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Cancer Diagnostics and Therapeutics

  • Uma Prabhakar
  • Yalia Jayalakshmi
  • C. Katherine Wang
Chapter
Part of the Bioanalysis book series (BIOANALYSIS, volume 5)

Abstract

Cancer is the second most common cause of death in the USA exceeded only by heart disease. Over the past several decades, novel targets and innovative approaches have been initiated and developed resulting in the approval of a significant number of new drugs for the treatment of various cancers and better and improved treatment options, leading to longer survival and better quality of life for the large number of patients diagnosed with the disease each year. In addition to novel and better treatment advances, strides in cancer prevention, together with diagnostics and companion diagnostics development, as well as state-of-the-art personalized medicine approaches to stratify patients more likely to benefit from specific treatment, have contributed to the fight against cancer. In this chapter, clinical advances in diagnostics and therapeutics that have impacted cancer treatment and care will be discussed. Further, the future approaches and strategies including improvements in diagnosis, treatment, and drug delivery that will continue to impact the development of this field are explored while highlighting the opportunities and challenges associated with novel approaches and platforms for both diagnostics and therapeutics.

Keywords

Cancer therapeutics Cancer diagnostics Companion diagnostics Biomarkers Cancer detection Diagnostic imaging Imaging modalities Molecular imaging Liquid biopsy Genetic sequencing Machine learning Cancer treatment approaches Chemotherapeutics Radiation therapy Targeted therapies Immunotherapies Monoclonal antibodies Immune checkpoint inhibitors Cancer vaccines CAR-T Gene therapy Stem cell transplantation Nanoparticles Drug delivery approaches FDA 

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Copyright information

© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019

Authors and Affiliations

  • Uma Prabhakar
    • 1
  • Yalia Jayalakshmi
    • 2
  • C. Katherine Wang
    • 3
  1. 1.Formerly of Office of Cancer Nanotechnology Research, NCIBethesdaUSA
  2. 2.C2CBio ConsultingSunnyvaleUSA
  3. 3.Formerly of BRIM BiotechnologyTaipeiTaiwan

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