and beta-amyloid secretion. Neuroscience 113:849–855. pii: S0306452202002117
Ondrasek G, Romic D, Rengel Z et al (2009) Cadmium accumulation by muskmelon under salt stress in contaminated organic soil. Sci Total Environ 407:2175–2182
Oorts K, Smolders E, Degryse F et al (2008) Solubility and toxicity of antimony trioxide (Sb2O3) in soil. Environ Sci Technol 42:4378–4383
Orisakwe OEOE, Nduka JKJK, Amadi CNCN et al (2012) Heavy metals health risk assessment for population via consumption of food crops and fruits in Owerri, South Eastern, Nigeria. Chem Cent J 6:1–7. https://doi.org/10.1186/1752-153X-6-77
Othman OC (2001) Heavy metals in green vegetables and soils from vegetable gardens in Dar es Salaam, Tanzania. Tanzania J Sci 27:37–48
Othman ZAA (2010) Lead contamination in selected foods from Riyadh city market and estimation of the daily intake. Molecules 15:7482–7497. https://doi.org/10.3390/molecules15107482
Payler D, Pomare E, Heaton K (1975) The effect of wheat bran on intestinal transit. Gut 16:209–213
Pehluvan M, Karlidag H, Turan M (2012) Heavy metal levels of mulberry (Morus alba L.) grown at different distances from the roadsides. J Anim Plant Sci 22:665–670
Peralta JR, Gardea-Torresdey JL, Tiemann KJ et al (2001) Uptake and effects of five heavy metals on seed germination and plant growth in alfalfa (Medicago sativa L.). Bull Environ Contam Toxicol 66:727–734. https://doi.org/10.1007/s001280069
Peralta-Videa JR, Lopez ML, Narayan M et al (2009) The biochemistry of environmental heavy metal uptake by plants: implications for the food chain. Int J Biochem Cell Biol 41:1665–1677. https://doi.org/10.1016/j.biocel.2009.03.005
Pereira MC, Boschetti W, Rampazzo R et al (2014) Mineral characterization of native fruits from the southern region of Brazil. Food Sci Technol 34:258–266. https://doi.org/10.1590/fst.2014.0049
Peters JL, Perlstein TS, Perry MJ et al (2010) Cadmium exposure in association with history of stroke and heart failure. Environ Res 110:199–206. https://doi.org/10.1016/j.envres.2009.12.004
Phuong TD, Chuong PV, Khiem DT, Kokot S (1999) Elemental content of Vietnamese rice. Part 1. Sampling, analysis and comparison with previous studies. Analyst 124:553–560. https://doi.org/10.1039/a808796b
Poiroux-Gonord F, Bidel LPR, Fanciullino AL et al (2010) Health benefits of vitamins and secondary metabolites of fruits and vegetables and prospects to increase their concentrations by agronomic approaches. J Agric Food Chem 58:12065–12082. https://doi.org/10.1021/jf1037745
Radwan MA, Salama AK (2006) Market basket survey for some heavy metals in Egyptian fruits and vegetables. Food Chem Toxicol 44:1273–1278. https://doi.org/10.1016/j.fct.2006.02.004
Rahman IMM, Hasan MT (2007) Arsenic incorporation into garden vegetables irrigated with contaminated water. J Appl Sci Environ Manag 11:105–112
Rahman MA, Rahman MM, Reichman SM et al (2014) Heavy metals in Australian grown and imported rice and vegetables on sale in Australia: health hazard. Ecotoxicol Environ Saf 100:53–60. https://doi.org/10.1016/j.ecoenv.2013.11.024
Ramesh HL, Murthy VNY (2010) Assessment of heavy metal contamination in green leafy vegetables grown in Bangalore urban district of Karnataka. Adv Life Sci Technol 6:40–51
Rao MV, Chinoy NJ, Suthar MB, Rajvanshi MI (2001) Role of ascorbic acid on mercuric chloride-induced genotoxicity in human blood cultures. Toxicol In Vitro 15:649–654
Rashed MN (2015) Photocatalytic degradation of divalent metals under sunlight irradiation using nanoparticle TiO2 modified concrete materials (recycled glass cullet). In: Recent progress in desalination, environmental and marine outfall systems. Springer International Publishing, Cham, pp 93–108
Raskin I, Ribnicky DM, Komarnytsky S et al (2002) Plants and human health in the twenty-first century. Trends Biotechnol 20:522–531. https://doi.org/10.1016/S0167-7799(02)02080-2
Ravi V, Gangadhar B, Naidu GR, Basha ST (2012) Toxicity of heavy metals in Totapuri mango in Chittoor district of Andhra Pradesh. ASIAN J Environ Sci 7:62–66
Rehman W, Shah SWH, Younis K et al (2011) A comparative study of various grains from the different cities of Pakistan. Environ Monit Assess 175:151–156. https://doi.org/10.1007/s10661-010-1501-9
Rodushkin I, Engström E, Sörlin D, Baxter D (2008) Levels of inorganic constituents in raw nuts and seeds on the Swedish market. Sci Total Environ 392:290–304. https://doi.org/10.1016/j.scitotenv.2007.11.024
Rose M, Baxter M, Brereton N, Baskaran C (2010) Dietary exposure to metals and other elements in the 2006 UK Total Diet Study and some trends over the last 30 years. Food Addit Contam 27:1380–1404. https://doi.org/10.1080/19440049.2010.496794
Roy A, Manna P, Sil PC (2009) Prophylactic role of taurine on arsenic mediated oxidative renal dysfunction via MAPKs/NF-kappaB and mitochondria dependent pathways. Free Radic Res 43:995–1007. https://doi.org/10.1080/10715760903164998
Sabaté J, Ang Y (2009) Nuts and health outcomes: new epidemiologic evidence. Am J Clin Nutr 89:1643S–1648S. https://doi.org/10.3945/ajcn.2009.26736Q.Am
Sacks FM, Appel LJ, Moore TJ et al (1999) A dietary approach to prevent hypertension: a review of the Dietary Approaches to Stop Hypertension (DASH) Study. Clin Cardiol 22:III6–II10. https://doi.org/10.1002/clc.4960221503
Saeed A, Akhter MW, Iqbal M (2005) Removal and recovery of heavy metals from aqueous solution using papaya wood as a new biosorbent. Sep Purif Technol 45:25–31. https://doi.org/10.1016/j.seppur.2005.02.004
Saha N, Zaman MR (2013) Evaluation of possible health risks of heavy metals by consumption of foodstuffs available in the central market of Rajshahi City, Bangladesh. Environ Monit Assess 185:3867–3878. https://doi.org/10.1007/s10661-012-2835-2
Saini M, Sharma KC, Sharma M (2014) Study of heavy metal accumulation in Spinach irrigated with industrial waste water of Bhiwadi industrial area, Rajasthan. Res J Biol 2:66–72
Sajib MAM, Jahan S, Islam MZ et al (2014) Nutritional evaluation and heavy metals content of selected tropical fruits in Bangladesh. Int Food Res J 21:609–615
Sakamoto M, Kakita A, Wakabayashi K et al (2002) Evaluation of changes in methylmercury accumulation in the developing rat brain and its effects: a study with consecutive and moderate dose exposure throughout gestation and lactation periods. Brain Res 949:51–59
Salnikow K, Zhitkovich A (2007) Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium. Chem Res Toxicol 21:28–44
Samal L, Garg AK (2012) Status of toxic heavy metals in cereal grains and pulses in Bareilly district of Uttar Pradesh. Indian Vet J 89:25–27
Samikkannu T, Chen C-H, Yih L-H et al (2003) Reactive oxygen species are involved in arsenic trioxide inhibition of pyruvate dehydrogenase activity. Arch Environ Health Int J 16:409–414
Santos E, Lauria D, Porto da Silveira C (2004) Assessment of daily intake of trace elements due to consumption of foodstuffs by adult inhabitants of Rio de Janeiro city. Sci Total Environ 327:69–79. https://doi.org/10.1016/j.scitotenv.2004.01.016
Sarwar F (2013) The role of oilseeds nutrition in human health: a critical review. J Cereal Oilseeds 4:97–100. https://doi.org/10.5897/JCO12.024
Satarug S, Baker JR, Reilly PEB et al (2002) Cadmium levels in the lung, liver, kidney cortex, and urine samples from Australians without occupational exposure to metals. Arch Environ Health 57:69–77. https://doi.org/10.1080/00039890209602919
Sattar A, Wahid M, Durrani SK (1989) Concentration of selected heavy metals in spices, dry fruits and plant nuts. Plant Foods Hum Nutr 39:279–286. https://doi.org/10.1007/BF01091938
Schmidt A, Anke M, Groppel B, Kronemann H (1984) Effects of As-deficiency on skeletal muscle, myocardium and liver—a histochemical and ultrastructural study. Exp Pathol 25:195–197
Sharma RK, Agrawal M, Marshall FM (2007) Heavy metals contamination of soil and vegetables in suburban areas of Varanasi. Ecotoxicol Environ Saf 66:37–41
Sharma RK, Agrawal M, Marshall FM (2009) Heavy metals in vegetables collected from production and market sites of a tropical urban area of India. Food Chem Toxicol 47:583–591. https://doi.org/10.1016/j.fct.2008.12.016
Sigel A, Sigel H, Sigel R (eds) (2013) Interrelations between essential metal ions and human diseases. Springer, Dordrecht
Silbergeld EK, Waalkes M (2000) Lead as a carcinogen: experimental evidence and mechanisms of action. Am J Ind Med 38:316–323. https://doi.org/10.1002/1097-0274
Singh V, Garg AN (2006) Availability of essential trace elements in Indian cereals, vegetables and spices using INAA and the contribution of spices to daily dietary intake. Food Chem 94:81–89. https://doi.org/10.1016/j.foodchem.2004.10.053
Singh A, Sharma RK, Agrawal M, Marshall FM (2010) Health risk assessment of heavy metals via dietary intake of foodstuffs from the wastewater irrigated site of a dry tropical area of India. Food Chem Toxicol 48:611–619
Sobukola OP, Adeniran OM, Odedairo AA, Kajihausa OE (2010) Heavy metal levels of some fruits and leafy vegetables from selected markets in Lagos, Nigeria. African J Food Sci 4:389–393
Sood A, Uniyal PL, Prasanna R, Ahluwalia AS (2012) Phytoremediation potential of aquatic macrophyte, Azolla. Ambio 41:122–137
Spears JW, Harvey RW, Samsell LJ (1986) Effects of dietary nickel and protein on growth, nitrogen metabolism and tissue concentrations of nickel, iron, zinc, manganese and copper in calves. J Nutr 116:1873–1882
Staessen JA, Roels HA, Emelianov D et al (1999) Environmental exposure to cadmium, forearm bone density, and risk of fractures: prospective population study. Lancet 353:1140–1144
Stančić Z, Vujević D, Gomaz A et al (2016) Detection of heavy metals in common vegetables at Varaždin City Market, Croatia. Arch Ind Hyg Toxicol 67:340–350. https://doi.org/10.1515/aiht-2016-67-2823
Stangl GI, Kirchgessner M (1996) Nickel deficiency alters liver lipid metabolism in rats. J Nutr 126:2466
Stark AH, Madar Z (2002) Olive oil as a functional food: epidemiology and nutritional approaches. Nutr Rev 60:170–176
Steenland K, Boffetta P (2000) Lead and cancer in humans: where are we now? Am J Ind Med 38:295–299. https://doi.org/10.1002/1097-0274(200009)38:3<295::AID-AJIM8>3.0.CO;2-L
Škrbić B, Živančev J, Mrmoš N (2013) Concentrations of arsenic, cadmium and lead in selected foodstuffs from Serbian market basket: estimated intake by the population from the Serbia. Food Chem Toxicol 58:440–448. https://doi.org/10.1016/j.fct.2013.05.026
Tangahu BV, Sheikh Abdullah SR, Basri H et al (2011) A review on heavy metals (As, Pb, and Hg) uptake by plants through phytoremediation. Int J Chem Eng 2011:1–31. https://doi.org/10.1155/2011/939161
Tasrina R, Rowshon A (2015) Heavy metals contamination in vegetables and its growing soil. J Environ Anal Chem 2:142. https://doi.org/10.4172/2380-2391.1000142
Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ (2012) Heavy metals toxicity and the environment. Mol Clin Environ Toxicol 101:133–164. https://doi.org/10.1007/978-3-7643-8340-4_6
Tegegne WA (2015) Assessment of some heavy metals concentration in selected cereals collected from local markets of Ambo City, Ethiopia. J Cereal Oilseeds 6:8–13. https://doi.org/10.5897/JCO15.0138
Tejera RL, Luis G, González-Weller D et al (2013) Metals in wheat flour; comparative study and safety control. Nutr Hosp 28:506–513. https://doi.org/10.3305/nh.2013.28.2.6287
Tipping E, Smith EJ, Lawlor AJ et al (2003) Predicting the release of metals from ombrotrophic peat due to drought-induced acidification. Environ Pollut 123:239–253
Tremaroli V, Bäckhed F (2012) Functional interactions between the gut microbiota and host metabolism. Nature 489:242–249. https://doi.org/10.1038/nature11552
Tripathi RM, Raghunath R, Krishnamoorthy TM (1997) Dietary intake of heavy metals in Bombay city, India. Sci Total Environ 208:149–159. https://doi.org/10.1016/S0048-9697(97)00290-8
ul Islam E, Yang X, He Z, Mahmood Q (2007) Assessing potential dietary toxicity of heavy metals in selected vegetables and food crops. J Zhejiang Univ Sci B 8:1–13
USDA (2018) USDA food composition databases: National Nutrient Database for Standard Reference. United States Department of Agriculture Agricultural Research Service, Washington, DC. https://ndb.nal.usda.gov/ndb/foods. Accessed 10 Nov 2018
Usubalieva А, Batkibekova M, Hintelmann H, Judge R (2013) The content of zinc, copper, lead and cadmium in some vegetables of Kyrgyzstan. Pakistan J Food Sci 23:189–193
Uthus EO (1992) Evidence for arsenic essentiality. Environ Geochem Health 14:55–58. https://doi.org/10.1007/BF01783629
Uthus EO (2003) Arsenic essentiality: a role affecting methionine metabolism. J Trace Elem Exp Med 16:345–355. https://doi.org/10.1002/jtra.10044
von Hoffen LP, Säumel I (2014) Orchards for edible cities: cadmium and lead content in nuts, berries, pome and stone fruits harvested within the inner city neighbourhoods in Berlin, Germany. Ecotoxicol Environ Saf 101:233–239. https://doi.org/10.1016/j.ecoenv.2013.11.023
Valko M, Leibfritz D, Moncol J et al (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39:44–84
Verstraeten SV, Aimo L, Oteiza PI (2008) Aluminium and lead: molecular mechanisms of brain toxicity. Arch Toxicol 82:789–802
Viehweger K (2014) How plants cope with heavy metals. Bot Stud 55:35. https://doi.org/10.1186/1999-3110-55-35
Vollmannova A, Zupka S, Bajcan D, et al (2015) Dangerous heavy metals in soil and small forest fruit as a result of old environmental loads. In: Proceedings of the 14th international conference on environmental science and technology, pp 3–5
Waalkes MP, Diwan BA, Ward JM et al (1995) Renal tubular tumors and atypical hyperplasias in B6C3F1 mice exposed to lead acetate during gestation and lactation occur with minimal chronic nephropathy. Cancer Res 55:5265–5271
Waalkes MP, Liu J, Ward JM, Diwan BA (2004) Animal models for arsenic carcinogenesis: inorganic arsenic is a transplacental carcinogen in mice. Toxicol Appl Pharmacol 198:377–384
Waisberg M, Joseph P, Hale B, Beyersmann D (2003) Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology 192:95–117
Wang HS, Sthiannopkao S, Chen ZJ et al (2013) Arsenic concentration in rice, fish, meat and vegetables in Cambodia: a preliminary risk assessment. Environ Geochem Health 35:745–755. https://doi.org/10.1007/s10653-013-9532-0
WCRF/AICR (2007) Food, nutrition, physical activity, and the prevention of cancer: a global perspective. World Cancer Research Fund/American Institute for Cancer Research, Washington, DC
WHO (2016) Mercury and health. http://www.who.int/mediacentre/factsheets/fs361/en/. Accessed 30 Jan 2017
WHO/FAO (2016) General standard for contaminants and toxins in food and feed. Food and Agriculture Organization, World Health Organization, Rome, Geneva
Wilcox DE (2013) Arsenic. Can this toxic metalloid sustain life? In: Sigel A, Sigel H, Sigel RKO (eds) Interrelations between essential, Metal ions and human diseases, metal ions in life sciences, vol 13. Springer, Dordrecht, pp 475–498
Williams J (2002) Phytoremediation in wetland ecosystems: progress, problems, and potential. CRC Crit Rev Plant Sci 21:607–635. https://doi.org/10.1080/0735-260291044386
Woods VB, Fearon AM (2009) Dietary sources of unsaturated fatty acids for animals and their transfer into meat, milk and eggs: a review. Livest Sci 126:1–20
Yadav A, Yadav PK, Shukla PDN (2013) Investigation of heavy metal status in soil and vegetables grown in urban area of Allahabad, Uttar Pradesh, India. Int J Sci Res Publ 3:1–7
Yahaya M (2013) Heavy metal levels in selected green leafy vegetables obtained from Katsina central market, Katsina, North-western Nigeria. African J Pure Appl Chem 7:179–183. https://doi.org/10.5897/AJPAC2013.0499
Yedjou CG, Tchounwou PB (2007) N-acetyl-L-cysteine affords protection against lead-induced cytotoxicity and oxidative stress in human liver carcinoma (HepG2) cells. Int J Environ Res Public Health 4:132–137
Yokoi K, Uthus EO, Nielsen FH (2003) Nickel deficiency diminishes sperm quantity and movement in rats. Biol Trace Elem Res 93:141–154. https://doi.org/10.1385/BTER:93:1-3:141
Youdim KA, McDonald J, Kalt W, Joseph JA (2002) Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults. J Nutr Biochem 13:282–288. https://doi.org/10.1016/S0955-2863(01)00221-2
Zahir F, Rizwi SJ, Haq SK, Khan RH (2005) Low dose mercury toxicity and human health. Environ Toxicol Pharmacol 20:351–360. https://doi.org/10.1016/j.etap.2005.03.007
Zahoor A, Jaffar M, Saqib M (2003) Elemental distribution in summer fruits of Pakistan. Nutr Food Sci 33:203–207. https://doi.org/10.1108/00346650310499712
Zhang Z, Solaiman ZM, Meney K et al (2013) Biochars immobilize soil cadmium, but do not improve growth of emergent wetland species Juncus subsecundus in cadmium-contaminated soil. J Soils Sediments 13:140–151. https://doi.org/10.1007/s11368-012-0571-4
Zheng N, Wang Q, Zhang X et al (2007) Population health risk due to dietary intake of heavy metals in the industrial area of Huludao city, China. Sci Total Environ 387:96–104. https://doi.org/10.1016/j.scitotenv.2007.07.044
Zhou Z, Fan Y, Wang M (2000) Heavy metal contamination in vegetables and their control in China. Food Rev Int 16(2):239–255. https://doi.org/10.1081/FRI-100100288
Zhu F, Fan W, Wang X et al (2011) Health risk assessment of eight heavy metals in nine varieties of edible vegetable oils consumed in China. Food Chem Toxicol 49:3081–3085. https://doi.org/10.1016/j.fct.2011.09.019
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Hussain, S., Rengel, Z., Qaswar, M., Amir, M., Zafar-ul-Hye, M. (2019). Arsenic and Heavy Metal (Cadmium, Lead, Mercury and Nickel) Contamination in Plant-Based Foods. In: Ozturk, M., Hakeem, K. (eds) Plant and Human Health, Volume 2. Springer, Cham. https://doi.org/10.1007/978-3-030-03344-6_20
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