Squamous Cell-Lined Esophagus and Hypopharynx: Mucosal Neoplasias

  • Tsuneo OyamaEmail author


For malignant intramucosal or slightly submucosa-invasive early neoplasias of the squamous epithelium in the esophagus and hypopharynx, endoscopic en bloc resection with free margins results in near 100% rate of cure. When the carcinoma is deeply invasive (>200 μm) into the submucosa, the risk of nodal metastasis is too high and resective surgery is indicated. The decision between endoscopic resection and surgical esophagectomy rests on accurate endoscopic diagnosis; biopsy (only one or two) must be targeted to avoid extensive scarring before endoscopic submucosal dissection (ESD). The aim of this chapter is to improve the detection of small and even minute mucosal premalignant or malignant neoplasias, as well as the endoscopic assessment of the lateral extension of the neoplasia and probability and grade of its submucosal invasion.


Esophagus Hypopharynx Squamous epithelium Endoscopic diagnosis Intrapapillary capillary pattern Squamous cell carcinoma  Endoscopic T-staging Endoscopic en-bloc resection 



We acknowledge the contribution of cases by Dr. Hans-Peter Allgaier, Freiburg, Germany; Dr. Gerhard Kleber, Aalen, Germany; and Dr. Daniel Neureiter and Dr. Frieder Berr, Salzburg, Austria.


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Copyright information

© Springer International Publishing 2019

Authors and Affiliations

  1. 1.Department of Endoscopy, Saku Central Hospital Advanced Care CenterSakuJapan

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