Au(I)-Phosphine Series Design

  • Raphael Enoque Ferraz de PaivaEmail author
Part of the Springer Theses book series (Springer Theses)


Few works have reported the zinc ejecting capabilities of Au(I) compounds. Compounds of general structure [L-Au-A]n allow the modification of both the leaving ligand L and also the ancillary ligand A for fine-tuning the properties of the overall complex towards the desired biomolecular target. In this chapter we explore the basicity and steric hindrance of the phosphine as well as lability and donating properties of the co-ligand (N-heterocycle vs. Cl−) to design a series of Au(I)-phosphine complexes. This series of Au(I) compounds explores the analogy between the organic and the Lewis acid electrophiles, and we demonstrate that chemoselective auration is useful for probing the nucleocapsid topography. We also examined for comparison the “standard” gold-phosphine compound auranofin which contains a thiosugar co-ligand.


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Authors and Affiliations

  1. 1.Institute of ChemistryUniversity of CampinasCampinasBrazil

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