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Clinical picture. Neonatal signs and symptoms

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Congenital toxoplasmosis

Abstract

Postnatal infection with the protozoan Toxoplasma gondii is clinically asymptomatic in up to 90 percent of cases[1]. Since the pathogenicity of the parasite for the immunocompetent individual is limited, the course of infection with Toxoplasma gondii is subclinical in most cases, despite the generalized character of the infection with subsequent parasitemia of the host.

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References

  1. Remington JS, McLeod R, Desmonts G (1995) Toxoplasmosis. In: Remington JS, Klein JO (eds) Infectious diseases of the fetus and newborn infant. 4th edn, Philadelphia, WB Saunders, pp 140–267

    Google Scholar 

  2. Thalhammer O (1983) Toxoplasmose und Schwangerschaft. Prophylaxe, Früherkennung und Therapie. Zbl Gynäkol 105:1086–1092

    CAS  Google Scholar 

  3. Gratzl R, Hayde M, Kohlhauser Ch, Hermon M, Burda G, Strobl W, Pollak A (1998) Follow-up of Infants with Congenital Toxoplasmosis detected by polymerase chain reaction analysis of amniotic fluid. Eur J Clin Microbiol Inf Dis 17:853–858

    Article  CAS  Google Scholar 

  4. Hayde M, Pollak A, Gratzl R, Hermon M, Trittenwein G, Häusler M, Arzt W, Bernaschek G (1996) Die Bedeutung der Nachsorge von Kindern mit pränataler Toxoplasma-Infektion. Mitt Oesterr Ges Tropenmed Parasitol 18:125–130

    Google Scholar 

  5. Wolf A, Cowen D, Paige BH (1939) Toxoplasmic encephalomyelitis. A case of granulomatous encephalomyelitis due to a protozoan. Am J Pathol 15:657–694

    CAS  Google Scholar 

  6. Desmonts G, Couvreur J (1979) Congenital toxoplasmosis: a prospective study of 542 women who acquired toxoplasmosis during pregnancy. In: Thalhammer O, Baumgarten K, Pollak A (eds), Pathophysiology of congenital disease, Perinatal Medicine 6`h European Congress, Georg Thieme, Stuttgart, pp. 51–60

    Google Scholar 

  7. Koppe JG, Kloostermann GJ, Roever-Bonnet H, Eckert-Stroink JA, Loewer-Sieger DH, Bruijne JI (1974) Toxoplasmosis and pregnancy, with a long-term follow up of the children. Eur J Obstet Gynaecol Reprod Biol 4:101–110

    Article  Google Scholar 

  8. Wilson CB, Remington JS, Stagno S, Reynolds DW (1980) Development of adverse sequeleae in children born with subclinical congenital toxoplasma infection. Pediatrics 66:767–774

    PubMed  CAS  Google Scholar 

  9. Thalhammer O (1967) Pränatale Erkrankungen des Menschen. Georg Thieme Verlag, Stuttgart, pp 121–157

    Google Scholar 

  10. Thalhammer O (1966) Die angeborene Toxoplasmose. In: Kirchhoff H, Kräubig H (eds). Toxoplasmose. Georg Thieme, Stuttgart, pp. 161-173

    Google Scholar 

  11. Raue W (1975) Die Klinik der konnatalen Toxoplasmose. In: Wildführ G, Wildführ W (eds). Toxoplasmose. VWB Gustav Fischer Verlag, Jena, pp. 135–150

    Google Scholar 

  12. Desmonts G, Couvreur J (1974) Toxoplasmosis. In: Conn RB (ed) Current diagnosis 7. WB Saunders Company, Philadelphia, pp. 274–297

    Google Scholar 

  13. Feldman HA (1958) Toxoplasmosis. Pediatrics 22:559–574

    PubMed  CAS  Google Scholar 

  14. Eichenwald HA (1960) A study of congenital toxoplasmosis, with particular emphasis on clinical manifestations, sequelae and therapy. In: Slim JC (ed) Human Toxoplasmosis. Munksgaard, Copenhagen, pp 41–49

    Google Scholar 

  15. Couvreur J, Desmonts G (1962) Congenital and maternal toxoplasmosis. Dev Med Child Neurol 4:519–530

    Article  PubMed  CAS  Google Scholar 

  16. Alford CA, Stagno S, Reynolds DW (1974) Congenital toxoplasmosis: clinical, laboratory and therapeutical considerations, with special reference to subclinical disease. Bull NY Acad Med 50:160–181

    Google Scholar 

  17. Chatterton JMW (1992) Pregnancy. In: HoYen D, Alex WL Joss (eds) Human Toxoplasmosis, Medical Publications, Oxford, New York, Tokyo, pp.144–183

    Google Scholar 

  18. McAuley J, Boyer KM, Patel D, Mets M, Swisher C, Roizen N, Wolters C, Stein L, Stein M, Schey W, Remington J, Meier P, Johnson D, Heydeman P, Holfels E, Withers S, Mack D, Brown C, Patton D, McLeod R (1994) Early and Longitudinal Evaluations of Treated Infants and Children and Untreated Historical Patients with Congenital Toxoplasmosis: The Chicago Collaborative Treatment Trial. Clin Inf Dis 18:38–72

    Article  CAS  Google Scholar 

  19. Guerina NG, Hsu HW, Meissner CH, Maguire JH, Lynfield R, Stechenberg B, Abroms I, Pasternack MS, Hoff R, Eaton RB, Grady GF (1994) Neonatal serologic screening and early treatment for Congenital Toxoplasma gondii infection. N Engl J Med 330:1858–1863

    Article  PubMed  CAS  Google Scholar 

  20. Couvreur J, Demonts G, Tournier G, et al (1984) Étude d’une série homogène de 210 cases de toxoplasmose congénitale chez des nourissons ages de 0 a 11 mois et dépistes de facon prospective. Annales de Pediatrie 31:815-819

    PubMed  CAS  Google Scholar 

  21. Hohlfeld P, Daffos F, Thulliez Ph, Aufrant C, Couvreur J, MacAleese J, Descombey D, Forestier F (1989) Fetal toxoplasmosis: Outcome of pregnancy and infant follow-up after in utero treatment. J Pediatrics 115:765–769

    Article  CAS  Google Scholar 

  22. Daffos F, Forestier F, Capella-Pavlovsky M, Thulliez Ph, Aufrant C, Valenti D, Cox WL (1988) Prenatal management of 746 pregnancies at risk for congenital toxoplasmosis. N Engl J Med 318:271–275

    Article  PubMed  CAS  Google Scholar 

  23. Roizen N, Swisher CN, Stein MA, Hopkins J, Boyer KM, Holfels E, Mets MB, Stein L, Patel D, Meier P, Withers S, Remington J, Mack D, Heydemann PT, Patton D, McLeod R (1995) Neurologic and developmental outcome in treated congenital toxoplasmosis. Pediatrics 1:11–20

    Google Scholar 

  24. Koppe JG, Loewer-Sieger DH, Roever-Bonnet H (1986) Results of 20-Year Follow-up of Congenital Toxoplasmosis. Lancet 1:254–255

    Article  PubMed  CAS  Google Scholar 

  25. Couvreur J, Thulliez Ph, Daffos F, Aufrant Ch, Bompard Y, Gesquière A, Desmonts G (1993) In utero Treatment of Toxoplasmic Fetopathy with the Combination Pyrimethamine-Sulfadiazine. Fetal Diagn Ther 8:45–50

    Article  PubMed  CAS  Google Scholar 

  26. Villena I, Aubert D, Leroux B, Dupouy D, Talmud M, Chemla C, Trenque T, Schmit G, Quereux C, Guenounou M, Pluot M, Bonhomme A, Pinon JM (1998) Pyrimethamine-sulfadoxine Treatment of Congenital Toxoplasmosis: Follow-up of 78 cases between 1980 and 1997. Scand J Infect Dis 30:295–300

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. M. Hayde
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  2. A. Pollak
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Editor information

Editors and Affiliations

  1. Faculté de Médecine de Grenoble, Université Joseph Fourier, Grenoble, France

    Pierre Ambroise-Thomas

  2. Statenserum Institut, Copenhagen, Denmark

    Peter Eskild Petersen

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© 2000 Springer-Verlag France

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Hayde, M., Pollak, A. (2000). Clinical picture. Neonatal signs and symptoms. In: Ambroise-Thomas, P., Petersen, P.E. (eds) Congenital toxoplasmosis. Springer, Paris. https://doi.org/10.1007/978-2-8178-0847-5_12

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  • DOI: https://doi.org/10.1007/978-2-8178-0847-5_12

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-287-59664-3

  • Online ISBN: 978-2-8178-0847-5

  • eBook Packages: Springer Book Archive

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