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Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with social-communication deficits and restricted and/or repetitive behaviors and/or interests. The diagnostic criteria of the disorder have evolved over the years with new research on the features, associated symptoms, prevalence, and etiology of the disorder. This chapter offers an overview of the presentation, development, history, prevalence, and impact of ASD on the child and family. Research on the etiology of ASD, including potential risk factors and dispelled myths, is summarized.

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References

  • Ahearn, W. H., Castine, T., Nault, K., & Green, G. (2001). An assessment of food acceptance in children with autism or pervasive developmental disorder-not otherwise specified. Journal of Autism and Developmental Disorders, 31(5), 505–511.

    Article  PubMed  Google Scholar 

  • Allen, J., DeMyer, M. K., Norton, J. A., Pontius, W., & Yang, E. (1971). Intellectuality in parents of psychotic, subnormal, and normal children. Journal of Autism and Developmental Disorders, 1(3), 311–326.

    Article  Google Scholar 

  • American Psychiatric Association. (1968). Diagnostic and statistical manual of mental disorders: DSM-III. Washington, DC: American Psychiatric Association.

    Google Scholar 

  • American Psychiatric Association. (1987). Diagnostic and statistical manual of mental disorders: DSM-III-R. Washington, DC: American Psychiatric Association.

    Google Scholar 

  • American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders: DSM-IV. Washington, DC: American Psychiatric Association.

    Google Scholar 

  • American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders: DSM-IV-TR. Washington, DC: American Psychiatric Association.

    Google Scholar 

  • American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders: DSM-5. Washington, DC: American Psychiatric Association.

    Book  Google Scholar 

  • Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., & Rutter, M. (1995). Autism as a strongly genetic disorder: Evidence from a British twin study. Psychological Medicine, 25(1), 63–77.

    Article  PubMed  Google Scholar 

  • Baron-Cohen, S., Leslie, A. M., & Frith, U. (1985). Does the autistic child have a “theory of mind”? Cognition, 21(1), 37–46.

    Article  PubMed  Google Scholar 

  • Bauminger, N. (2002). The facilitation of social-emotional understanding and social interaction in high-functioning children with autism: Intervention outcomes. Journal of Autism and Developmental Disorders, 32(4), 283–298.

    Article  PubMed  Google Scholar 

  • Bauminger, N., Shulman, C., & Agam, G. (2003). Peer interaction and loneliness in high-functioning children with autism. Journal of Autism and Developmental Disorders, 33(5), 489–507.

    Article  PubMed  Google Scholar 

  • Bebko, J. M., Konstantareas, M. M., & Springer, J. (1987). Parent and professional evaluations of family stress associated with characteristics of autism. Journal of Autism and Developmental Disorders, 17(4), 565–576.

    Article  PubMed  Google Scholar 

  • Betancur, C. (2011). Etiological heterogeneity in autism spectrum disorders: More than 100 genetic and genomic disorders and still counting. Brain Research, 1380, 42–77.

    Article  PubMed  Google Scholar 

  • Brobst, J. B., Clopton, J. R., & Hendrick, S. S. (2008). Parenting children with autism spectrum disorders. Focus of Autism and Other Developmental Disabilities, 24(1), 38–49.

    Article  Google Scholar 

  • Bromley, J., Hare, D. J., Davison, K., & Emerson, E. (2004). Mothers supporting children with autistic spectrum disorders: Social support, mental health status and satisfaction with services. Autism, 8(4), 409–423.

    Article  PubMed  Google Scholar 

  • Bromley, R. L., Mawer, G. E., Briggs, M., Cheyne, C., Clayton-Smith, J., Garcia-Finana, M., … Baker, G. A. (2013). Journal of Neurology. Neurosurgery, and Psychiatry, 84(6), 637–643.

    Article  Google Scholar 

  • Brunetti-Pierri, N., Berg, J. S., Scagilla, F., Belmont, J., Bacino, C. A., Sahoo, T., … Patel, A. (2008). Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities. Nature Genetics, 40(12), 1466–14471.

    Article  PubMed  PubMed Central  Google Scholar 

  • Caron, M. J., Mottron, L., Rainville, C., & Chouinard, S. (2004). Do high functioning persons with autism present superior spatial abilities? Neuropsychologia, 42(4), 467–481.

    Article  PubMed  Google Scholar 

  • Centers for Disease Control and Prevention (CDC). (2015). Autism spectrum disorder (ASD): Data & statistics. Atlanta, GA: Centers for Disease Control and Prevention.

    Google Scholar 

  • Centers for Disease Control and Prevention (CDC). (2018). Prevalence of autism spectrum disorder among children aged 8 years – autism and developmental disabilities monitoring network, 11 sites, United States, 2014. Morbidity and Mortality Weekly Report Surveillance Summaries, 67(6), 1–23.

    Google Scholar 

  • Charman, T. (2003). Why is joint attention a pivotal skill in autism? The Royal Society, 358(1430), 315–324.

    Google Scholar 

  • Charman, T., Drew, A., Baird, C., & Baird, G. (2003). Measuring early language development in preschool children with autism spectrum disorder using the MacArthur Communicative Development Inventory (infant form). Journal of Child Language, 30(1), 213–236.

    Article  PubMed  Google Scholar 

  • Cidav, Z., Marcus, S. C., & Mandell, D. S. (2012). Implications of childhood autism for parental employment and earnings. Pediatrics, 129(4), 617–623.

    Article  PubMed  PubMed Central  Google Scholar 

  • Constantino, J. N., & Todd, R. D. (2003). Autistic traits in the general population: a twin study. Archives of General Psychiatry, 60(5), 524–530.

    Article  PubMed  Google Scholar 

  • Constantino, J. N., Zhang, Y., Frazier, T., Abbacchi, A. M., & Law, P. (2010). Sibling recurrence and the genetic epidemiology of autism. American Journal of Psychiatry, 167(11), 1349–1356.

    Article  PubMed  Google Scholar 

  • Cruz, L. P., Camargos-Júnior, W., & Rocha, F. L. (2013). The broad autism phenotype in parents of individuals with autism: A systematic review of the literature. Trends in Psychiatry and Psychotherapy, 35(4), 252–263.

    Article  PubMed  Google Scholar 

  • Dawson, G. (2008). Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder. Development and Psychopathology, 20(3), 775–803.

    Article  PubMed  Google Scholar 

  • DeMyer, M. K., Hingtgen, J. N., & Jackson, R. K. (1981). Infantile autism reviewed: A decade of research. Schizophrenia Bulletin, 7(3), 388–451.

    Article  PubMed  Google Scholar 

  • Diehl, J. J., & Paul, R. (2013). Acoustic and perceptual measurements of prosody production on the profiling elements of prosodic systems in children by children with autism spectrum disorders. Applied PsychoLinguistics, 34(1), 135–161.

    Article  Google Scholar 

  • Duarte, C. S., Bordin, I. A., Yazigi, L., & Mooney, J. (2005). Factors associated with stress in mothers of children with autism. Autism, 9(4), 416–427.

    Article  PubMed  Google Scholar 

  • Eigsti, I. M., de Marchena, A. B., Schuh, J. M., & Kelley, E. (2011). Language acquisition in autism spectrum disorders: A developmental review. Research in Autism Spectrum Disorders, 5(2), 681–691.

    Article  Google Scholar 

  • Estes, A., Munson, J., Dawson, G., Koehler, E., Zhou, X. H., & Abbott, R. (2009). Parenting stress and psychological functioning among mothers of preschool children with autism and developmental delay. Autism, 13(4), 375–387.

    Article  PubMed  Google Scholar 

  • Falkmer, T., Anderson, K., Falkmer, M., & Horlin, C. (2013). Diagnostic procedures in autism spectrum disorders: a systematic literature review. European Child and Adolescent Psychiatry, 22(6), 329–340.

    Article  PubMed  Google Scholar 

  • Farmer, C., et al. (2015). Aggression in children with autism spectrum disorders and a clinic-referred comparison group. Autism, 19(3), 281–291.

    Article  PubMed  Google Scholar 

  • Fisman, S., Wolf, L., Ellison, D., & Freeman, T. (2000). A longitudinal study of siblings of children with chronic disabilities. The Canadian Journal of Psychiatry, 45(4), 369–375.

    Article  PubMed  Google Scholar 

  • Flaherty, D. K. (2011). The vaccine-autism connection: A public health crisis caused by unethical medical practices and fraudulent science. Annals of Pharmacotherapy, 45(10), 1302–1304.

    Article  PubMed  Google Scholar 

  • Fombonne, E. (2005). The changing epidemiology of autism. Journal of Applied Research in Intellectual Disabilities, 18(4), 281–294.

    Article  Google Scholar 

  • Frith, U. (1991). Asperger and his syndrome. In U. Frith (Ed.), Autism and Asperger Syndrome (pp. 1–36). Cambridge, MA: Cambridge University Press.

    Chapter  Google Scholar 

  • Ganz, M. L. (2007). The lifetime distribution of the incremental societal costs of autism. Archives of Pediatrics & Adolescent Medicine, 161(4), 343–349.

    Article  Google Scholar 

  • Gardener, H., Spiegelman, D., & Buka, S. L. (2011). Perinatal and neonatal risk factors for autism: A comprehensive meta-analysis. Pediatrics, 128(2), 344–355.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gaugler, T., Klei, L., Sanders, S. J., Bodea, C. A., Goldberg, A. P., Lee, A. B., … Ripke, S. (2014). Most genetic risk for autism resides with common variation. Nature Genetics, 46(8), 881–885.

    Article  PubMed  PubMed Central  Google Scholar 

  • Geschwind, D. H. (2011). Genetics of autism spectrum disorders. Trends in Cognitive Sciences, 15(9), 409–416.

    Article  PubMed  PubMed Central  Google Scholar 

  • Geschwind, D. H., & Levitt, P. (2007). Autism spectrum disorders: Developmental disconnection syndromes. Current Opinion in Neurobiology, 17(1), 103–111.

    Article  PubMed  Google Scholar 

  • Gowen, E., & Hamilton, A. (2013). Motor abilities in autism: A review using a computational context. Journal of Autism and Developmental Disorders, 43(2), 323–344.

    Article  PubMed  Google Scholar 

  • Gurney, J. G., McPheeters, M. I., & Davis, M. M. (2006). Parental report of health conditions and health care use among children with and without autism. Archives of Pediatric and Adolescent Medicine, 160(8), 825–830.

    Article  Google Scholar 

  • Gurney, J. G., Fritz, M. S., Ness, K. K., Sievers, P., Newschaffer, C. J., & Shapiro, E. G. (2003). Analysis of prevalence trends of autism spectrum disorder in Minnesota. Archives of Pediatrics and Adolescent Medicine, 157(7), 622–627.

    Article  PubMed  Google Scholar 

  • Guthrie, W., Swineford, L. B., Nottke, C., & Wetherby, A. M. (2013). Early diagnosis of autism spectrum disorder: Stability and change in clinical diagnosis and symptom presentation. Journal of Child Psychology and Psychiatry, 54(5), 582–590.

    Article  PubMed  Google Scholar 

  • Hall, H. R., & Graff, J. C. (2011). The relationships among adaptive behaviors of children with autism, family support, parenting stress, and coping. Issues in Comprehensive Pediatric Nursing, 34(1), 4–25.

    Article  PubMed  Google Scholar 

  • Hallmayer, J., Cleveland, S., Torres, A., Phillips, J., Cohen, B., Torigoe, T., … Risch, N. (2011). Genetic heritability and shared environmental factors among twin pairs with autism. Archives of General Psychiatry, 68(11), 1095–1102.

    Article  PubMed  PubMed Central  Google Scholar 

  • Happé, F., & Frith, U. (2006). Weak coherence account: Detail-focused cognitive style in autism spectrum disorders. Journal of Autism and Developmental Disorders, 36(1), 5–25.

    Article  PubMed  Google Scholar 

  • Hartley, S. L., Barker, E. T., Seltzer, N. M., Floyd, F., Greenberg, J., Orsmond, G., & Bolt, D. (2010). The relative risk and timing of divorce in families of children with an autism spectrum disorder. Journal of Family Psychology, 24(4), 449–457.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hastings, R. P. (2003). Child behavior problems and partner mental health as correlates of stress in mothers and fathers of children with autism. Journal of Intellectual Disability Research, 47(4–5), 231–237.

    Article  PubMed  Google Scholar 

  • Hazen, E. P., Stornelli, J. L., O’Rourke, J. A., Koesterer, K., & McDougle, C. J. (2014). Sensory symptoms in autism spectrum disorder. Harvard Review of Psychiatry, 22(2), 112–124.

    Article  PubMed  Google Scholar 

  • Hill, A. P., Zuckerman, K. E., Hagen, A. D., Kriz, D. J., Duvall, S. W., van Santen, J., … Fombonne, E. (2014). Aggressive behavior problems in children with autism spectrum disorders: Prevalence and correlates in a large clinical sample. Research in Autism Spectrum Disorders, 8(9), 1121–1133.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hobson, R. P., Lee, A., & Hobson, J. A. (2008). Qualities of symbolic play among children with autism: A social-developmental perspective. Journal of Autism and Developmental Disorders, 39(1), 12–22.

    Article  PubMed  Google Scholar 

  • Hoffman, C. D., Sweeney, D. P., Hodge, D., Lopez-Wagner, M. C., & Looney, L. (2009). Parenting stress and closeness: Mothers of typically developing children and mothers of children with autism. Focus on Autism and Other Developmental Disabilities, 24(3), 178–187.

    Article  Google Scholar 

  • Honda, H., Shimizu, Y., & Rutter, M. (2005). No effect of MMR withdrawal on the incidence of autism: A total population study. Journal of Child Psychology and Psychiatry, 46(6), 572–579.

    Article  PubMed  Google Scholar 

  • Horner, R. H., Carr, E. G., Strain, P. S., Todd, A. W., & Reed, H. K. (2002). Problem behavior interventions for young children with autism: A research synthesis. Journal of Autism and Developmental Disorders, 32(5), 423–446.

    Article  PubMed  Google Scholar 

  • Howlin, P. (2003). Outcome in high-functioning adults with autism with and without early language delays: Implications for the differentiation between autism and Asperger syndrome. Journal of Autism and Developmental Disorders, 33(1), 3–13.

    Article  PubMed  Google Scholar 

  • Ingersoll, B., & Hambrick, D. Z. (2011). The relationship between the broader autism phenotype, child severity, and stress and depression in parents of children with autism spectrum disorders. Research in Autism Spectrum Disorders, 5(1), 337–344.

    Article  Google Scholar 

  • Johnson, C., & Myers, S. (2007). Identification and evaluation of children with autism spectrum disorders. AAP Policy, 120(5), 1183–1215.

    Google Scholar 

  • Jones, E. J., Gliga, T., Bedford, R., Charman, T., & Johnson, M. H. (2014). Developmental pathways to autism: A review of prospective studies of infants at risk. Neuroscience & Biobehavioral Reviews, 39, 1–33.

    Article  Google Scholar 

  • Joseph, R. M., Tager-Flusberg, H., & Lord, C. (2002). Cognitive profiles and social-communicative functioning in children with autism spectrum disorder. Journal of Child Psychology and Psychiatry, 4(6), 807–821.

    Article  Google Scholar 

  • Kaminsky, L., & Dewey, D. (2002). Psychosocial adjustment in siblings of children with autism. Journal of Child Psychology and Psychiatry, 43(2), 225–232.

    Article  PubMed  Google Scholar 

  • Kanne, S. M., Gerber, A. J., Quirmback, L. M., Sparrow, S. S., Cicchetti, D. V., & Saulnier, C. A. (2011). The role of adaptive behavior in autism spectrum disorders: Implications for functional outcome. Journal of Autism and Developmental Disorders, 41, 1007–1018.

    Article  PubMed  Google Scholar 

  • Kanne, S. M., & Mazurek, M. O. (2011). Aggression in children and adolescents with ASD: Prevalence and risk factors. Journal of Autism & Developmental Disorders, 41(7), 926–937.

    Article  Google Scholar 

  • Kanner, L. (1943). Autistic disturbances of affective contact. The Nervous Child, 2(2), 217–250.

    Google Scholar 

  • Karst, J. S., & Van Hecke, A. V. (2012). Parent and family impact of autism spectrum disorders: A review and proposed model for intervention evaluation. Clinical Child and Family Psychology Review, 15(3), 247–277.

    Article  PubMed  Google Scholar 

  • Kent, R., & Simonoff, E. (2017). Prevalence of anxiety in autism spectrum disorders. In C. M. Kerns, P. Renno, E. A. Storch, P. C. Kendall, & W. Jeffrey (Eds.), Anxiety in children and adolescents with autism spectrum disorder: Evidence-based assessment and treatment. London: Elsevier Science.

    Google Scholar 

  • Kerns, C. M., & Kendall, P. C. (2012). The presentation and classification of anxiety and autism spectrum disorder. Clinical Psychology: Science and Practice, 19(4), 323–347.

    Google Scholar 

  • Kim, J., Campbell, B., Mahoney, N., Chan, K., Molyneux, R., & May, G. (2008). Chemosensitization prevents tolerance of Aspergillus fumigatus to antimycotic drugs. Biochemical and Biophysical Research Communications, 372(1), 266–271.

    Article  PubMed  Google Scholar 

  • Kim, S. H., Paul, R., Tager-Flushberg, H., & Lord, C. (2014). Language and communication in autism in. In F. R. Volkmar, R. Paul, S. J. Rogers, K. A. Pelphrey, S. J. Rogers, & K. A. Pelphrey (Eds.), Handbook of autism and pervasive developmental disorders (pp. 230–262). Hoboken, NJ: John Wiley & Sons, Inc.

    Google Scholar 

  • King, M., & Bearman, P. (2009). Diagnostic change and the increased prevalence of autism. International Journal of Epidemiology, 38(5), 1224–1234.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kirkovski, M., Enticott, P. G., & Fitzgerald, P. B. (2013). A review of the role of female gender in autism spectrum disorders. Journal of Autism and Developmental Disorders, 43(11), 2584–2603.

    Article  PubMed  Google Scholar 

  • Klin, A. (1991). Young autistic children’s listening preferences in regard to speech: A possible characterization of the symptom of social withdrawal. Journal of Autism and Developmental Disorders, 21(1), 29–42.

    Article  PubMed  Google Scholar 

  • Klin, A. (2011). Asperger’s syndrome: From Asperger to modern day. In D. Amaral, D. Geschwind, & G. Dawson (Eds.), Autism spectrum disorders (pp. 44–59). New York, NY: Oxford University Press.

    Chapter  Google Scholar 

  • Klin, A., Saulnier, C. A., Sparrow, S. S., Cicchetti, D. V., Volkmar, F. R., & Lord, C. (2007). Social and communication abilities and disabilities in higher functioning individuals with autism spectrum disorders: The Vineland and the ADOS. Journal of Autism and Developmental Disorders, 37(4), 748–759.

    Article  PubMed  Google Scholar 

  • Kogan, M. D., Strickland, B. B., Blumberg, S. J., Singh, G. K., Perrin, J. M., & van Dyck, P. C. (2008). A national profile of the health care experiences and family impact of autism spectrum disorder among children in the United States, 2005–2006. Pediatrics, 122(6), 1149–1158.

    Article  Google Scholar 

  • Kolvin, I. (1971). Studies in the childhood psychoses. I. Diagnostic criteria and classification. The British Journal of Psychiatry, 118(545), 381–384.

    Article  PubMed  Google Scholar 

  • Laidler, J. R. (2004). The “Refrigerator Mother” hypothesis of autism. Autism Watch

    Google Scholar 

  • Lauritsen, M. B., Pedersen, C. B., & Mortensen, P. B. (2005). Effects of familial risk factors and place of birth on the risk of autism: A nationwide register-based study. Journal of Child Psychology and Psychiatry, 46(9), 963–971.

    Article  PubMed  Google Scholar 

  • Lavelle, T. A., Weinstein, M. C., Newhouse, J. P., Munir, K., Kuhlthau, K. A., & Prosser, L. A. (2014). Economic burden of childhood autism spectrum disorders. Pediatrics, 133(3), 520–529.

    Article  Google Scholar 

  • Lee, L. C., Harrington, R. A., Louie, B. B., & Newschaffer, C. J. (2008). Children with autism.: Quality of life and parental concerns. Journal of Autism and Developmental Disorders, 38(6), 1147–1160.

    Article  PubMed  Google Scholar 

  • Levisohn, P. M. (2007). The autism-epilepsy connection. Epilepsia, 48(9), 33–35.

    Article  PubMed  Google Scholar 

  • Li, Y. M., Ou, J. J., Liu, L., Zhang, D., Zhao, J. P., & Tang, S. Y. (2016). Association between maternal obesity and autism spectrum disorder in offspring: A meta-analysis. Journal of Autism and Developmental Disorders, 46(1), 95–102.

    Article  PubMed  Google Scholar 

  • Lichtenstein, P., Carlstrom, E., Rastam, M., Gillberg, C., & Anckarsater, H. (2010). The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood. American Journal of Psychiatry, 167(11), 1357–1363.

    Article  PubMed  Google Scholar 

  • Lord, C., & Paul, R. (1997). Language and communication in autism. In D. Cohen & F. Volkmar (Eds.), Handbook of autism and pervasive developmental disorders (2nd ed., pp. 195–225). New York, NY: Wiley.

    Google Scholar 

  • Losh, M., Adolphs, R., Poe, M. D., Couture, S., Penn, D., Baranek, G. T., & Piven, J. (2009). Neuropsychological profile of autism and the broad autism phenotype. Archives of General Psychiatry, 66(5), 518–526.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lotter, V. (1966). Epidemiology of autistic conditions in young children. Social Psychiatry and Psychiatric Epidemiology, 1(3), 124–135.

    Google Scholar 

  • Macari, S. L., Campbell, D., Gengoux, G. W., Saulnier, C. A., Klin, A. J., & Chawarska, K. (2012). Predicting developmental status from 12 to 24 months in infants at risk for autism spectrum disorder: A preliminary report. Journal of Autism and Developmental Disorders, 42(12), 2636–2647.

    Article  PubMed  PubMed Central  Google Scholar 

  • Macks, R. J., & Reeve, R. E. (2007). The adjustment of non-disabled siblings of children with autism. Journal of Autism and Developmental Disorders, 37(6), 1060–1067.

    Article  PubMed  Google Scholar 

  • Magiati, I., Tay, X. W., & Howlin, P. (2014). Cognitive, language, social and behavioral outcomes in adults with autism spectrum disorders: A systematic review of longitudinal follow-up studies in adulthood. Clinical Psychology Review, 34(1), 73–86.

    Article  PubMed  Google Scholar 

  • Mandy, W., & Lai, M. C. (2016). Annual research review: The role of the environment in the developmental psychopathology of autism spectrum condition. Journal of Child Psychology and Psychiatry, 57(3), 271–292.

    Article  PubMed  Google Scholar 

  • Marí-Bauset, S., Zazpe, I., Mari-Sanchis, A., Llopis-González, A., & Morales-Suárez-Varela, M. (2014). Evidence of the gluten-free and casein-free diet in autism spectrum disorders: A systematic review. Journal of Child Neurology, 29(12), 1718–1727.

    Article  PubMed  Google Scholar 

  • Marshall, C. R., Noor, A., Vincent, J. B., Lionel, A. C., Feuk, L., Skaug, J., … Thiruvahindrapduram, B. (2008). Structural variation of chromosomes in autism spectrum disorder. The American Journal of Human Genetics, 82(2), 477–488.

    Article  PubMed  Google Scholar 

  • Matson, J. L., & Shoemaker, M. (2009). Intellectual disability and its relationship to autism spectrum disorders. Research in Developmental Disabilities, 30(6), 1107–1114.

    Article  PubMed  Google Scholar 

  • Mayes, S. D., Calhoun, S. L., Aggarwal, R., Baker, C., Mathapati, S., Molitoris, S., & Mayes, R. D. (2013). Unusual fears in children with autism. Research in Autism Spectrum Disorders, 7(1), 151–158.

    Article  Google Scholar 

  • Mazefsky, C. A., Borue, X., Day, T. N., & Minshew, N. J. (2014). Emotion regulation patterns in adolescents with high-functioning autism spectrum disorder: Comparison to typically developing adolescents and association with psychiatric symptoms. Autism Research, 7(3), 344–354.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mazurek, M. O., Kanne, S. M., & Wodka, E. L. (2013). Physical aggression in children and adolescents with autism spectrum disorders. Research in Autism Spectrum Disorders, 7(3), 455–465.

    Article  Google Scholar 

  • McElhanon, B. O., McCracken, C., Karpen, S., & Sharp, W. G. (2014). Gastrointestinal symptoms in autism spectrum disorder: A meta-analysis. Pediatrics, 133(5), 872–883.

    Article  PubMed  Google Scholar 

  • McTiernan, A., Leader, G., Healy, O., & Mannion, A. (2011). Analysis of risk factors and early predictors of challenging behavior for children with autism spectrum disorder. Research in Autism Spectrum Disorders, 5(3), 1215–1222.

    Article  Google Scholar 

  • Meadan, H., Stoner, J. B., & Angell, M. E. (2010). Review of literature related to the social, emotional, and behavioral adjustment of siblings of individuals with autism spectrum disorder. Journal of Developmental and Physical Disabilities, 22(1), 83–100.

    Article  Google Scholar 

  • Millward, C., Ferriter, M., Calver, S. J., & Connell-Jones, G. G. (2009). Gluten-and casein-free diets for autistic spectrum disorder. Cochrane Database Systematic Review, 2, 1–29.

    Google Scholar 

  • Mindspec (2017). Informatics for neurodevelopmental disorders. Retrieved from http://www.mindspec.org

  • Ming, X., Brimacombe, M., & Wagner, G. C. (2007). Prevalence of motor impairment in autism spectrum disorders. Brain and Development, 29(9), 565–570.

    Article  PubMed  Google Scholar 

  • Minshew, N. J., & Williams, D. L. (2007). The new neurobiology of autism: Cortex, connectivity, and neuronal organization. Advancing Brain and Nervous System Science, 64(7), 945–950.

    Google Scholar 

  • Morrier, M. J., Hess, K. L., & Heflin, L. J. (2008). Ethnic disproportionality in students with autism spectrum disorders. Multicultural Education, 16(1), 31–38.

    Google Scholar 

  • Mottron, L., Peretz, I., & Ménard, E. (2000). Local and global processing of music in high-functioning persons with autism: Beyond central coherence? Journal of Child Psychology and Psychiatry, 41(8), 1057–1065.

    Article  PubMed  Google Scholar 

  • Mugno, D., Ruta, L., D’Arrigo, V. G., & Mazzone, L. (2007). Impairment of quality of life in parents of children and adolescents with pervasive developmental disorder. Health and Quality of Life Outcomes, 5(22), 1–9.

    Google Scholar 

  • Nadig, A. S., Ozonoff, S., Young, G. S., Rozga, A., Sigman, M., & Rogers, S. J. (2007). A prospective study of response to name in infants at risk for autism. Archives of Pediatrics and Adolescent Medicine, 161(4), 378–383.

    Article  PubMed  Google Scholar 

  • National Research Council. (2001). Educating children with autism. Washington, DC: National Academy Press.

    Google Scholar 

  • Norrelgen, F., Fernell, E., Eriksson, M., Hedvall, A., Persson, C., Sjölin, M., … Kjellmer, L. (2014). Children with autism spectrum disorders who do not develop phrase speech in the preschool years. Autism, 19(8), 934–943.

    Article  PubMed  Google Scholar 

  • Olsson, M. B., & Hwang, C. P. (2001). Depression in mothers and fathers of children with intellectual disabilities. Journal of Intellectual Disability Research, 45(6), 535–543.

    Article  PubMed  Google Scholar 

  • Ousley, O., & Cermak, T. (2014). Autism spectrum disorder: Defining dimensions and subgroups. Current Developmental Disorders Reports, 1(1), 20–28.

    Article  PubMed  Google Scholar 

  • Ozonoff, S., Macari, S., Young, G. S., Goldring, S., Thompson, M., & Rogers, S. J. (2008). Atypical object exploration at 12 months of age is associated with autism in a prospective sample. Autism, 12(5), 457–472.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ozonoff, S., & Stayer, D. L. (2001). Further evidence of intact working memory in autism. Journal of Autism and Developmental Disorders, 31(3), 257–263.

    Article  PubMed  Google Scholar 

  • Paul, R. (2009). Interventions to improve communication. Child and Adolescent Psychiatric Clinics of North America, 17(4), 835–856.

    Article  Google Scholar 

  • Persico, A. M., & Napolioni, V. (2013). Autism genetics. Behavioral Brain Research, 251, 95–112.

    Article  Google Scholar 

  • Piazza, C. C. (2008). Feeding disorders and behavior: What have we learned? Developmental Disabilities Research Reviews, 14(2), 171–181.

    Article  Google Scholar 

  • Piazza, C. C., Fisher, W. W., Brown, K. A., Shore, B. A., Patel, M. R., Katz, R. M., … Blakely-Smith, A. (2003). Functional analysis of inappropriate mealtime behaviors. Journal of Applied Behavior Analysis, 36(2), 187–204.

    Article  PubMed  PubMed Central  Google Scholar 

  • Plant, K. M., & Sanders, M. R. (2007). Predictors of care-giver stress in families of preschool-aged children with developmental disabilities. Journal of Intellectual Disability Research, 51(2), 109–124.

    Article  PubMed  Google Scholar 

  • Pottie, C. G., & Ingram, K. M. (2008). Daily stress, coping, and well-being in parents of children with autism: A multilevel modeling approach. Journal of Family Psychology, 22(6), 855–864.

    Article  PubMed  Google Scholar 

  • Prizant, B. M., Wetherby, A. M., Rubin, E., & Laurent, A. C. (2003). The SCERTS model: A transactional, family-centered approach to enhancing communication and socioemotional abilities of children with autism spectrum disorder. Infants and Young Children, 16(4), 296–316.

    Article  Google Scholar 

  • Provost, B., Crowe, T. K., Osbourn, P. L., McClain, C., & Skipper, B. J. (2010). Mealtime behaviors of preschool children: Comparison with autism spectrum disorder and children with typical development. Physical and Occupational Therapy in Pediatrics, 30(3), 220–233.

    Article  PubMed  Google Scholar 

  • Reichelt, K. L., Knivsberg, A. M., Lind, G., & Nodland, M. (1991). Probable etiology and possible treatment of childhood autism. Brain Dysfunction, 4(6), 308–319.

    Google Scholar 

  • Reichenberg, A., Gross, R., Weiser, M., Bresnahan, M., Silverman, J., Harlap, S., … Knobler, H. Y. (2006). Advancing paternal age and autism. Archives of General Psychiatry, 63(9), 1026–1032.

    Article  PubMed  Google Scholar 

  • Reiersen, A. M., & Todd, R. D. (2011). Attention-deficit/hyperactivity disorder (ADHD). In D. G. Amaral, G. Dawson, & D. H. Geschwind (Eds.), Autism spectrum disorders. New York, NY: Oxford University Press, Inc.

    Google Scholar 

  • Richler, J., Luyster, R., Risi, S., Hsu, W. L., Dawson, G., Bernier, R., … McMahon, W. M. (2006). Is there a ‘regressive phenotype’ of autism spectrum disorder associated with the measles-mumps-rubella vaccine? A CPEA study. Journal of Autism and Developmental Disorders, 36(3), 299–316.

    Article  PubMed  Google Scholar 

  • Ross, P., & Cuskelly, M. (2006). Adjustment, sibling problems and coping strategies of brothers and sisters of children with autistic spectrum disorder. Journal of Intellectual & Developmental Disability, 32(2), 77–86.

    Article  Google Scholar 

  • Rossignol, D. A., & Frye, R. E. (2012). A review of research trends in physiological abnormalities in autism spectrum disorders: Immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures. Molecular Psychiatry, 17(4), 389–401.

    Article  PubMed  Google Scholar 

  • Rutter, M. (1968). Concepts of autism: A review of research. Journal of Child Psychology and Psychiatry, 9(1), 1–25.

    Article  PubMed  Google Scholar 

  • Ryan, P. M., Kaskas, M. M., & Davis, T. E. (2017). Anxiety in children and adolescents with autism spectrum disorders. In C. M. Kerns, P. Renno, E. A. Storch, P. C. Kendall, & J. J. Wood (Eds.), Cognitive behavioral principals and their application with autism spectrum disorder (pp. 105–121). London: UK: Elsevier.

    Google Scholar 

  • Sacrey, L. A., Zwaigenbaum, L., Bryson, S., Brian, J., Smith, I. M., Roberts, W., … Armstrong, V. (2015). Can parents’ concerns predict autism spectrum disorder? A prospective study of high-risk siblings from 6 to 36 months of age. Journal of the American Academy of Child and Adolescent Psychiatry, 54(6), 470–478.

    Article  PubMed  Google Scholar 

  • Sandin, S., Hultman, C. M., Kolevzon, A., Gross, R., MacCabe, J. H., & Reichenberg, A. (2012). Advancing maternal age is associated with increasing risk for autism: A review and meta-analysis. Journal of the American Academy of Child & Adolescent Psychiatry, 51(5), 477–486.

    Article  Google Scholar 

  • Santamaria, F., Cuzzocrea, F., Gugliandolo, M. C., & Larcan, R. (2012). Marital satisfaction and attribution style in parents of children with autism spectrum disorder, Down syndrome and non-disabled children. Life Span and Disability, 15(1), 19–37.

    Google Scholar 

  • Sasson, N. J., Pinkham, A. E., Carpenter, K. L., & Belger, A. (2010). The benefit of directly comparing autism and schizophrenia for revealing mechanisms of social cognitive impairment. Journal of Neurodevelopmental Disorders, 3(2), 87.

    Article  PubMed  PubMed Central  Google Scholar 

  • Schaefer, G. B., & Mendelsohn, N. J. (2008). Genetics evaluation for the etiologic diagnosis of autism spectrum disorders. Genetics in Medicine, 10(1), 4–12.

    Article  PubMed  Google Scholar 

  • Schroeder, J. H., Cappadocia, M. C., Bebko, J. M., Pepler, D. J., & Weiss, J. A. (2014). Shedding light on a pervasive problem: A review of research on bullying experiences among children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 44(7), 1520–1534.

    Article  PubMed  Google Scholar 

  • Sebat, J., Lakshmi, B., Malhotra, D., Troge, J., Lese-Martin, C., Walsh, T., … Wigler, M. (2007). Strong association of de novo copy number mutations with autism. Science, 445(9), 445–449.

    Article  Google Scholar 

  • Seidman, I., Yirmiya, N., Milshtein, S., Ebstein, R. P., & Levi, S. (2012). The broad autism phenotype questionnaire: Mothers versus fathers of children with an autism spectrum disorder. Journal of Autism and Development Disorders, 42(5), 837–846.

    Article  Google Scholar 

  • SFARI Gene (2017). Retrieved from http://www.gene.safari.org

  • Sharp, W. G., Berry, R. C., McElhanon, C. O., & Jaquess, D. (2013). Dietary diversity in children with Autism. In V. B. Patel, V. R. Preedy, & C. R. Martin (Eds.), Comprehensive guide to autism (pp. 2077–2097). New York, NY: Springer.

    Google Scholar 

  • Shriberg, L. D., Paul, R., Black, L. M., & Van Santen, J. P. (2011). The hypothesis of apraxia of speech in children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 41(4), 405–426.

    Article  PubMed  PubMed Central  Google Scholar 

  • Shriberg, L. D., Paul, R., McSweeny, J. L., Klin, A., Cohen, D. J., & Volkmar, F. R. (2001). Speech and prosody characteristics of adolescents and adults with high-functioning autism and Asperger syndrome. Journal of Speech, Language, and Hearing Research, 44(5), 1097–1115.

    Article  PubMed  Google Scholar 

  • Souders, M. C., Mason, T. B., Valladares, O., Bucan, M., Levy, S. E., Mandell, D. S., … Pinto-Martin, J. (2009). Sleep behaviors and sleep quality in children with autism spectrum disorders. Sleep, 32(12), 1566–1578.

    Article  PubMed  PubMed Central  Google Scholar 

  • Streit, W. J., Mrak, R. E., & Griffin, W. S. (2004). Microglia and neuroinflammation: A pathological perspective. Journal of Neuroinflammation, 1(1), 1–4.

    Article  Google Scholar 

  • Symon, J. B. (2001). Parent education for autism: Issues in providing services at a distance. Journal of Positive Behavior Interventions, 3(3), 160–174.

    Article  Google Scholar 

  • Tanne, J. H. (2012). Maternal obesity and diabetes are linked to children’s autism and similar disorders. British Medical Journal, 17, 344.

    Google Scholar 

  • Thurm, A., Powell, E. M., Neul, J. L., Wagner, A., & Zwaigenbaum, L. (2017). Loss of skills and onset patterns in neurodevelopmental disorders: Understanding the neurobiological mechanisms. Autism Research.

    Google Scholar 

  • Volkmar, F. R. (Ed.). (2013). Encyclopedia of autism spectrum disorder. New York, NY: Springer Science and Business Media.

    Google Scholar 

  • Wakefield, A. J., & Montgomery, S. M. (2000). Measles, mumps, rubella, vaccine: Through a glass, darkly. Adverse Drug Reactions and Toxicological Reviews, 19(4), 265–283.

    PubMed  Google Scholar 

  • Wakefield, A. J., Murch, S. H., Anthony, A., Linnell, J., Casson, D. M., Malik, M., … Walker-Smith, J. A. (1998). Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. The Lancet Child and Adolescent Health, 351(9103), 637–641.

    Google Scholar 

  • Watt, N., Wetherby, A. M., Barber, A., & Morgan, L. (2008). Repetitive and stereotyped behaviors in children with autism spectrum disorders in the second year of life. Journal of Autism and Developmental Disorders, 38(8), 1518–1533.

    Article  PubMed  PubMed Central  Google Scholar 

  • Weiss, K. (2009). Toxin-binding treatment for Clostridium difficile: A review including reports of studies with tolevamer. International Journal of Antimicrobial Agents, 33(1), 4–7. https://doi.org/10.1016/j.ijantimicag.2008.07.011

    Article  PubMed  Google Scholar 

  • Wellman, H. K., Cross, D., & Watson, J. (2001). Meta-analysis of theory-of-mind development: The truth about false belief. Child Development, 72(3), 655–684.

    Article  PubMed  Google Scholar 

  • Werner, E., & Dawson, G. (2005). Validation of the phenomenon of autistic regression using home videotapes. Archives of General Psychiatry, 62(8), 889–895.

    Article  PubMed  Google Scholar 

  • Wetherby, A. M., Woods, J., Allen, L., Cleary, J., Dickinson, H., & Lord, C. (2004). Early indicators of autism spectrum disorders in the second year of life. Journal of Autism and Developmental Disorders, 34(5), 473–493.

    Article  PubMed  Google Scholar 

  • Wiggins, L. D., Robins, D. L., Adamson, L. B., Bakeman, R., & Henrich, C. C. (2012). Support for a dimensional view of autism spectrum disorders in toddlers. Journal of Autism and Developmental Disorders, 42(2), 191–200.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wing, L., & Potter, D. (2002). The epidemiology of autism spectrum disorders: Is the prevalence rising? Developmental Disabilities Research Reviews, 8(3), 151–161.

    Article  Google Scholar 

  • Woodman, A. C., Mawdsley, H. P., & Hauser-Cram, P. (2015). Parenting stress and child behavior problems within families of children with developmental disabilities: Transactional relations across 15 years. Research in Developmental Disabilities, 36, 264–276.

    Article  Google Scholar 

  • World Health Organization (2017). Autism spectrum disorders: Fact sheet. Retrieved from http://www.who.int/mediacentre/factsheets/autism-spectrum-disorders/en/

  • Xu, G., Jing, J., Bowers, K., Liu, B., & Bao, W. (2014). Maternal diabetes and the risk of autism spectrum disorders in the offspring: A systematic review and meta-analysis. Journal of Autism and Developmental Disorders, 44(4), 766–775.

    Article  PubMed  PubMed Central  Google Scholar 

  • Zablotsky, B., Black, L. I., Maenner, M. J., Schieve, L. A., & Blumberg, S. J. (2015). Estimated prevalence of autism and other developmental disabilities following questionnaire changes in the 2014 National Health Interview Survey.

    Google Scholar 

  • Zafeiriou, D. I., Ververi, A., Dafoulis, V., Kalyva, E., & Vargiami, E. (2013). Autism spectrum disorders: The quest for genetic syndromes. American Journal of Medical Genetics Part B, 162(4), 327–366.

    Article  Google Scholar 

  • Zager, D., Cihak, D. F., & Stone-MacDonald, A. (2017). Definitions and classifications of autism spectrum disorders. In A. Stone-MacDonald (Ed.), Autism spectrum disorders: Identification, education, and treatment (pp. 1–22). New York, NY: Routledge.

    Google Scholar 

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Rea, H., LaMotte, K., Burrell, T.L. (2018). What Is Autism Spectrum Disorder?. In: McNeil, C., Quetsch, L., Anderson, C. (eds) Handbook of Parent-Child Interaction Therapy for Children on the Autism Spectrum. Springer, Cham. https://doi.org/10.1007/978-3-030-03213-5_1

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