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Evidence-Based Procedural Dermatology pp 659–678Cite as

Soft Tissue Augmentation (Temporary Injectable Fillers) of the Lower Face and Neck (Lips, Perioral, Nose, Neck)

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Abstract

Soft tissue augmentation with injectable fillers is one of the most popular aesthetic procedures performed in the USA (US; V/B) (Ahn CS, Davis SA, Dabade TS, Williford PM, Feldman SR. Dermatol Surg 39(9):1351–9, 2013; Tierney EP, Hanke CW. Dermatol Surg 35(9):1324–33, 2009). The goal of these treatments is to either restore age- or disease-related volume loss or enhance and contour existing features, and the lower face is frequently an area of concern. In the aging face, bony remodeling, weakened retaining ligaments, and descent of atrophic fat pads contribute to the development of wrinkles and folds around the mouth, at the jawline, and at the chin. The nasolabial folds deepen; the lips thin; and the oral commissures turn down, delving into marionette lines. Bony resorption also makes the jawline less defined with a receding chin (Richard MJ, Morris C, Deen BF, Gray L, Woodward JA. Ophthal Plast Reconstr Surg 25(5):382–6, 2009; Rohrich RJ, Pessa JE. Plast Reconstr Surg 119(7):2219–27, 2007; Rohrich RJ, Pessa JE, Ristow B. Plast Reconstr Surg 121(6):2107–12, 2008; Shaw RB Jr, Katzel EB, Koltz PF, et al. Plast Reconstr Surg 127(1):374–83, 2011; Mendelson BC, Jacobson SR. Clin Plast Surg 35(3):395–404; 2008). Soft tissue augmentation seeks to soften these changes, particularly as part of a multimodal management plan with neuromodulators, resurfacing devices, and topical therapies (Carruthers J, Carruthers A. Dermatol Surg 42(Suppl 2):S89–93, 2016). On the flip side, younger patients also seek lower face enhancement, usually to correct genetically determined deficits such as nasal contour irregularities, to alter their face shapes, or to augment their features such as lips. This chapter evaluates the most commonly used injectable fillers in the USA to better understand the evidence-based literature supporting their safety and efficacy at the lower face, including the nasolabial folds, lips and perioral region, jawline and chin, nose, and neck and décolletage.

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References

  1. Ahn CS, Davis SA, Dabade TS, Williford PM, Feldman SR. Cosmetic procedures performed in the United States: a 16-year analysis. Dermatol Surg. 2013;39(9):1351–9.

    Article  CAS  PubMed  Google Scholar 

  2. Tierney EP, Hanke CW. Recent trends in cosmetic and surgical procedure volumes in dermatologic surgery. Dermatol Surg. 2009;35(9):1324–33.

    Article  CAS  PubMed  Google Scholar 

  3. Richard MJ, Morris C, Deen BF, Gray L, Woodward JA. Analysis of the anatomic changes of the aging facial skeleton using computer-assisted tomography. Ophthal Plast Reconstr Surg. 2009;25(5):382–6.

    Article  PubMed  Google Scholar 

  4. Rohrich RJ, Pessa JE. The fat compartments of the face: anatomy and clinical implications for cosmetic surgery. Plast Reconstr Surg. 2007;119(7):2219–27. discussion 2228–2231.

    Article  CAS  PubMed  Google Scholar 

  5. Rohrich RJ, Pessa JE, Ristow B. The youthful cheek and the deep medial fat compartment. Plast Reconstr Surg. 2008;121(6):2107–12.

    Article  CAS  PubMed  Google Scholar 

  6. Shaw RB Jr, Katzel EB, Koltz PF, et al. Aging of the facial skeleton: aesthetic implications and rejuvenation strategies. Plast Reconstr Surg. 2011;127(1):374–83.

    Article  CAS  PubMed  Google Scholar 

  7. Mendelson BC, Jacobson SR. Surgical anatomy of the midcheek: facial layers, spaces, and the midcheek segments. Clin Plast Surg. 2008;35(3):395–404. discussion 393.

    Article  PubMed  Google Scholar 

  8. Carruthers J, Carruthers A. A Multimodal Approach to Rejuvenation of the Lower Face. Dermatol Surg. 2016;42(Suppl 2):S89–93.

    Article  CAS  PubMed  Google Scholar 

  9. Day DJ, Littler CM, Swift RW, Gottlieb S. The wrinkle severity rating scale: a validation study. Am J Clin Dermatol. 2004;5(1):49–52.

    Article  PubMed  Google Scholar 

  10. Monheit GD, Gendler EC, Poff B, et al. Development and validation of a 6-point grading scale in patients undergoing correction of nasolabial folds with a collagen implant. Dermatol Surg. 2010;36(Suppl 3):1809–16.

    Article  CAS  PubMed  Google Scholar 

  11. Narins RS, Brandt F, Leyden J, Lorenc ZP, Rubin M, Smith S. A randomized, double-blind, multicenter comparison of the efficacy and tolerability of Restylane versus Zyplast for the correction of nasolabial folds. Dermatol Surg. 2003;29(6):588–95.

    PubMed  Google Scholar 

  12. Shoshani D, Markovitz E, Monstrey SJ, Narins DJ. The modified Fitzpatrick wrinkle scale: a clinical validated measurement tool for nasolabial wrinkle severity assessment. Dermatol Surg. 2008;34(Suppl 1):S85–91. discussion S91.

    CAS  PubMed  Google Scholar 

  13. Narins RS, Baumann L, Brandt FS, et al. A randomized study of the efficacy and safety of injectable poly-L-lactic acid versus human-based collagen implant in the treatment of nasolabial fold wrinkles. J Am Acad Dermatol. 2010;62(3):448–62.

    Article  CAS  PubMed  Google Scholar 

  14. Smith S, Busso M, McClaren M, Bass LS. A randomized, bilateral, prospective comparison of calcium hydroxylapatite microspheres versus human-based collagen for the correction of nasolabial folds. Dermatol Surg. 2007;33(Suppl 2):S112–21. discussion S121.

    CAS  PubMed  Google Scholar 

  15. Necas J, Bartosikova L, Brauner P, Kolar J. Hyaluronic acid (hyaluronan): a review. Veterinarni Medicina. 2008;53(8):397–411.

    Article  CAS  Google Scholar 

  16. Lin ZY, Shah V, Dhinakar A, Yildrimer L, Cui WG, Zhao X. Intradermal fillers for minimally invasive treatment of facial aging. Plast Aesthet Res. 2016;3:72–82.

    Article  Google Scholar 

  17. Narins RS, Dayan SH, Brandt FS, Baldwin EK. Persistence and improvement of nasolabial fold correction with nonanimal-stabilized hyaluronic acid 100,000 gel particles/ml filler on two retreatment schedules: results up to 18 months on two retreatment schedules. Dermatol Surg. 2008;34(Suppl 1):S2–8. discussion S8.

    CAS  PubMed  Google Scholar 

  18. Carruthers A, Carey W, De Lorenzi C, Remington K, Schachter D, Sapra S. Randomized, double-blind comparison of the efficacy of two hyaluronic acid derivatives, restylane perlane and hylaform, in the treatment of nasolabial folds. Dermatol Surg. 2005;31(11 Pt 2):1591–8. discussion 1598

    Article  CAS  PubMed  Google Scholar 

  19. Administration USFaD. Restylane(R) Lyst with Lidocaine. In: Administration USFaD, editors. Silver Springs: FDA Maryland; 2015.

    Google Scholar 

  20. Rzany B, Bayerl C, Bodokh I, et al. An 18-month follow-up, randomized comparison of effectiveness and safety of two hyaluronic acid fillers for treatment of moderate nasolabial folds. Dermatol Surg. 2017;43(1):58–65.

    Article  CAS  PubMed  Google Scholar 

  21. Rzany B, Bayerl C, Bodokh I, et al. Efficacy and safety of a new hyaluronic acid dermal filler in the treatment of moderate nasolabial folds: 6-month interim results of a randomized, evaluator-blinded, intra-individual comparison study. J Cosmet Laser Ther. 2011;13(3):107–12.

    Article  PubMed  Google Scholar 

  22. Ascher B, Bayerl C, Brun P, et al. Efficacy and safety of a new hyaluronic acid dermal filler in the treatment of severe nasolabial lines – 6-month interim results of a randomized, evaluator-blinded, intra-individual comparison study. J Cosmet Dermatol. 2011;10(2):94–8.

    Article  PubMed  Google Scholar 

  23. Ascher B, Bayerl C, Kestemont P, Rzany B, Edwartz C, Podda M. A 12-month follow-up, randomized comparison of effectiveness and safety of two hyaluronic acid fillers for treatment of severe nasolabial folds. Dermatol Surg. 2017;43(3):389–95.

    Article  CAS  PubMed  Google Scholar 

  24. Baumann LS, Shamban AT, Lupo MP, et al. Comparison of smooth-gel hyaluronic acid dermal fillers with cross-linked bovine collagen: a multicenter, double-masked, randomized, within-subject study. Dermatol Surg. 2007;33(Suppl 2):S128–35.

    CAS  PubMed  Google Scholar 

  25. Pinsky MA, Thomas JA, Murphy DK, Walker PS. Juvederm vs. Zyplast nasolabial fold study G. Juvederm injectable gel: a multicenter, double-blind, randomized study of safety and effectiveness. Aesthet Surg J. 2008;28(1):17–23.

    Article  CAS  PubMed  Google Scholar 

  26. Narins RS, Coleman WP 3rd, Donofrio LM, et al. Nonanimal sourced hyaluronic acid-based dermal filler using a cohesive polydensified matrix technology is superior to bovine collagen in the correction of noderate to severe nasolabial folds: results froma 6-month, randomized, blinded, controlled, multicenter study. Dermatol Surg. 2010;36(51):711–40.

    Google Scholar 

  27. Narins RS, Coleman WP 3rd, Donofrio LM, et al. Improvement in nasolabial folds with a hyaluronic acid filler using a cohesive polydensified matrix technology: results from an 18-month open-label extension trial. Dermatol Surg. 2010;36(Suppl 3):1800–8.

    Article  CAS  PubMed  Google Scholar 

  28. Summary of Safety and Effectiveness Data (SSED). Silver Springs: U.S. Food and Drug Administration; 2017.

    Google Scholar 

  29. Levy PM, De Boulle K, Raspaldo H. Comparison of injection comfort of a new category of cohesive hyaluronic acid filler with preincorporated lidocaine and a hyaluronic acid filler alone. Dermatol Surg. 2009;35(Suppl 1):332–6. discussion 337.

    Article  CAS  PubMed  Google Scholar 

  30. Moers-Carpi M, Storck R, Howell DJ, Ogilvie P, Ogilvie A. Physician and patient satisfaction after use of calcium hydroxylapatite for cheek augmentation. Dermatol Surg. 2012;38(7 Pt 2):1217–22.

    Article  CAS  PubMed  Google Scholar 

  31. Moers-Carpi MM, Tufet JO. Calcium hydroxylapatite versus nonanimal stabilized hyaluronic acid for the correction of nasolabial folds: a 12-month, multicenter, prospective, randomized, controlled, split-face trial. Dermatol Surg. 2008;34(2):210–5.

    Article  CAS  PubMed  Google Scholar 

  32. Marmur ES, Phelps R, Goldberg DJ. Clinical, histologic and electron microscopic findings after injection of a calcium hydroxylapatite filler. J Cosmet Laser Ther. 2004;6(4):223–6.

    Article  PubMed  Google Scholar 

  33. Tzikas TL. A 52-month summary of results using calcium hydroxylapatite for facial soft tissue augmentation. Dermatol Surg. 2008;34(Suppl 1):S9–15.

    CAS  PubMed  Google Scholar 

  34. Carruthers A, Liebeskind M, Carruthers J, Forster BB. Radiographic and computed tomographic studies of calcium hydroxylapatite for treatment of HIV-associated facial lipoatrophy and correction of nasolabial folds. Dermatol Surg. 2008;34(Suppl 1):S78–84.

    CAS  PubMed  Google Scholar 

  35. Brandt FS, Cazzaniga A, Baumann L, et al. Investigator global evaluations of efficacy of injectable poly-L-lactic acid versus human collagen in the correction of nasolabial fold wrinkles. Aesthet Surg J. 2011;31(5):521–8.

    Article  PubMed  Google Scholar 

  36. Brown SA, Rohrich RJ, Baumann L, et al. Subject global evaluation and subject satisfaction using injectable poly-L-lactic acid versus human collagen for the correction of nasolabial fold wrinkles. Plast Reconstr Surg. 2011;127(4):1684–92.

    Article  CAS  PubMed  Google Scholar 

  37. Kane MA, Lorenc ZP, Lin X, Smith SR. Validation of a lip fullness scale for assessment of lip augmentation. Plast Reconstr Surg. 2012;129(5):822e–8e.

    Article  PubMed  CAS  Google Scholar 

  38. Werschler WP, Fagien S, Thomas J, Paradkar-Mitragotri D, Rotunda A, Beddingfield FC 3rd. Development and validation of a photographic scale for assessment of lip fullness. Aesthet Surg J. 2015;35(3):294–307.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Carruthers A, Carruthers J, Hardas B, et al. A validated grading scale for marionette lines. Dermatol Surg. 2008;34(Suppl 2):S167–72.

    CAS  PubMed  Google Scholar 

  40. Narins RS, Carruthers J, Flynn TC, et al. Validated assessment scales for the lower face. Dermatol Surg. 2012;38(2 Spec):333–42.

    Article  CAS  PubMed  Google Scholar 

  41. Cohen JL, Thomas J, Paradkar D, et al. An interrater and intrarater reliability study of 3 photographic scales for the classification of perioral aesthetic features. Dermatol Surg. 2014;40(6):663–70.

    CAS  PubMed  Google Scholar 

  42. Glogau RG, Bank D, Brandt F, et al. A randomized, evaluator-blinded, controlled study of the effectiveness and safety of small gel particle hyaluronic acid for lip augmentation. Dermatol Surg. 2012;38(7 Pt 2):1180–92.

    Article  CAS  PubMed  Google Scholar 

  43. Beer K, Glogau RG, Dover JS, et al. A randomized, evaluator-blinded, controlled study of effectiveness and safety of small particle hyaluronic acid plus lidocaine for lip augmentation and perioral rhytides. Dermatol Surg. 2015;41(Suppl 1):S127–36.

    Article  PubMed  Google Scholar 

  44. Samuelson U, Fagrell D, Wetter A, Kuusk S, Hamilton L, Haglund P. An open-label, multicenter, evaluator-blinded study to assess the efficacy and safety of a new hyaluronic acid-based gel product for lip enhancement. Dermatol Surg. 2015;41(9):1052–9.

    Article  CAS  PubMed  Google Scholar 

  45. Dayan S, Bruce S, Kilmer S, et al. Safety and effectiveness of the hyaluronic acid filler, HYC-24L, for lip and perioral augmentation. Dermatol Surg. 2015;41(Suppl 1):S293–301.

    Article  PubMed  Google Scholar 

  46. Butterwick K, Marmur E, Narurkar V, et al. HYC-24L demonstrates greater effectiveness with less pain than CPM-22.5 for treatment of perioral lines in a randomized controlled trial. Dermatol Surg. 2015;41(12):1351–60.

    Article  CAS  PubMed  Google Scholar 

  47. Black JM, Jones DH. A 6 month study evaluating cohesive polydensified matrix hyaluronic acid filler for the treatment of etched-in fine facial lines. IMCAS World Congress; January 26–29, 2017; Paris, France.

    Google Scholar 

  48. Raspaldo H, Chantrey J, Belhaouari L, Saleh R, Murphy DK. Juvederm volbella with lidocaine for lip and perioral enhancement: a prospective, randomized, controlled trial. Plast Reconstr Surg Glob Open. 2015;3(3):e321.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Eccleston D, Murphy DK. Juvederm((R)) Volbella in the perioral area: a 12-month prospective, multicenter, open-label study. Clin Cosmet Investig Dermatol. 2012;5:167–72.

    PubMed  PubMed Central  Google Scholar 

  50. Administration USFaD. Vobella(R) XC PMA P110033/S018/A003. In: Administration USFaD, editors. Silver Spring: FDA Maryland; 2016.

    Google Scholar 

  51. Artzi O, Loizides C, Verner I, Landau M. Resistant and Recurrent Late Reaction to Hyaluronic Acid-Based Gel. Dermatol Surg. 2016;42(1):31–7.

    Article  CAS  PubMed  Google Scholar 

  52. Beleznay K, Carruthers JD, Carruthers A, Mummert ME, Humphrey S. Delayed-onset nodules secondary to a smooth cohesive 20 mg/ml hyaluronic acid filler: cause and management. Dermatol Surg. 2015;41(8):929–39.

    Article  CAS  PubMed  Google Scholar 

  53. U.S. Food and drug administration. Meeting of the general and plastic surgery devices panel FDA advisory committee briefing document: Juvederm Voluma XC PMA (P110033). Silver Spring: FDA Maryland; 2013.

    Google Scholar 

  54. Sykes JM, Carruthers A, Hardas B, et al. Development and validation of a photonumeric scale for assessment of chin retrusion. Dermatol Surg. 2016;42(Suppl 1):S211–8.

    Article  PubMed  PubMed Central  Google Scholar 

  55. A study of hyaluronic acid injectable gel (VYC-25L) for restoration and creation of facial colume in the chin and jaw. U.S, National Institutes of Health; 2016. https://clinicaltrials.gov/ct2/show/NCT02559908?term=allergan+chin&rank=1. Accessed 7 Jan 2017.

  56. Juvederm Voluma(R) XC for Treatment of Hypoplastic Chin (VolumaChin). U.S. National Institutes of Health; 2015. https://clinicaltrials.gov/ct2/show/NCT02330016?term=voluma&rank=2. Accessed 7 Jan 2017.

  57. Matarasso SL, Carruthers JD, Jewell ML, Restylane Consensus G. Consensus recommendations for soft-tissue augmentation with nonanimal stabilized hyaluronic acid (Restylane). Plast Reconstr Surg. 2006;117(3 Suppl):3S–34S. discussion 35S–43S.

    Article  PubMed  Google Scholar 

  58. Bertossi D, Galzignato PF, Albanese M, Botti C, Botti G, Nocini PF. Chin microgenia: a clinical comparative study. Aesthet Plast Surg. 2015;39(5):651–8.

    Article  Google Scholar 

  59. Fischer TC. A European evaluation of cosmetic treatment of facial volume loss with Juvederm Voluma in patients previously treated with Restylane Sub-Q. J Cosmet Dermatol. 2010;9(4):291–6.

    Article  PubMed  Google Scholar 

  60. Hoffmann K. Juvederm voluma study investigators G. Volumizing effects of a smooth, highly cohesive, viscous 20-mg/ml hyaluronic acid volumizing filler: prospective European study. BMC Dermatol. 2009;9:9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  61. Bae JM, Lee DW. Three-dimensional remodeling of young Asian women’s faces using 20-mg/ml smooth, highly cohesive, viscous hyaluronic acid fillers: a retrospective study of 320 patients. Dermatol Surg. 2013;39(9):1370–5.

    Article  CAS  PubMed  Google Scholar 

  62. Dallara JM, Baspeyras M, Bui P, Cartier H, Charavel MH, Dumas L. Calcium hydroxylapatite for jawline rejuvenation: consensus recommendations. J Cosmet Dermatol. 2014;13(1):3–14.

    Article  PubMed  Google Scholar 

  63. Jansen DA, Graivier MH. Evaluation of a calcium hydroxylapatite-based implant (Radiesse) for facial soft-tissue augmentation. Plast Reconstr Surg. 2006;118(3 Suppl):22S–30S. discussion 31S–33S.

    Article  CAS  PubMed  Google Scholar 

  64. Sarnoff DS, Gotkin RH. ACELIFT: a minimally invasive alternative to a facelift. J Drugs Dermatol. 2014;13(9):1038–46.

    PubMed  Google Scholar 

  65. Lorenc ZP. Techniques for the optimization of facial and nonfacial volumization with injectable poly-L-lactic acid. Aesthet Plast Surg. 2012;36(5):1222–9.

    Article  Google Scholar 

  66. Vleggaar D. Facial volumetric correction with injectable poly-L-lactic acid. Dermatol Surg. 2005;31(11 Pt 2):1511–7. discussion 1517–1518.

    Article  CAS  PubMed  Google Scholar 

  67. Knapp TR, Vistnes LM. The augmentation of soft tissue with injectable collagen. Clin Plast Surg. 1985;12(2):221–5.

    Article  CAS  PubMed  Google Scholar 

  68. Webster RC, Hamdan US, Gaunt JM, Fuleihan NS, Smith RC. Rhinoplastic revisions with injectable silicone. Arch Otolaryngol Head Neck Surg. 1986;112(3):269–76.

    Article  CAS  PubMed  Google Scholar 

  69. Han SK, Shin SH, Kang HJ, Kim WK. Augmentation rhinoplasty using injectable tissue-engineered soft tissue: a pilot study. Ann Plast Surg. 2006;56(3):251–5.

    Article  CAS  PubMed  Google Scholar 

  70. Becker H. Nasal augmentation with calcium hydroxylapatite in a carrier-based gel. Plast Reconstr Surg. 2008;121(6):2142–7.

    Article  CAS  PubMed  Google Scholar 

  71. Rokhsar C, Ciocon DH. Nonsurgical rhinoplasty: an evaluation of injectable calcium hydroxylapatite filler for nasal contouring. Dermatol Surg. 2008;34(7):944–6.

    CAS  PubMed  Google Scholar 

  72. de Lacerda DA, Zancanaro P. Filler rhinoplasty. Dermatol Surg. 2007;33(Suppl 2):S207–12. discussion S212.

    PubMed  Google Scholar 

  73. Cassuto D. The use of Dermicol-P35 dermal filler for nonsurgical rhinoplasty. Aesthet Surg J. 2009;29(3 Suppl):S22–4.

    Article  PubMed  Google Scholar 

  74. Siclovan HR, Jomah JA. Injectable calcium hydroxylapatite for correction of nasal bridge deformities. Aesthet Plast Surg. 2009;33(4):544–8.

    Article  Google Scholar 

  75. Rivkin A, Soliemanzadeh P. Nonsurgical injection rhinoplasty with calcium hydroyxlapatite in a carrier gel (radiesse): a 4-year retrospective, clinical review. Cosmet Dermatol. 2009;22(12):619–24.

    Google Scholar 

  76. Bray D, Hopkins C, Roberts DN. Injection rhinoplasty: non-surgical nasal augmentation and correction of post-rhinoplasty contour asymmetries with hyaluronic acid: how we do it. Clin Otolaryngol. 2010;35(3):227–30.

    Article  CAS  PubMed  Google Scholar 

  77. Dayan SH, Kempiners JJ. Treatment of the lower third of the nose and dynamic nasal tip ptosis with Botox. Plast Reconstr Surg. 2005;115(6):1784–5.

    Article  CAS  PubMed  Google Scholar 

  78. Monreal J. Fat grafting to the nose: personal experience with 36 patients. Aesthet Plast Surg. 2011;35(5):916–22.

    Article  Google Scholar 

  79. Kim P, Ahn JT. Structured nonsurgical Asian rhinoplasty. Aesthet Plast Surg. 2012;36(3):698–703.

    Article  Google Scholar 

  80. Juvederm Voluma(R) to ehance the appearance of Asian nose. U.S. National Institutes of Health; 2015. https://clinicaltrials.gov/ct2/show/NCT01846039?term=voluma+nose&rank=1. Accessed 7 Jan 2016.

  81. Restylane Perlane to shape the nasal dorsum and/or nasal root. U.S. National Institutes of Health; 2016. https://clinicaltrials.gov/ct2/show/NCT02216851?term=hyaluronic+acid+nose&rank=3. Accessed 7 Jan 2016.

  82. Han X, Hu J, Cheng L, Li F. Multiplane hyaluronic acid (EME) in female Chinese rhinoplasty using blunt and sharp needle technique. J Plast Reconstr Aesthet Surg. 2015;68(11):1504–9.

    Article  PubMed  Google Scholar 

  83. Redaelli A. Medical rhinoplasty with hyaluronic acid and botulinum toxin A: a very simple and quite effective technique. J Cosmet Dermatol. 2008;7(3):210–20.

    Article  PubMed  Google Scholar 

  84. Park SW, Woo SJ, Park KH, Huh JW, Jung C, Kwon OK. Iatrogenic retinal artery occlusion caused by cosmetic facial filler injections. Am J Ophthalmol. 2012;154(4):653–62. e651.

    Article  PubMed  Google Scholar 

  85. Stupak HD, Moulthrop TH, Wheatley P, Tauman AV, Johnson CM Jr. Calcium hydroxylapatite gel (Radiesse) injection for the correction of postrhinoplasty contour deficiencies and asymmetries. Arch Facial Plast Surg. 2007;9(2):130–6.

    Article  PubMed  Google Scholar 

  86. Kurkjian TJ, Ahmad J, Rohrich RJ. Soft-tissue fillers in rhinoplasty. Plast Reconstr Surg. 2014;133(2):121e–6e.

    Article  CAS  PubMed  Google Scholar 

  87. Schuster B. Injection rhinoplasty with hyaluronic acid and calcium hydroxyapatite: a retrospective survey investigating outcome and complication rates. Facial Plast Surg. 2015;31(3):301–7.

    Article  CAS  PubMed  Google Scholar 

  88. Solomon P, Sklar M, Zener R. Facial soft tissue augmentation with Artecoll((R)): A review of eight years of clinical experience in 153 patients. Can J Plast Surg. 2012;20(1):28–32.

    Article  PubMed  PubMed Central  Google Scholar 

  89. Chen L, Li SR, Yu P, Wang ZX. Comparison of artecoll, restylane and silicone for augmentation rhinoplasty in 378 Chinese patients. Clin Invest Med. 2014;37(4):E203–10.

    Article  PubMed  Google Scholar 

  90. Jones D, Carruthers A, Hardas B, et al. Development and validation of a photonumeric scale for evaluation of transverse neck lines. Dermatol Surg. 2016;42(Suppl 1):S235–42.

    Article  PubMed  PubMed Central  Google Scholar 

  91. Chao YY, Chiu HH, Howell DJ. A novel injection technique for horizontal neck lines correction using calcium hydroxylapatite. Dermatol Surg. 2011;37(10):1542–5.

    Article  CAS  PubMed  Google Scholar 

  92. Lowe NJ, Grover R. Injectable hyaluronic acid implant for malar and mental enhancement. Dermatol Surg. 2006;32(7):881–5. discussion 885.

    CAS  PubMed  Google Scholar 

  93. Mazzuco R, Hexsel D. Poly-L-lactic acid for neck and chest rejuvenation. Dermatol Surg. 2009;35(8):1228–37.

    Article  CAS  PubMed  Google Scholar 

  94. Fabi SG, Burgess C, Carruthers A, et al. Consensus recommendations for combined aesthetic interventions using botulinum toxin, fillers, and microfocused ultrasound in the neck, decolletage, hands, and other areas of the body. Dermatol Surg. 2016;42(10):1199–208.

    Article  CAS  PubMed  Google Scholar 

  95. Fabi SG, Goldman MP, Mills DC, et al. Combining microfocused ultrasound with botulinum toxin and temporary and semi-permanent dermal fillers: safety and current use. Dermatol Surg. 2016;42(Suppl 2):S168–76.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Director of Dermatology, Aesthetx Plastic Surgery and Dermatology, Campbell, CA, USA

    Amelia K. Hausauer

  2. Skin Care and Laser Physicians of Beverly Hills, Los Angeles, CA, USA

    Derek H. Jones

  3. Division of Dermatology, University of California, Los Angeles, CA, USA

    Derek H. Jones

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Correspondence to Amelia K. Hausauer .

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Editors and Affiliations

  1. Department of Dermatology, Northwestern University, Chicago, IL, USA

    Murad Alam

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Hausauer, A.K., Jones, D.H. (2019). Soft Tissue Augmentation (Temporary Injectable Fillers) of the Lower Face and Neck (Lips, Perioral, Nose, Neck). In: Alam, M. (eds) Evidence-Based Procedural Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-030-02023-1_39

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