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Image-Guided Drug Delivery

  • Camila Gadens Zamboni
  • Keyvan Farahani
  • Jordan J. GreenEmail author
Chapter
Part of the Bioanalysis book series (BIOANALYSIS, volume 5)

Abstract

From intraoperative guidance to remote drug release, the term image-guided drug delivery (IGDD) broadly refers to the utilization of imaging techniques to facilitate drug therapy. With the emerging advances in nanotechnology, the concept of IGDD has increasingly become associated with co-delivery of therapeutic and diagnostic elements incorporated into nanoscale carriers. These carriers, named theranostic nanoplatforms, are of special interest in the oncology field and have been studied in a broad range of applications, such as evaluation of therapeutic response, assessment of pharmacokinetics and biodistribution, and remote control of drug release. IGDD is also considered a promising technology for precision medicine, with the potential to promote individualized diagnosis and therapy for cancer patients on the basis of biomarker’s expression. The suitability of a nanoplatform for an application drives the engineering decisions behind the carrier’s characteristics, signaling agent and matching imaging modality. Herein, IGDD is discussed in the context of preclinical and clinical applications of theranostic nanoplatforms, highlighting molecular imaging modalities and cancer targeting strategies. In this chapter we also describe broader IGDD applications beyond the use of theranostic systems.

Keywords

Image-guided drug delivery Drug delivery Drug carriers Drug delivery systems Drug targeting Active targeting Biochemical markers Passive targeting Nanomedicine Theranostic nanomedicine Theranostics Nanoparticles Molecular imaging Magnetic resonance imaging Radionuclide imaging Optical imaging Ultrasonography Multimodal imaging Biodistribution Controlled release Monitoring therapeutic response Treatment efficacy Image-guided surgery Biomedical research Animal research Clinical trials Clinical efficacy Gene therapy Liposomes Polymer Cancer 

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Copyright information

© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019

Authors and Affiliations

  • Camila Gadens Zamboni
    • 1
  • Keyvan Farahani
    • 2
  • Jordan J. Green
    • 1
    Email author
  1. 1.Department of Biomedical EngineeringTranslational Tissue Engineering Center, Johns Hopkins University School of MedicineBaltimoreUSA
  2. 2.National Cancer Institute, National Institutes of HealthRockvilleUSA

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