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International Workshop on Connectomics in Neuroimaging

CNI 2018: Connectomics in NeuroImaging pp 136–145Cite as

Structural Subnetwork Evolution Across the Life-Span: Rich-Club, Feeder, Seeder

Part of the Lecture Notes in Computer Science book series (LNIP,volume 11083)

Abstract

The impact of developmental and aging processes on brain connectivity and the connectome has been widely studied. Network theoretical measures and certain topological principles are computed from the entire brain, however there is a need to separate and understand the underlying subnetworks which contribute towards these observed holistic connectomic alterations. One organizational principle is the rich-club - a core subnetwork of brain regions that are strongly connected, forming a high-cost, high-capacity backbone that is critical for effective communication in the network. Investigations primarily focus on its alterations with disease and age. Here, we present a systematic analysis of not only the rich-club, but also other subnetworks derived from this backbone - namely feeder and seeder subnetworks. Our analysis is applied to structural connectomes in a normal cohort from a large, publicly available life-span study. We demonstrate changes in rich-club membership with age alongside a shift in importance from ’peripheral’ seeder to feeder subnetworks. Our results show a refinement within the rich-club structure (increase in transitivity and betweenness centrality), as well as increased efficiency in the feeder subnetwork and decreased measures of network integration and segregation in the seeder subnetwork. These results demonstrate the different developmental patterns when analyzing the connectome stratified according to its rich-club and the potential of utilizing this subnetwork analysis to reveal the evolution of brain architectural alterations across the life-span.

Keywords

  • Connectome
  • Subnetwork
  • Life-span
  • Rich-club
  • Diffusion

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Notes

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    http://umcd.humanconnectomeproject.org.

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Funding

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 753896.

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Authors and Affiliations

  1. Stroke Division and Massachusetts General Hospital, J. Philip Kistler Stroke Research Center, Harvard Medical School, Boston, MA, USA

    Markus D. Schirmer

  2. Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA

    Markus D. Schirmer

  3. Department of Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany

    Markus D. Schirmer

  4. Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA

    Ai Wern Chung

Authors
  1. Markus D. Schirmer
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  2. Ai Wern Chung
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Correspondence to Markus D. Schirmer .

Editor information

Editors and Affiliations

  1. University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Guorong Wu

  2. University of Dundee, Dundee, UK

    Islem Rekik

  3. Harvard Medical School, Boston, MA, USA

    Markus D. Schirmer

  4. Harvard Medical School, Boston, MA, USA

    Ai Wern Chung

  5. College of Charleston, Charleston, SC, USA

    Brent Munsell

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Schirmer, M.D., Chung, A.W. (2018). Structural Subnetwork Evolution Across the Life-Span: Rich-Club, Feeder, Seeder. In: Wu, G., Rekik, I., Schirmer, M., Chung, A., Munsell, B. (eds) Connectomics in NeuroImaging. CNI 2018. Lecture Notes in Computer Science(), vol 11083. Springer, Cham. https://doi.org/10.1007/978-3-030-00755-3_15

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  • DOI: https://doi.org/10.1007/978-3-030-00755-3_15

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