Abstract
In the nineteenth century, a French researcher, Charles-Marie Benjamin Rouget, revealed a population of contractile cells associated with small blood vessels, which were initially named after him as the Rouget cells. In the twentieth century, a German scientist, Karl Wilhelm Zimmermann, called these cells “pericytes” due to their anatomical position located in a perivascular position. The word pericyte was derived from “peri” meaning “around” and “cyte” from the word “kytos” (cell), illustrating a cell encircling a blood vessel. Until now, pericytes are still identified partially based on their specific anatomical location and morphology. Pericytes are present in all vascularized tissues, surrounding blood vessel walls. They encircle endothelial cells and communicate with them along the length of the blood vessels by paracrine signaling and physical contacts. Previously, the accurate distinction of pericytes from other perivascular cells was difficult, as electron and light microscopy were the sole available techniques capable to image these cells, limiting the information acquired from those works. This resulted in the misleading assumption that pericytes are merely inert supporting cells, limited exclusively to the physiological function of vascular stability. In the last 10 years, the combination of fluorescent and confocal microscopy with genetic state-of-art techniques, such as fate lineage tracing, enabled remarkable progress in the discovery of multiple novel essential functions for pericytes in health and disease, before unexpected. Recently, the rapidly expanding understanding of the pathophysiological roles of pericytes drew the attention of several research groups. Now, we know, for instance, that pericytes may play immune functions: attract innate leukocytes to exit via sprouting blood vessels, regulate lymphocyte activation, and contribute to the clearance of toxic by-products, having direct phagocytic activity. Pericytes also may behave as stem cells, forming other cell populations, as well as regulate the behavior of other stem cells in their niches. Very little is known about the exact identity of pericyte ancestors within developing tissues, and there is evidence for multiple distinct developmental sources. Pericytes differ in their embryonic origins between tissues and also within the same organ. Importantly, pericytes from distinct tissues may differ in their distribution, morphology, expression of molecular markers, plasticity, and functions; and, even within the same organ, there are various pericyte subpopulations. This book describes the major contributions of pericytes to different organ biology in physiological and pathological conditions. Further insights into the biology of pericytes will have important implications for our understanding of organ development, homeostasis, and disease. This book’s initial title was “Pericyte Biology: Development, Homeostasis, and Disease.” However, due to the current great interest in this topic, we were able to assemble more chapters than would fit in one book, covering pericyte biology under distinct circumstances. Therefore, the book was subdivided into three volumes entitled: “Pericyte Biology: Novel Concepts,” “Pericyte Biology in Different Organs,” and “Pericyte Biology in Disease.” Here, we present a selected collection of detailed chapters on what we know so far about pericytes. More than 30 chapters written by experts in the field summarize our present knowledge on pericyte biology. Here, we present a selected collection of detailed chapters on what we know so far about pericytes. More than 30 chapters written by experts in the field summarize our present knowledge on pericyte biology.
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References
Alvarenga EC, Silva WN, Vasconcellos R, Paredes-Gamero EJ, Mintz A, Birbrair A (2018) Promyelocytic leukemia protein in mesenchymal stem cells is essential for leukemia progression. Ann Hematol 97:1749–1755
Andreotti JP, Paiva AE, Prazeres P, Guerra DAP, Silva WN, Vaz RS, Mintz A, Birbrair A (2018) The role of natural killer cells in the uterine microenvironment during pregnancy. Cell Mol Immunol https://doi.org/10.1038/s41423-018-0023-1
Armulik A, Genove G, Betsholtz C (2011) Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Dev Cell 21:193–215
Asada N, Kunisaki Y, Pierce H, Wang Z, Fernandez NF, Birbrair A, Ma’ayan A, Frenette PS (2017) Differential cytokine contributions of perivascular haematopoietic stem cell niches. Nat Cell Biol 19:214–223
Azevedo PO, Sena IFG, Andreotti JP, Carvalho-Tavares J, Alves-Filho JC, Cunha TM, Cunha FQ, Mintz A, Birbrair A (2018) Pericytes modulate myelination in the central nervous system. J Cell Physiol 233(8):5523–5529
Birbrair A, Borges IDT, Gilson Sena IF, Almeida GG, da Silva Meirelles L, Goncalves R, Mintz A, Delbono O (2017) How plastic are pericytes? Stem Cells Dev 26:1013–1019
Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O (2015) Pericytes at the intersection between tissue regeneration and pathology. Clin Sci 128:81–93
Borges I, Sena I, Azevedo P, Andreotti J, Almeida V, Paiva A, Santos G, Guerra D, Prazeres P, Mesquita LL et al (2017) Lung as a niche for hematopoietic progenitors. Stem Cell Rev 13:567–574
Castejon OJ (2011) Ultrastructural pathology of cortical capillary pericytes in human traumatic brain oedema. Folia Neuropathol 49:162–173
Dias Moura Prazeres PH, Sena IFG, Borges IDT, de Azevedo PO, Andreotti JP, de Paiva AE, de Almeida VM, de Paula Guerra DA, Pinheiro Dos Santos GS, Mintz A et al (2017) Pericytes are heterogeneous in their origin within the same tissue. Dev Biol 427:6–11
Diaz-Flores L, Gutierrez R, Varela H, Rancel N, Valladares F (1991) Microvascular pericytes: a review of their morphological and functional characteristics. Histol Histopathol 6:269–286
Hirschi KK, D’Amore PA (1996) Pericytes in the microvasculature. Cardiovasc Res 32:687–698
Khan JA, Mendelson A, Kunisaki Y, Birbrair A, Kou Y, Arnal-Estape A, Pinho S, Ciero P, Nakahara F, Ma'ayan A et al (2016) Fetal liver hematopoietic stem cell niches associate with portal vessels. Science 351:176–180
Rouget C (1873) Mémoire sur le développement, la structure et les proprietés physiologiques des capillaires sanguins et lymphatiques. Arch de Phys 5:603
Santos GSP, Prazeres P, Mintz A, Birbrair A (2018) Role of pericytes in the retina. Eye (Lond) 32(3):483–486
Schrimpf C, Teebken OE, Wilhelmi M, Duffield JS (2014) The role of pericyte detachment in vascular rarefaction. J Vasc Res 51:247–258
Sims DE (1991) Recent advances in pericyte biology – implications for health and disease. Can J Cardiol 7:431–443
Sims DE (2000) Diversity within pericytes. Clin Exp Pharmacol Physiol 27:842–846
Stark K, Eckart A, Haidari S, Tirniceriu A, Lorenz M, von Bruhl ML, Gartner F, Khandoga AG, Legate KR, Pless R et al (2013) Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and ‘instruct’ them with pattern-recognition and motility programs. Nat Immunol 14:41–51
Tu Z, Li Y, Smith DS, Sheibani N, Huang S, Kern T, Lin F (2011) Retinal pericytes inhibit activated T cell proliferation. Invest Ophthalmol Vis Sci 52:9005–9010
Zimmermann KW (1923) Der feinere Bau der Blutkapillaren. Z Anat Entwicklungsgesch 68:29–109
Acknowledgments
Alexander Birbrair is supported by a grant from Instituto Serrapilheira/Serra-1708-15285, a grant from Pró-reitoria de Pesquisa/Universidade Federal de Minas Gerais (PRPq/UFMG) (Edital 05/2016), a grant from National Institute of Science and Technology in Theranostics and Nanobiotechnology (CNPq/CAPES/FAPEMIG, Process No. 465669/2014-0), a grant from FAPEMIG [Rede Mineira de Engenharia de Tecidos e Terapia Celular (REMETTEC, RED-00570-16)], and a grant from FAPEMIG [Rede De Pesquisa Em Doenças Infecciosas Humanas E Animais Do Estado De Minas Gerais (RED-00313-16)].
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Birbrair, A. (2018). Pericyte Biology: Development, Homeostasis, and Disease. In: Birbrair, A. (eds) Pericyte Biology - Novel Concepts. Advances in Experimental Medicine and Biology, vol 1109. Springer, Cham. https://doi.org/10.1007/978-3-030-02601-1_1
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DOI: https://doi.org/10.1007/978-3-030-02601-1_1
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