Abstract
Endoscopic detection and analysis has set the stage for endoscopic cure of early cancers of the gastrointestinal tract. Endoscopic submucosal dissection (ESD) introduced the principle of oncosurgical en-bloc resection to mucosal neoplasms, providing histological grading, pT staging, and resection R status. ESD aims for curative resection of mucosal cancer. The risk of local recurrence—in the range of 10–35% with snare ablation in piecemeal fashion—is reduced close to zero after curative ESD. Accurate endoscopic analysis of early neoplasias is necessary to decide the differential indication for snare resection, ESD, or surgical resection. ESD is now spreading in Western countries, but requires a twofold learning curve: endo-diagnostic for correct indications and endo-electrosurgical for curative tumor resection.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Kuwano H, et al. Guidelines for diagnosis and treatment of carcinoma of the esophagus April 2012 edited by the Japan Esophageal Society. Esophagus. 2015;12:1–30.
Ono H, et al. Guidelines for endoscopic submucosal dissection and endoscopic mucosal resection for early gastric cancer. Dig Endosc. 2016;28:3–15.
Oyama T, et al. Endoscopic submucosal dissection of early esophageal cancer. Clin Gastroenterol Hepatol. 2005;3:S67–70.
Tanaka S, et al. JGES guidelines for colorectal endoscopic submucosal dissection/endoscopic mucosal resection. Dig Endosc. 2015;27:417–34.
Fuccio L, et al. Clinical outcomes after endoscopic submucosal dissection for colorectal neoplasia: a systematic review and meta-analysis. Gastrointest Endosc. 2017;86:74–86. e17.
Oyama T, et al. How to establish endoscopic submucosal dissection in Western countries. World J Gastroenterol. 2015;21:11209–20.
Pech O, et al. Long-term efficacy and safety of endoscopic resection for patients with mucosal adenocarcinoma of the esophagus. Gastroenterology. 2014;146:652–60.
Tanaka S, et al. Endoscopic submucosal dissection for colorectal neoplasia: possibility of standardization. Gastrointest Endosc. 2007;66:100–7.
Toyonaga T. Endoscopic submucosal dissection using the Flush knife and Flush knife BT. Tech Gastrointest Endosc. 2011;13:84–90.
Yahagi N, et al. Endoscopic submucosal dissection using the flex and the dual knives. Tech Gastrointest Endosc. 2011;13:74–8.
Lee EY, et al. EMR should be the first-line treatment for large laterally spreading colorectal lesions. Gastrointest Endosc. 2016;84:326–8.
Watanabe K, et al. Clinical outcomes of EMR for gastric tumors: historical pilot evaluation between endoscopic submucosal dissection and conventional mucosal resection. Gastrointest Endosc. 2006;63:776–82.
Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines 2014 (ver. 4). Gastric Cancer. 2017;20:1–19.
Watanabe T, et al. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer. Int J Clin Oncol. 2018;23:1–34.
Ferlitsch M, et al. Colorectal polypectomy and endoscopic mucosal resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline. Endoscopy. 2017;49:270–97.
Schmidt A, et al. Colonoscopic full-thickness resection using an over-the-scope device: a prospective multicentre study in various indications. Gut. 2018;67:1280–9.
Gotoda T, et al. Extending and limitation of the indication for endoscopic mucosal resection of gastric mucosal cancer. The importance of histological evaluation and the necessity of one-piece resection for endoscopic gastric mucosal resection. Stomach Intestine. 2002;37:1145–54.
Toyonaga T, et al. Principles of quality controlled endoscopic submucosal dissection with appropriate dissection level and high quality resected specimen. Clin Endosc. 2012;45:362–74.
Yahagi N, et al. Endoscopic submucosal dissection for the reliable en bloc resection of colorectal mucosal tumors. Dig Endosc. 2004;16:s89–92.
Yahagi N, et al. Endoscopic submucosal dissection for early gastric cancer using the tip of an electrosurgical snare (thin type). Dig Endosc. 2004;16:34–8.
Matsuda T, et al. Laparoscopic endoscopic cooperative surgery (LECS) for the upper gastrointestinal tract. Transl Gastroenterol Hepatol. 2017;2:40.
Kitagawa Y, et al. Sentinel node mapping for gastric cancer: a prospective multicenter trial in Japan. J Clin Oncol. 2013;31:3704–10.
Goto O, et al. First case of non-exposed endoscopic wall-inversion surgery with sentinel node basin dissection for early gastric cancer. Gastric Cancer. 2015;18:434–9.
Maehata T, et al. Cutting edge of endoscopic full-thickness resection for gastric tumor. World J Gastrointest Endosc. 2015;7:1208–15.
Gotoda T, et al. Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers. Gastric Cancer. 2000;3:219–25.
Hirasawa T, et al. Incidence of lymph node metastasis and the feasibility of endoscopic resection for undifferentiated-type early gastric cancer. Gastric Cancer. 2009;12:148–52.
Kitajima K, et al. Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study. J Gastroenterol. 2004;39:534–43.
Oyama T, et al. Diagnosis and long-term results and prognosis of m3 and sm1 esophageal cancer. Lymph nodal metastasis of m3, sm1 esophageal cancer. Stomach Intestine. 2002;37:71–4.
Paris workshop on columnar metaplasia in the esophagus and the esophagogastric junction, Paris, France, December 11–12 2004. Endoscopy. 2005;37:879–920.
Uraoka T, et al. Endoscopic indications for endoscopic mucosal resection of laterally spreading tumours in the colorectum. Gut. 2006;55:1592–7.
Oyama T. Counter traction makes endoscopic submucosal dissection easier. Clin Endosc. 2012;45:375–8.
Sakamoto H, et al. Pocket-creation method facilitates endoscopic submucosal dissection of colorectal laterally spreading tumors, non-granular type. Endosc Int Open. 2017;5:E123–9.
Sakamoto T, et al. Learning curve associated with colorectal endoscopic submucosal dissection for endoscopists experienced in gastric endoscopic submucosal dissection. Dis Colon Rectum. 2011;54:1307–12.
Toyonaga T, et al. The new resources of treatment for early stage colorectal tumors: EMR with small incision and simplified endoscopic submucosal dissection. Dig Endosc. 2009;21(Suppl 1):S31–7.
Pioche M, et al. Randomized comparative evaluation of endoscopic submucosal dissection self-learning software in France and Japan. Endoscopy. 2016;48:1076–83.
Esaki M, et al. Risk factors for local recurrence of superficial esophageal cancer after treatment by endoscopic mucosal resection. Endoscopy. 2007;39:41–5.
Ishihara R, et al. Comparison of EMR and endoscopic submucosal dissection for en bloc resection of early esophageal cancers in Japan. Gastrointest Endosc. 2008;68:1066–72.
Repici A, et al. Endoscopic submucosal dissection in patients with early esophageal squamous cell carcinoma: results from a prospective Western series. Gastrointest Endosc. 2010;71:715–21.
Teoh AY, et al. Outcomes of endoscopic submucosal dissection versus endoscopic mucosal resection in management of superficial squamous esophageal neoplasms outside Japan. J Clin Gastroenterol. 2010;44:e190–4.
Chevaux JB, et al. Clinical outcome in patients treated with endoscopic submucosal dissection for superficial Barrett’s neoplasia. Endoscopy. 2015;47:103–12.
Coman RM, et al. Prospective evaluation of the clinical utility of endoscopic submucosal dissection (ESD) in patients with Barrett’s esophagus: a Western center experience. Endosc Int Open 2016;4:E715–21.
Hirasawa K, et al. Superficial adenocarcinoma of the esophagogastric junction: long-term results of endoscopic submucosal dissection. Gastrointest Endosc. 2010;72:960–6.
Hobel S, et al. Single center experience of endoscopic submucosal dissection (ESD) in early Barrett’s adenocarcinoma. Surg Endosc. 2015;29:1591–7.
Kagemoto K, et al. Clinical outcomes of endoscopic submucosal dissection for superficial Barrett’s adenocarcinoma. Gastrointest Endosc. 2014;80:239–45.
Probst A, et al. Early esophageal cancer in Europe: endoscopic treatment by endoscopic submucosal dissection. Endoscopy. 2015;47:113–21.
Gotoda T, et al. Endoscopic resection of early gastric cancer treated by guideline and expanded National Cancer Centre criteria. Br J Surg. 2010;97:868–71.
Nakamoto S, et al. Indications for the use of endoscopic mucosal resection for early gastric cancer in Japan: a comparative study with endoscopic submucosal dissection. Endoscopy. 2009;41:746–50.
Probst A, et al. Endoscopic submucosal dissection in gastric neoplasia – experience from a European center. Endoscopy. 2010;42:1037–44.
Toyonaga T, et al. 1,635 endoscopic submucosal dissection cases in the esophagus, stomach, and colorectum: complication rates and long-term outcomes. Surg Endosc. 2013;27:1000–8.
Yamamoto Y, et al. Therapeutic outcomes of endoscopic submucosal dissection of undifferentiated-type intramucosal gastric cancer without ulceration and preoperatively diagnosed as 20 millimetres or less in diameter. Dig Endosc. 2010;22:112–8.
Saito Y, et al. A prospective, multicenter study of 1111 colorectal endoscopic submucosal dissections (with video). Gastrointest Endosc. 2010;72:1217–25.
Niimi K, et al. Long-term outcomes of endoscopic submucosal dissection for colorectal epithelial neoplasms. Endoscopy. 2010;42:723–9.
Nishiyama H, et al. Endoscopic submucosal dissection for laterally spreading tumours of the colorectum in 200 consecutive cases. Surg Endosc. 2010;24:2881–7.
Bang CS, et al. Endoscopic submucosal dissection for early gastric cancer with undifferentiated-type histology: a meta-analysis. World J Gastroenterol. 2015;21:6032–43.
Goto O, et al. Endoscopic submucosal dissection as a staging measure may not lead to worse prognosis in early gastric cancer patients with additional gastrectomy. Dig Liver Dis. 2008;40:293–7.
Takeuchi M, et al. Technical feasibility and oncological safety of diagnostic endoscopic resection for superficial esophageal cancer. Gastrointest Endosc. 2018;88:456–65.
Ikeda A, et al. Endoscopic submucosal dissection (ESD) with additional therapy for superficial esophageal cancer with submucosal invasion. Intern Med. 2015;54:2803–13.
Kawaguchi G, et al. The effectiveness of endoscopic submucosal dissection followed by chemoradiotherapy for superficial esophageal cancer. Radiat Oncol. 2015;10:31.
Uraoka T, et al. Colorectal endoscopic submucosal dissection: is it suitable in western countries? J Gastroenterol Hepatol. 2013;28:406–14.
Yahagi N, et al. Outcomes of endoscopic resection for superficial duodenal epithelial neoplasia. Gastrointest Endosc. 2018;88:676–82.
Hotta K, et al. Criteria for non-surgical treatment of perforation during colorectal endoscopic submucosal dissection. Digestion. 2012;85:116–20.
Kantsevoy SV, et al. Endoscopic suturing closure of large mucosal defects after endoscopic submucosal dissection is technically feasible, fast, and eliminates the need for hospitalization (with videos). Gastrointest Endosc. 2014;79:503–7.
Minami S, et al. Complete endoscopic closure of gastric perforation induced by endoscopic resection of early gastric cancer using endoclips can prevent surgery (with video). Gastrointest Endosc. 2006;63:596–601.
Ikehara H, et al. Gastric perforation during endoscopic resection for gastric carcinoma and the risk of peritoneal dissemination. Br J Surg. 2007;94:992–5.
Jung D, et al. Risk of electrocoagulation syndrome after endoscopic submucosal dissection in the colon and rectum. Endoscopy. 2013;45:714–7.
Toyonaga T, et al. Retrospective study of technical aspects and complications of endoscopic submucosal dissection for laterally spreading tumors of the colorectum. Endoscopy. 2010;42:714–22.
Coda S, et al. Risk factors for cardiac and pyloric stenosis after endoscopic submucosal dissection, and efficacy of endoscopic balloon dilation treatment. Endoscopy. 2009;41:421–6.
Ono S, et al. Predictors of postoperative stricture after esophageal endoscopic submucosal dissection for superficial squamous cell neoplasms. Endoscopy. 2009;41:661–5.
Tsunada S, et al. Case series of endoscopic balloon dilation to treat a stricture caused by circumferential resection of the gastric antrum by endoscopic submucosal dissection. Gastrointest Endosc. 2008;67:979–83.
Hotta K, et al. Learning curve for endoscopic submucosal dissection of large colorectal tumors. Dig Endosc. 2010;22:302–6.
Oda I, et al. Learning curve for endoscopic submucosal dissection of early gastric cancer based on trainee experience. Dig Endosc. 2012;24(Suppl 1):129–32.
Yoshida M, et al. Learning curve and clinical outcome of gastric endoscopic submucosal dissection performed by trainee operators. Surg Endosc. 2017;31:3614–22.
Deprez PH, et al. Current practice with endoscopic submucosal dissection in Europe: position statement from a panel of experts. Endoscopy. 2010;42:853–8.
Gotoda T, et al. A learning curve for advanced endoscopic resection. Gastrointest Endosc. 2005;62:866–7.
Berr F, et al. Experimental endoscopic submucosal dissection training in a porcine model: learning experience of skilled Western endoscopists. Dig Endosc. 2011;23:281–9.
Oyama T, et al. Implementation of endoscopic submucosal dissection (ESD) in Europe: survey after ESD Expert Training Workshops 2009–2018. (ESGE abstr OP300) Endosc. 2019;51(4), in press.
Sauer M, et al. Endoscopic submucosal dissection for flat or sessile colorectal neoplasia >20 mm: a European single-center series of 182 cases. Endosc Int Open. 2016;4:E895–900.
Spychalski M, et al. Colorectal endoscopic submucosal dissection (ESD) in the west – when can satisfactory results be obtained? A single-operator learning curve analysis. Scand J Gastroenterol. 2017;52:1442–52.
Wagner A, et al. Single-center implementation of endoscopic submucosal dissection (ESD) in the colorectum: low recurrence rate after intention-to-treat ESD. Dig Endosc. 2018;30:354–63.
Pimentel-Nunes P, et al. Long-term follow-up after endoscopic resection of gastric superficial neoplastic lesions in Portugal. Endoscopy. 2014;46:933–40.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer International Publishing
About this chapter
Cite this chapter
Oyama, T., Yahagi, N. (2019). Principles of Endoscopic Resection: Diagnostic and Curative Resection of Mucosal Neoplasias. In: Berr, F., Oyama, T., Ponchon, T., Yahagi, N. (eds) Atlas of Early Neoplasias of the Gastrointestinal Tract. Springer, Cham. https://doi.org/10.1007/978-3-030-01114-7_3
Download citation
DOI: https://doi.org/10.1007/978-3-030-01114-7_3
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-01113-0
Online ISBN: 978-3-030-01114-7
eBook Packages: MedicineMedicine (R0)