Abstract
This chapter provides a broad overview of the applications of nanotechnology in cancer medicine. The fundamental physics and chemistry of different classes of nanoparticles are first described to detail the origin of their useful emergent properties in the context of current needs in cancer medicine and standard clinical practices. Specific applications focus on cancer therapeutics, cancer imaging, and in vitro diagnostics. In particular, this chapter describes how nanocrystals exhibit unique and tunable interactions with light and magnetic fields that provide new means to both detect and manipulate tumor tissue. The tunable physical structures of nanomaterials also lead to unique interactions with biomolecules, cells, and tissues that have been instrumental in precisely controlling how drugs distribute in the body and localize to solid tumors. Emphasis is given to the potential benefits of theranostic materials that pair therapeutic and diagnostic capabilities to predict and monitor the progress of therapy.
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References
Whitesides, G.M.: Nanoscience, nanotechnology, and chemistry. Small. 1, 172–179 (2005)
Sarikaya, M., Tamerler, C., Jen, A.K.Y., et al.: Molecular biomimetics: nanotechnology through biology. Nat. Mater. 2, 577–585 (2003)
Wong, I.Y., Bhatia, S.N., Toner, M.: Nanotechnology: emerging tools for biology and medicine. Genes Dev. 27, 2397–2408 (2013)
Nie, S.M., Xing, Y., Kim, G.J., et al.: Nanotechnology applications in cancer. Annu. Rev. Biomed. Eng. 9, 257–288 (2007)
Heath, J.R., Davis, M.E.: Nanotechnology and cancer. Annu. Rev. Med. 59, 251–265 (2008)
Rose, P.G.: Pegylated liposomal doxorubicin: optimizing the dosing schedule in ovarian cancer. Oncologist. 10, 205–214 (2005)
Wang-Gillam, A., Li, C.P., Bodoky, G., et al.: Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial. Lancet. 387, 545–557 (2016)
Evers P (2015) Nanotechnology in medical applications: The Global Market. BCC Research
Theek, B., Rizzo, L.Y., Ehling, J., et al.: The theranostic path to personalized nanomedicine. Clin. Transl. Imag. 2, 67–76 (2014)
Fornaguera, C., Garcia-Celma, M.J.: Personalized nanomedicine: a revolution at the nanoscale. J. Pers. Med. 7, 12 (2017)
Kobeissy, F.H., Gulbakan, B., Alawieh, A., et al.: Post-Genomics Nanotechnology Is Gaining Momentum: Nanoproteomics and Applications in Life Sciences. OMICS. 18, 111–131 (2014)
Pelaz, B., Charron, G., Pfeiffer, C., et al.: Interfacing engineered nanoparticles with biological systems: anticipating adverse nanoBio interactions. Small. 9, 1573–1584 (2013)
Albanese, A., Tang, P.S., Chan, W.C.W.: The effect of nanoparticle size, shape, and surface chemistry on biological systems. Annu. Rev. Biomed. Eng. 14, 1–16 (2012)
Owens 3rd, D.E., Peppas, N.A.: Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int. J. Pharm. 307, 93–102 (2006)
Bazak, R., Houri, M., El Achy, S., et al.: Cancer active targeting by nanoparticles: a comprehensive review of literature. J. Cancer Res. Clin. Oncol. 141, 769–784 (2015)
Blanco, E., Shen, H., Ferrari, M.: Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat. Biotech. 33, 941–951 (2015)
Kim, J., Piao, Y., Hyeon, T.: Multifunctional nanostructured materials for multimodal imaging, and simultaneous imaging and therapy. Chem. Soc. Rev. 38, 372–390 (2009)
Eustis, S., El-Sayed, M.A.: Why gold nanoparticles are more precious than pretty gold: Noble metal surface plasmon resonance and its enhancement of the radiative and nonradiative properties of nanocrystals of different shapes. Chem. Soc. Rev. 35, 209–217 (2006)
Jain, P.K., Huang, X., El-Sayed, I.H., et al.: Review of some interesting surface plasmon resonance-enhanced properties of noble metal nanoparticles and their applications to biosystems. Plasmonics. 2, 107–118 (2007)
Abadeer, N.S., Murphy, C.J.: Recent progress in cancer thermal therapy using gold nanoparticles. J. Phys. Chem. C. 120, 4691–4716 (2016)
Anselmo, A.C., Mitragotri, S.: Nanoparticles in the clinic. Bioeng. Transl. Med. 1, 10–29 (2016)
Smith, A.M., Nie, S.M.: Semiconductor nanocrystals: structure, properties, and bandgap engineering. Acc. Chem. Res. 43, 190–200 (2010)
Juzenas, P., Chen, W., Sun, Y.P., et al.: Quantum dots and nanoparticles for photodynamic and radiation therapies of cancer. Adv. Drug Deliv. Rev. 60, 1600–1614 (2008)
Gao, J., Gu, H., Xu, B.: Multifunctional magnetic nanoparticles: design, synthesis, and biomedical applications. Acc. Chem. Res. 42, 1097–1107 (2009)
Haun, J.B., Yoon, T.-J., Lee, H., et al.: Magnetic nanoparticle biosensors. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 2, 291–304 (2010)
Singh, A., Sahoo, S.K.: Magnetic nanoparticles: a novel platform for cancer theranostics. Drug Discov. Today. 19, 474–481 (2014)
Peer, D., Karp, J.M., Hong, S., et al.: Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotech. 2, 751–760 (2007)
Israelachvili, J.N.: Intermolecular and surface forces, 3rd edn. Academic Press, Boston, MA (2011)
Georgakilas, V., Perman, J.A., Tucek, J., et al.: Broad family of carbon nanoallotropes: classification, chemistry, and applications of fullerenes, carbon dots, nanotubes, graphene, nanodiamonds, and combined superstructures. Chem. Rev. 115, 4744–4822 (2015)
Li, S.-D., Huang, L.: Pharmacokinetics and biodistribution of nanoparticles. Mol. Pharm. 5, 496–504 (2008)
Florence, A.T.: The oral absorption of micro- and nanoparticulates: Neither exceptional nor unusual. Pharm. Res. 14, 259–266 (1997)
Jain, R.K., Stylianopoulos, T.: Delivering nanomedicine to solid tumors. Nat. Rev. Clin. Oncol. 7, 653–664 (2010)
Komarova, Y., Malik, A.B.: Regulation of endothelial permeability via paracellular and transcellular transport pathways. Annu. Rev. Physiol. 72, 463–493 (2010)
Chauhan, V.P., Stylianopoulos, T., Boucher, Y., et al.: Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies. Annu. Rev. Chem. Biomol. Eng. 2, 281–298 (2011)
Kievit, F.M., Zhang, M.: Cancer nanotheranostics: improving imaging and therapy by targeted delivery across biological barriers. Adv. Mater. 23, H217–H247 (2011)
Toutain, P.L., Bousquet-Melou, A.: Plasma clearance. J. Vet. Pharmacol. Ther. 27, 415–425 (2004)
Moeller, M.J., Tenten, V.: Renal albumin filtration: alternative models to the standard physical barriers. Nat. Rev. Neph. 9, 266–277 (2013)
Sorensen, K.K., Simon-Santamaria, J., McCuskey, R.S., et al.: Liver Sinusoidal Endothelial Cells. Compr. Physiol. 5, 1751–1774 (2015)
Zhang, Y.N., Poon, W., Tavares, A.J., et al.: Nanoparticle-liver interactions: cellular uptake and hepatobiliary elimination. J. Control. Release. 240, 332–348 (2016)
Goel, S., Duda, D.G., Xu, L., et al.: Normalization of the vasculature for treatment of cancer and other diseases. Physiol. Rev. 91, 1071–1121 (2011)
Allen, T.M., Cullis, P.R.: Drug delivery systems: Entering the mainstream. Science. 303, 1818–1822 (2004)
Fang, J., Nakamura, H., Maeda, H.: The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv. Drug Deliv. Rev. 63, 136–151 (2011)
Wilhelm, S., Tavares, A.J., Dai, Q., et al.: Analysis of nanoparticle delivery to tumours. Nat. Rev. Mater. 1, 16014 (2016)
Jain, R.K.: Transport of molecules in the tumor interstitium: a review. Cancer Res. 47, 3039–3051 (1987)
Chinen, A.B., Guan, C.M., Ferrer, J.R., et al.: Nanoparticle probes for the detection of cancer biomarkers, cells, and tissues by fluorescence. Chem. Rev. 115, 10530–10574 (2015)
Chauhan, V.P., Jain, R.K.: Strategies for advancing cancer nanomedicine. Nat. Mater. 12, 958–962 (2013)
Chrastina, A., Massey, K.A., Schnitzer, J.E.: Overcoming in vivo barriers to targeted nanodelivery. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 3, 421–437 (2011)
Oh, P., Testa, J.E., Borgstrom, P., et al.: In vivo proteomic imaging analysis of caveolae reveals pumping system to penetrate solid tumors. Nat. Med. 20, 1062–1068 (2014)
Xu, X., Ho, W., Zhang, X., et al.: Cancer nanomedicine: from targeted delivery to combination therapy. Trends Mol. Med. 21, 223–232 (2015)
Duncan, R.: Polymer conjugates as anticancer nanomedicines. Nat. Rev. Cancer. 6, 688–701 (2006)
Alexis, F., Pridgen, E., Molnar, L.K., et al.: Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol. Pharm. 5, 505–515 (2008)
Ma, L., Kohli, M., Smith, A.: Nanoparticles for combination drug therapy. ACS Nano. 7, 9518–9525 (2013)
Feldman, E.J., Lancet, J.E., Kolitz, J.E., et al.: First-in-man study of CPX-351: a liposomal carrier containing cytarabine and daunorubicin in a fixed 5:1 molar ratio for the treatment of relapsed and refractory acute myeloid leukemia. J. Clin. Oncol. 29, 979–985 (2011)
Chatterjee, D.K., Fong, L.S., Zhang, Y.: Nanoparticles in photodynamic therapy: An emerging paradigm. Adv. Drug Deliv. Rev. 60, 1627–1637 (2008)
Fitzpatrick, J.A.J., Andreko, S., Ernst, L.A., et al.: Long-term persistence and spectral blue shifting of quantum dots in vivo. Nano Lett. 9, 2736–2741 (2009)
Tran, S., DeGiovanni, P.J., Piel, B., et al.: Cancer nanomedicine: a review of recent success in drug delivery. Clin. Transl. Med. 6, 44 (2017)
Senzer, N., Nemunaitis, J., Nemunaitis, D., et al.: Phase I study of a systemically delivered p53 nanoparticle in advanced solid tumors. Mol. Ther. 21, 1096–1103 (2013)
Granot, Y., Peer, D.: Delivering the right message: challenges and opportunities in lipid nanoparticles-mediated modified mRNA therapeutics-An innate immune system standpoint. Semin. Immunol. 34, 68–77 (2017)
Jiang, W., Huang, Y., An, Y., et al.: Remodeling tumor vasculature to enhance delivery of intermediate-sized nanoparticles. ACS Nano. 9, 8689–8696 (2015)
Park, J.W., Kirpotin, D.B., Hong, K., et al.: Tumor targeting using anti-her2 immunoliposomes. J. Control. Release. 74, 95–113 (2001)
Tirkes, T., Hollar, M.A., Tann, M., et al.: Response criteria in oncologic imaging: review of traditional and new criteria. Radiographics. 33, 1323–1341 (2013)
Frangioni, J.V.: New technologies for human cancer imaging. J. Clin. Oncol. 26, 4012–4021 (2008)
Key, J., Leary, J.F.: Nanoparticles for multimodal in vivo imaging in nanomedicine. Int. J. Nanomedicine. 9, 711–726 (2014)
Maenosono, S., Suzuki, T., Saita, S.: Superparamagnetic FePt nanoparticles as excellent MRI contrast agents. J. Magn. Magn. Mater. 320, L79–L83 (2008)
O'Farrell, A.C., Shnyder, S.D., Marston, G., et al.: Non-invasive molecular imaging for preclinical cancer therapeutic development. Br. J. Pharmacol. 169, 719–735 (2013)
Dobrucki, L.W., Pan, D.J., Smith, A.M.: Multiscale imaging of nanoparticle drug delivery. Curr. Drug Targets. 16, 560–570 (2015)
de Barros, A.L.B., Tsourkas, A., Saboury, B., et al.: Emerging role of radiolabeled nanoparticles as an effective diagnostic technique. EJNMMI Res. 2, 39 (2012)
Guerrero, S., Herance, J.R., Rojas, S., et al.: Synthesis and in vivo evaluation of the biodistribution of a 18F-labeled conjugate gold-nanoparticle-peptide with potential biomedical application. Bioconjug. Chem. 23, 399–408 (2012)
Wang, Y., Li, X., Zhou, Y., et al.: Preparation of nanobubbles for ultrasound imaging and intracellular drug delivery. Int. J. Pharm. 384, 148–153 (2010)
Singhal, S., Nie, S.M., Wang, M.D.: Nanotechnology applications in surgical oncology. Annu. Rev. Med. 61, 359–373 (2010)
Kaufmann, B.A., Lindner, J.R.: Molecular imaging with targeted contrast ultrasound. Curr. Opin. Biotechnol. 18, 11–16 (2007)
Vahrmeijer, A.L., Hutteman, M., van der Vorst, J.R., et al.: Image-guided cancer surgery using near-infrared fluorescence. Nat. Rev. Clin. Oncol. 10, 507–518 (2013)
Orbay, H., Bean, J., Zhang, Y., et al.: Intraoperative targeted optical imaging: a guide towards tumor-free margins in cancer surgery. Curr. Pharm. Biotechnol. 14, 733–742 (2014)
Chi, C., Du, Y., Ye, J., et al.: Intraoperative imaging-guided cancer surgery: from current fluorescence molecular imaging methods to future multi-modality imaging technology. Theranostics. 4, 1072–1084 (2014)
Sivasubramanian, M., Hsia, Y., Lo, L.W.: Nanoparticle-facilitated functional and molecular imaging for the early detection of cancer. Front. Mol. Biosci. 1, 15 (2014)
Huang, X., El-Sayed, M.A.: Gold nanoparticles: optical properties and implementations in cancer diagnosis and photothermal therapy. J. Adv. Res. 1, 13–28 (2010)
Meads, C., Auguste, P., Davenport, C., et al.: Positron emission tomography/computerised tomography imaging in detecting and managing recurrent cervical cancer: systematic review of evidence, elicitation of subjective probabilities and economic modelling. Health Technol. Assess. 17, 1–323 (2013)
Ravizzini, G., Turkbey, B., Barrett, T., et al.: Nanoparticles in sentinel lymph node mapping. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 1, 610–623 (2009)
Phillips, E., Penate-Medina, O., Zanzonico, P.B., et al.: Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe. Sci. Transl. Med. 6, 260ra149 (2014)
Morton, J.G., Day, E.S., Halas, N.J., et al.: Nanoshells for photothermal cancer therapy. Methods Mol. Biol. 624, 101–117 (2010)
Tan, Y.F., Chandrasekharan, P., Maity, D., et al.: Multimodal tumor imaging by iron oxides and quantum dots formulated in poly (lactic acid)-D-alpha-tocopheryl polyethylene glycol 1000 succinate nanoparticles. Biomaterials. 32, 2969–2978 (2011)
Xie, J., Chen, K., Huang, J., et al.: PET/NIRF/MRI triple functional iron oxide nanoparticles. Biomaterials. 31, 3016–3022 (2010)
Grandhi, T.S., Rege, K.: Design, synthesis, and functionalization of nanomaterials for therapeutic drug delivery. Adv. Exp. Med. Biol. 811, 157–182 (2014)
Dobrucki, L.W., Sinusas, A.J.: PET and SPECT in cardiovascular molecular imaging. Nat. Rev. Cardiol. 7, 38–47 (2010)
Dobrucki, L.W., de Muinck, E.D., Lindner, J.R., et al.: Approaches to Multimodality Imaging of Angiogenesis. J. Nucl. Med. 51(Suppl 1), 66S–79S (2010)
Tang, L., Yang, X., Yin, Q., et al.: Investigating the optimal size of anticancer nanomedicine. Proc. Natl. Acad. Sci. U. S. A. 111, 15344–15349 (2014)
Siravegna, G., Marsoni, S., Siena, S., et al.: Integrating liquid biopsies into the management of cancer. Nat. Rev. Clin. Oncol. 14, 531–548 (2017)
Crowley, E., Di Nicolantonio, F., Loupakis, F., et al.: Liquid biopsy: monitoring cancer-genetics in the blood. Nat. Rev. Clin. Oncol. 10, 472–484 (2013)
Elghanian, R., Storhoff, J.J., Mucic, R.C., et al.: Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles. Science. 277, 1078–1081 (1997)
Lee, H., Sun, E., Ham, D., et al.: Chip-NMR biosensor for detection and molecular analysis of cells. Nat. Med. 14, 869–874 (2008)
Blanco-Canosa, J.B., Wu, M., Susumu, K., et al.: Recent progress in the bioconjugation of quantum dots. Coord. Chem. Rev. 263, 101–137 (2014)
Zhou, K., Wang, Y., Huang, X., et al.: Tunable, ultrasensitive pH-responsive nanoparticles targeting specific endocytic organelles in living cells. Angew. Chem. Int. Ed. 50, 6109–6114 (2011)
Nguyen, H.H., Park, J., Kang, S., et al.: Surface plasmon resonance: a versatile technique for biosensor applications. Sensors. 15, 10481–10510 (2015)
Cunningham, B.T., Zangar, R.C.: Photonic crystal enhanced fluorescence for early breast cancer biomarker detection. J. Biophotonics. 5(8–9), 617–628 (2012)
Bhattacharya, S., Jang, J., Yang, L., et al.: BioMEMS and nanotechnology-based approaches for rapid detection of biological entities. J. Rapid Meth. Automat. Microbiol. 15, 1–32 (2007)
Das, J., Ivanov, I., Montermini, L., et al.: An electrochemical clamp assay for direct, rapid analysis of circulating nucleic acids in serum. Nat. Chem. 7, 569–575 (2015)
Zhang, W., Hubbard, A., Brunhoeber, P., et al.: Automated multiplexing quantum dots in situ hybridization assay for simultaneous detection of ERG and PTEN gene status in prostate cancer. J. Mol. Diagn. 15, 754–764 (2013)
Smith, A.M., Dave, S., Nie, S.M., et al.: Multicolor quantum dots for molecular diagnostics of cancer. Expert. Rev. Mol. Diagn. 6, 231–244 (2006)
Nam, J.M., Thaxton, C.S., Mirkin, C.A.: Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins. Science. 301, 1884–1886 (2003)
Jain, K.K.: Nanotechnology in clinical laboratory diagnostics. Clin. Chim. Acta. 358, 37–54 (2005)
Xie, J., Lee, S., Chen, X.: Nanoparticle-based theranostic agents. Adv. Drug Deliv. Rev. 62, 1064–1079 (2010)
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Ma, L., Le, P., Kohli, M., Smith, A.M. (2019). Nanomedicine in Cancer. In: Rai, P., Morris, S.A. (eds) Nanotheranostics for Cancer Applications. Bioanalysis, vol 5. Springer, Cham. https://doi.org/10.1007/978-3-030-01775-0_4
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