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Induction chemotherapy with Methotrexate, Vinblastine, Epiadriamycin and Carboplatin (M-VEP) in transitional cell urothelial cancer

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Proceedings of the 3rd International Congress on Neo-Adjuvant Chemotherapy

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Abstract

Radical cystectomy remains the standard treatment for patients with transitional cell urothelial carcinoma (TUCC) of the bladder with muscle invasion and/or N 0–2. However, 70–80% of these patients eventually die of disseminated disease. Systemic treatment might eradicate co-existing metastases [1]. Cisplatin, Methotrexate, Fluorouracil, Vinblastine, Mitomycin and Carboplatin have been used as single agents in metastatic disease, with 20–35% overall response (OR) being reported. Combinations including Cisplatin yield a relatively high OR (45–70%) and complete response (CR) rate. A 75% OR with 35% CR was reported with the M-VAC (Methotrexate, Vinblastine, Adriamycin, Cisplatin) regimen [2, 3].

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References

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Authors and Affiliations

  1. 3rd Medical Oncology Dept, Agii Anargiri cancer hospital, Kifissia, Athens, Greece

    G. Aravantinos, D. V. Skarlos, H. Linardou, C. Christodoulou, C. Deliveliotis, A. Kostakopoulos, T. Vardoulakis & K. Dimopoulos

  2. Dept of Urology, University of Athens, Greece

    G. Aravantinos, D. V. Skarlos, H. Linardou, C. Christodoulou, C. Deliveliotis, A. Kostakopoulos, T. Vardoulakis & K. Dimopoulos

Authors
  1. G. Aravantinos
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  2. D. V. Skarlos
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  3. H. Linardou
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  4. C. Christodoulou
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  5. C. Deliveliotis
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  6. A. Kostakopoulos
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  7. T. Vardoulakis
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  8. K. Dimopoulos
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Editor information

Editors and Affiliations

  1. Hôpital Saint-Louis, 1, avenue Vellefaux, 75475, Paris Cedex 10, France

    P. Banzet

  2. The Mount Sinai Medical Center, 1 G. Levy Place, 10029-6574, New York, NY, USA

    J. F. Holland

  3. Service d’Oncologie Médicale, Hôpital Pitié-Salpétrière, Pavillon Jacquart, 47, boulevard de l’Hôpital, 75651, Paris Cedex 13, France

    D. Khayat

  4. Hôpital Pitié-Salpétrière, Pavillon Jacquart, 47, boulevard de l’Hôpital, 75651, Paris Cedex 13, France

    M. Weil

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© 1991 Springer-Verlag France

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Aravantinos, G. et al. (1991). Induction chemotherapy with Methotrexate, Vinblastine, Epiadriamycin and Carboplatin (M-VEP) in transitional cell urothelial cancer. In: Banzet, P., Holland, J.F., Khayat, D., Weil, M. (eds) Proceedings of the 3rd International Congress on Neo-Adjuvant Chemotherapy. Springer, Paris. https://doi.org/10.1007/978-2-8178-0782-9_28

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  • DOI: https://doi.org/10.1007/978-2-8178-0782-9_28

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0784-3

  • Online ISBN: 978-2-8178-0782-9

  • eBook Packages: Springer Book Archive

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