Abstract
Since 1986 we have conducted trials investigating chemoradiotherapy in poor prognosis head and neck cancer. The first study employed 5-Fluorouracil, hydroxyurea and concomitant radiation therapy given on an alternate week schedule in patients with locally advanced or recurrent head and neck cancer. These two drugs were chosen for their potential synergism with each other and to enhance the effectiveness of radiation [1]. A second phase I trial attempted to modulate the original regimen through the addition of Cisplatin. Cisplatin was chosen as the third agent based on high single agent activity in many solid tumors, radiation enhancing properties and synergistic action with 5-FU in vitro [1]. We now present an analysis of the long term results in 65 patients treated on these two trials.
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References
Vokes EE, Weichselbaum RR (1990) Concomitant chemoradiotherapy: rationale and clinical experience in patients with solid tumors. J Clin Onc 8: 911–934
Yokes EE, Panje WR, Schilsky RL et al (1989) Hydroxyurea, fluorouracil and concomitant radiotherapy in poor prognosis head and neck cancer: a phase I-II study. J Clin Onc 7: 761–768
Moormeier JA, Vokes EE, Haraf DJ et al Cisplatin (CDDP), 5-Fluorouracil (FU), and hydroxyurea (HU) with concomitant radiotherapy (RT) for advanced solid tumors. Third International Conference on the Interaction of Radiation Therapy and Systemic Therapy, Monterey, CA
Yokes EE, Choi KE, Schilsky RL et al (1988) Cisplatin, fluorouracil and high-dose leucovorin for recurrent ‘or metastatic head and neck cancer. J Clin Onc 6: 618–626
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© 1991 Springer-Verlag France
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Haraf, D.J., Vokes, E.E., Panje, W.R., Weichselbaum, R.R. (1991). Efficacy of concomitant chemoradiotherapy in poor prognosis head and neck cancer. In: Banzet, P., Holland, J.F., Khayat, D., Weil, M. (eds) Proceedings of the 3rd International Congress on Neo-Adjuvant Chemotherapy. Springer, Paris. https://doi.org/10.1007/978-2-8178-0782-9_15
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DOI: https://doi.org/10.1007/978-2-8178-0782-9_15
Publisher Name: Springer, Paris
Print ISBN: 978-2-8178-0784-3
Online ISBN: 978-2-8178-0782-9
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