Systemic Mastocytosis (SM)

  • Reiner Bartl
  • Christoph Bartl


An increase of marrow mast cells together with plasma cells and lymphocytes has been observed in a variety of conditions: inflammations, wound and fracture healing, oedema and fibrosis (Fig. 76.1). Immunocytic and lymphocytic marrow infiltrations often have a high content of mast cells. Certain tumours may contain numerous mast cells. Mast cell proliferation as osseous surfaces is also a consequence of primary and secondary HPT. There is also a relation between mast cells and postmenopausal osteoporosis, suggesting that mast cells accelerate trabecular bone loss.


Mast cell Systemic mastocytosis Trabecular bone loss Urticaria pigmentosa Mast cell leukaemia 

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Reiner Bartl
    • 1
  • Christoph Bartl
    • 1
    • 2
  1. 1.Osteoporosis and Bone CenterMunichGermany
  2. 2.Center of Orthopaedics and Sports MedicineMunichGermany

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