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Basic immunology: the fetus and the newborn

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Congenital toxoplasmosis

Abstract

Immaturity of the developing immune system in the fetus and neonate renders them susceptible to a variety of pathogens, including Toxoplasma gondii. Recent advances in understanding fetal and neonatal immunity, cytokines, and immunogenetics, combined with new knowledge of the biology of T. gondii provide important insights relevant to this potentially devastating infection. Cell-mediated immune responses are the major mechanisms of host defense against T. gondii infection. Herein, we consider ontogeny of innate and specific cell-mediated immune responses in the human fetus and neonate in conjunction with a discussion of immune mechanisms likely to protect humans against T gondii, studies of immunity of humans with congenital and postnatally acquired toxoplasmosis, and work which demonstrates immune mechanisms important in protection against toxoplasmosis in murine models.

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Authors
  1. R. McLeod
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  2. M. Dowel
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Editors and Affiliations

  1. Faculté de Médecine de Grenoble, Université Joseph Fourier, Grenoble, France

    Pierre Ambroise-Thomas

  2. Statenserum Institut, Copenhagen, Denmark

    Peter Eskild Petersen

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McLeod, R., Dowel, M. (2000). Basic immunology: the fetus and the newborn. In: Ambroise-Thomas, P., Petersen, P.E. (eds) Congenital toxoplasmosis. Springer, Paris. https://doi.org/10.1007/978-2-8178-0847-5_4

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  • DOI: https://doi.org/10.1007/978-2-8178-0847-5_4

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