How can we know what is right and wrong without referring to objective moral values? Pragmatic humanism suggests grounding moral obligations in the demands of sentient beings and the basic principle of preventing harm. Thus, it advocates a minimal and negative ethics with an experimental character: the moral order is the result of an ongoing process that aims at including and integrating a maximum of demands. Yet, exclusions and failures are unavoidably part of this process and have to be dealt with. Pragmatic humanism offers no ready-made solutions to moral problems but fosters moral autonomy.