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Chaperone-Like Proteins in Inflammation and Immunomodulation: Examples of Resistin and PPIases

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Chaperokine Activity of Heat Shock Proteins

Part of the book series: Heat Shock Proteins ((HESP,volume 16))

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Abstract

Hsp and other small proteins that function as an accessory chaperones interact with the cellular signaling network. They come up as an immediate response to stress when cells face the challenge of its own programmed death response. Chaperokines, with their inflammation and immune modulatory potential, try to strike the balance between recovery to normalcy and programmed death. Various disease pathways, environmental stresses, toxins and infections are the challenges that mount fatal stress. Resistin, an adipokine in murine model, small macrophage secreted protein in human and PPIases of Mycobacterium tuberculosis are the potential chaperokines. Though according to classical definition they do not fall under the category of HSP having α-crystalline domain, they function as small chaperone and are part of biological diversity where evolutionary conserved and adapted survival mechanisms work in parallel to protect and sustain life.

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Abbreviations

ATP:

Adenosine triphosphate

CAP-1:

Adenylyl cyclase-associated protein 1

Cyp:

Cyclophilin

E. coli :

Escherichia coli

ER:

Endoplasmic reticulum

FKBP:

FK506 binding protein

FoxP3:

Forkhead Box P3

hRes:

Human Resistin

HSP:

Heat shock protein family

Hsp:

Heat shock proteins

IL:

Interleukin

IRF-1:

Interferon regulatory factor 1

M.tb :

Mycobacterium tuberculosis

MIP:

Macrophage infectivity potentiator

NFAT:

Nuclear factor of activated T cells

NFκB:

Nuclear factor kappa B

PIN1:

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

PPIases:

Peptidyl-prolyl cis/trans isomerases

SDS:

Sodium dodecyl sulfate

SH3:

Src homology 3

TLR:

Toll-like receptors

TNF:

Tumor necrosis factor

Treg:

Regulatory T cells

UPR:

Unfolded protein response

WD40:

WD (Trp-Asp) or beta-transducin repeat motif

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Acknowledgements

NZE would like to thank Centre of Excellence research grant (BT/PR12817/COE/34/23/2015) from the Department of Biotechnology, Ministry of Science and Technology (DBT), Government of India and research grant (No.5/9/1019/2011-RHN) from ICMR, Ministry of Health and Family welfare, Government of India for financial support.

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Authors and Affiliations

  1. Inflammation Biology and Cell Signaling Laboratory, National Institute of Pathology, New Delhi, India

    Saurabh Pandey, Javeed Ahmad & Nasreen Zafar Ehtesham

  2. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Saurabh Pandey

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  1. Saurabh Pandey
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  2. Javeed Ahmad
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  3. Nasreen Zafar Ehtesham
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Editors and Affiliations

  1. Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Pandey, S., Ahmad, J., Ehtesham, N.Z. (2019). Chaperone-Like Proteins in Inflammation and Immunomodulation: Examples of Resistin and PPIases. In: Asea, A., Kaur, P. (eds) Chaperokine Activity of Heat Shock Proteins . Heat Shock Proteins, vol 16. Springer, Cham. https://doi.org/10.1007/978-3-030-02254-9_9

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