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Effect of treatment of the infected pregnant woman and her foetus

  • Conference paper
Congenital toxoplasmosis

Abstract

If primary Toxoplasma infection is identified in a pregnant woman today, antiparasitic treatment is mandatory. The aim is primarily to prevent the mother-to-foetal transmission and secondly to treat or reduce any damage in an already infected foetus. Whenever foetal infection is diagnosed, two options are considered: pregnancy termination or continuation of pregnancy with antiparasitic treatment of the infected maternal-foetal unit.

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References

  1. Stray-Pedersen B (1992) Toxoplasmosis in pregnancy. In: Gilbert GL (ed) Infectious Diseases. Challenges for the 1990’s. Bailliere’s Clinical Obstetrics and Gynaecology, Bailliere Tindall, London 17:1–107

    Article  Google Scholar 

  2. Wallon M (1998) Prévention primaire et secondaire de la toxoplasmose congénitale: evaluation et propositions pour une meilleure efficacité. (Thesis, University of Lyon), pp 1–227

    Google Scholar 

  3. Stray-Pedersen B (1992) Treatment of Toxoplasmosis in the Pregnant Mother and Newborn Child. Scand J Infect Dis (Suppl) 84:23–31

    CAS  Google Scholar 

  4. WHO publication (1988) Report of the WHO consultation on Public Health Aspects of Toxoplasmosis. WHO/CDS/VPH 74:2–14

    Google Scholar 

  5. Schoondermark-Van de Ven E, Galama J, Vree T, Camps W, Baars I, Eskes T, Meuwissen J, Melchers W (1995) Study of Treatment of Congenital Toxoplasma gondii Infection in Rhesus Monkeys with Pyrimethamine and Sulfadiazine. Antimicrob Agents Chemother 39:137–144

    Article  Google Scholar 

  6. Desmonts G, Couvreur J (1974) Congenital toxoplasmosis. A prospective study of 378 pregnancies. N Eng J of Med 290:1110–1116

    Article  CAS  Google Scholar 

  7. Daffos F, Forestier F, Capella-Pavlovsky M, Thulliez P, Aufrant C, Valenti D, Cox WL (1988) Prenatal management of 746 pregnancies at risk for congenital toxoplasmosis. N Engl J Med 318:271–275

    Article  PubMed  CAS  Google Scholar 

  8. Schoondermark-Van de Ven E, Galama J, Camps W, Vree T, Russel F, Meuwissen J, Melchers W (1994) Pharmacokinetics of Spiramycin in the Rhesus Monkey: Transplacental Passage and Distribution in Tissue in the Fetus. Antimicrob Agents Chemother 38:1922–1929

    Article  Google Scholar 

  9. Couvreur J, Desmonts G, Thulliez P (1988) Prophylaxis of congenital toxoplasmosis. Effects of spiramycin on placental infection. J Antimicrob Chemiother 22:193–200

    Google Scholar 

  10. Editorial (1983) Pyrimethamine combination in pregnancy. Lancet ii: 1005–1007

    Google Scholar 

  11. WHO publication (1990) WHO Model Prescribing Information on Drugs used in Parasitic Diseases. Geneva WHO, pp 53–60

    Google Scholar 

  12. Villena I, Aubert D, Leroux B, Dupouy D, Talmud M, Chemla C, Trenque T, Schmit G, Quereux C, Guenounou M, Plutot M, Bonhomme A, Pinon JM (1998) Pyrimethaminesulfadoxine Treatment of Congenital Toxoplasmosis: Follow-up of 78 Cases Between 1980 and 1997. Scand J Infect Dis 30:295–300

    Article  PubMed  CAS  Google Scholar 

  13. Remington JS, McLeod R, Desmonts G (1995) Toxoplasmosis In: Remington JS, Klein JO (eds) Infectious diseases of the fetus and newborn.Vol 4 WB Saunders, Philadelphia, pp 140–267

    Google Scholar 

  14. Stray-Pedersen B (1996) Azithromycin Levels in Placental Tissue, Amniotic Fluid and Blood. Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, Sept 15–18, Abstract A68

    Google Scholar 

  15. Brockelhurst P, Rooney G (1998) The treatment of chlamydia trachomitis infection in pregnancy. The Cochrane Database of Systematic Reviews 4

    Google Scholar 

  16. Kovacs JA (1992) Efficacy of atovaquone in treatment of toxoplasmosis in patients with AIDS. Lancet 340:637–638

    Article  PubMed  CAS  Google Scholar 

  17. Briggs GG, Freeman RK, Yaffe SJ (eds) (1998) Drugs in Pregnancy and Lactation. Williams and Wilkins, Baltimore

    Google Scholar 

  18. Vergani P, Ghidini A, Ceruti P, Strobelt N, Spelta A, Zapparoli B, Rescaldani R (1998) Congenital toxoplasmosis: efficacy of maternal treatment with spiramycin alone. Am J Reprod Immun 39:335–340

    Article  CAS  Google Scholar 

  19. Schoondermark-Van de Ven E, Melchers W, Camps W, Eskes T, Meuwissen J, Galama J (1994) Effectiveness of Spiramycin for Treatment of Congenital Toxoplasma gondii Infection in Rhesus Monkeys. Antimicrob Agents Chemother 38:1930–1936

    Article  Google Scholar 

  20. Lebeck M, Joynson DHM, Seitz HM, Thulliez P, Gilbert RE, Dutton GN, Oevlisen B, Petersen E (1996) Classification System and Case Definitions of Toxoplasma gondii Infection in Immunocompetent Pregnant Women and Their Congenitally Infected Offspring. Eur J Clin Microbiol Infect Dis 15:799–805

    Article  Google Scholar 

  21. Desmonts G, Couvreur J (1974) L’isolement du parasite dans la toxoplasmose congenitale. Arch Franç Péd 31:157–166

    CAS  Google Scholar 

  22. Couvreur J, Thulliez P, Daffos F, Aufrant C, Bompard Y, Gesquiere A, Desmonts G (1993) In utero treatment of toxoplasmic fetopathy with the combination pyrimethamine-sulfadiazine. Fetal Diagn Ther 8:45–50

    Article  PubMed  CAS  Google Scholar 

  23. Eskild A, Oxman A, Magnus P, Björndal A, Bakketeig L (1996) Screening for toxoplasmosis in pregnancy: what is the evidence of reducing a health problem? J Med Screen 3:88–194

    Google Scholar 

  24. Desmonts G, Couvreur J (1984) Toxoplasmose congénitale. Etude prospective de L’issue de la grossesse chez 542 femmes atteintes de toxoplasmose acquise en cours de gestation. Annales de Pédiatrie 31:805–809

    PubMed  CAS  Google Scholar 

  25. Excler JL, Piens MA, Maisonneuve H, Pujol E, Garin JP (1985) Dépistage de la toxoplasmose acquise chez la femme enceinte et de la toxoplasmose congénitale chez le nouveau-né. Lyon Med 253:3–38

    Google Scholar 

  26. Lambotte R, Bassleer J, Beaudouin PH, Senterre J, Lhoist R (1976) Toxoplasmose congénitale: evaluation du bénéfice thérapeutique prénatal. J Gynecol Obstet Biol Reprod (Paris) 5:265–269

    CAS  Google Scholar 

  27. Douche C, Benabdesselam A, Mokhtari F, Le Mer Y (1996) Value of prevention of congenital toxoplasmosis. J Fr Ophtalmol 19:330–334

    PubMed  CAS  Google Scholar 

  28. Wallon M, Peyron F, Lebech M, Petersen E, Gilbert R, Dunn D (1997) Prenatal treatment and the risk of congenital toxoplasmosis: preliminary findings from two cohort studies. European Society for Pediatric Research, Hungary

    Google Scholar 

  29. Lebech M, Andersen O, Christensen NC, Nielsen HE, Hertel J, Peitersen B, Rechnitzer C, Larsen SO, Norgaard-Pedersen B, Petersen E (1999) Feasibility of neonatal screening for Toxoplasma infection in the absence of prenatal treatment. Danish Congenital Toxoplasmosis Study Group. Lancet 353:1834–7

    CAS  Google Scholar 

  30. Foulon W, Villena I, Stray-Pedersen B, Decoster A, Lappalainen M, Pinon M, Jenum PA, Redman K, Naessens A (1999) Treatment of toxoplasmosis during pregnancy: a multicenter study of impact on fetal transmission and children’s sequelae at one year of age. American J Obstet Gynecol 180:410–5

    Article  CAS  Google Scholar 

  31. Hohlfeld P, Daffos F, Thulliez P, Aufrant C, Couvreur J, MacAleese J, Descombey D, Forestier F (1989) Fetal toxoplasmosis: Outcome of pregnancy and infant follow-up after in utero treatment. J Pediatrics 115:765–769

    Article  CAS  Google Scholar 

  32. Dunn D, Wallon M, Peyron F, Petersen E, Peckham C, Gilbert R (1999) Mother-to-child transmission of toxoplasmosis: Risk estimates for clinical counselling. Lancet 353:1829–1833

    Article  PubMed  CAS  Google Scholar 

  33. Berrebi A, Kobuch WE, Bessieres MH, Bloom MC, Rolland M, Sarramon MF, Roques C, Fournie A (1994) Termination of pregnancy for maternal toxoplasmosis. Lancet 344:36–39

    Article  PubMed  CAS  Google Scholar 

  34. Wallon M, Gandilhon F, Peyron F, Mojon M (1994) Toxoplasmosis in pregnancy (letter). Lancet 344:541

    Article  PubMed  CAS  Google Scholar 

  35. Daffos F, Mirlesse V, Hohlfeld P, Jacquemard F, Thulliez P, Forestier F (1994) Toxoplasmosis in pregnancy (Letter). Lancet 344:541

    Article  PubMed  CAS  Google Scholar 

  36. Jenum PA (1999) Diagnosis and epidemiology of Toxoplasma gondii infection among pregnant women in Norway (Thesis, National Institute of Public Health), pp 1–412

    Google Scholar 

  37. Mitchell CD, Erlich SS, Mastrucci MT, Hutto SC, Parks W, Scott GB (1990) Congenital toxoplasmosis occurring in infants perinatally infected with human immunodeficiency virus 1. Pediatr Infect Dis J 9:512

    Article  PubMed  CAS  Google Scholar 

  38. Dunn D, Newell ML, Gilbert R (1997) Low risk of congenital toxoplasmosis in children infected with human immunodeficiency virus. Ped Infect Dis J 16(1):84

    Article  CAS  Google Scholar 

  39. Minkoff H, Remington JS, Holman S, Ramirez R, Goodwin S, Landesman S (1997) Vertical transmission of Toxoplasma by human immunodeficiency virus-infected women. Am J Obstet Gynecol 176:555–559

    Article  PubMed  CAS  Google Scholar 

  40. American Academy of Pediatrics (1998) Antiretroviral Therapy and Medical Management of Pediatric HIV Infection. Pediatrics 102(4S-Ií):1005–1062

    Google Scholar 

  41. Wong S-Y, Remington JS (1994) State-of-the-art clinical article. Clin Inf Dis 18:853–862

    Article  CAS  Google Scholar 

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Authors
  1. B. Stray-Pedersen
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  2. W. Foulon
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Editor information

Editors and Affiliations

  1. Faculté de Médecine de Grenoble, Université Joseph Fourier, Grenoble, France

    Pierre Ambroise-Thomas

  2. Statenserum Institut, Copenhagen, Denmark

    Peter Eskild Petersen

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© 2000 Springer-Verlag France

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Stray-Pedersen, B., Foulon, W. (2000). Effect of treatment of the infected pregnant woman and her foetus. In: Ambroise-Thomas, P., Petersen, P.E. (eds) Congenital toxoplasmosis. Springer, Paris. https://doi.org/10.1007/978-2-8178-0847-5_11

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  • DOI: https://doi.org/10.1007/978-2-8178-0847-5_11

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-287-59664-3

  • Online ISBN: 978-2-8178-0847-5

  • eBook Packages: Springer Book Archive

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