Automated Quantification of Blood Flow Velocity from Time-Resolved CT Angiography

  • Pieter Thomas BoonenEmail author
  • Nico Buls
  • Gert Van Gompel
  • Yannick De Brucker
  • Dimitri Aerden
  • Johan De Mey
  • Jef Vandemeulebroucke
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 11043)


Contrast-enhanced computed tomography angiography (CE-CTA) provides valuable, non-invasive assessment of lower extremity peripheral arterial disease (PAD). The advent of wide beam CT scanners has enabled multiple CT acquisitions over the same structure at a high frame rate, facilitating time-resolved CTA acquisitions. In this study, we investigate the technical feasibility of automatically quantifying the bolus arrival time and blood velocity in the arteries below the knee from time-resolved CTA. Our approach is based on arterial segmentation and local estimation of the bolus arrival time. The results are compared to values obtained through manual reading of the datasets and show good agreement. Based on a small patient study, we explore initial utility of these quantitative measures for the diagnosis of lower extremity PAD.


Peripheral arterial disease Time-resolved CTA Blood velocity Lower extremities Artery segmentation 


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Pieter Thomas Boonen
    • 1
    • 2
    • 3
    Email author
  • Nico Buls
    • 2
  • Gert Van Gompel
    • 2
  • Yannick De Brucker
    • 2
  • Dimitri Aerden
    • 4
  • Johan De Mey
    • 2
  • Jef Vandemeulebroucke
    • 1
    • 3
  1. 1.Department of Electronics and Informatics (ETRO)Vrije Universiteit Brussel (VUB)BrusselsBelgium
  2. 2.Department of RadiologyVrije Universiteit Brussel (VUB)BrusselsBelgium
  3. 3.imecLeuvenBelgium
  4. 4.Department of Vascular SurgeryVrije Universiteit Brussel (VUB)BrusselsBelgium

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