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Cisplatin, 5-Fluorouracil and high dose oral Leucovorin (PFL) with Methotrexate and Piritrexim as Neo-Adjuvant chemotherapy for head and neck cancer

  • Conference paper
Proceedings of the 3rd International Congress on Neo-Adjuvant Chemotherapy

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Abstract

Studies in head and neck cancer at the University of Chicago have focused on the biochemical modulation of 5-Fluorouracil (5-FU). This has included the addition of high dose oral Leucovorin to the combination of Cisplatin and continuous infusion 5-FU (PFL). After establishing the pattern of toxicities, the recommended doses, and the efficacy of PFL in recurrent and/or metastatic disease [1], we treated patients with locally advanced disease with this PFL regimen and identified a high degree of activity [2, 3]. Piritrexim (PTX) is a MTX-analogue with single agent activity in head and neck cancer [4]. Since it is lipid soluble, it requires no active transportation and, therefore, may be able to overcome transport-related MTX resistance. In this phase II study, we added MTX and PTX to the PFL regimen (PFL-MP) hoping to further increase its activity.

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References

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Author information

Authors and Affiliations

  1. Departments of Medicine, Section of Hematology/Oncology, of Surgery, Section of Otolaryngology Head and Neck Surgery, of Radiation and Cellular Oncology, The University of Chicago Medical Center, Chicago, IL, 60637 1470, USA

    D. J. Haraf, W. R. Panje, J.-M. McEvilly, M. F. Kozloff, D. Goldman, N. Clendeninn, A. G. Tybor, M. Collier & R. R. Weichselbaum

  2. Research Triangle Park, Burroughs Wellcome Co., N.C., 27709, USA

    D. J. Haraf, W. R. Panje, J.-M. McEvilly, M. F. Kozloff, D. Goldman, N. Clendeninn, A. G. Tybor, M. Collier & R. R. Weichselbaum

  3. Assistant Professor of Medicine and Radiation Oncology, University of Chicago, 5841 S. Maryland Ave., Box 420, Chicago, IL, 60637-1470, USA

    Everett E. Vokes MD

Authors
  1. Everett E. Vokes MD
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  2. D. J. Haraf
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  3. W. R. Panje
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  4. J.-M. McEvilly
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  5. M. F. Kozloff
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  6. D. Goldman
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  7. N. Clendeninn
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  8. A. G. Tybor
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  9. M. Collier
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  10. R. R. Weichselbaum
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Editor information

Editors and Affiliations

  1. Hôpital Saint-Louis, 1, avenue Vellefaux, 75475, Paris Cedex 10, France

    P. Banzet

  2. The Mount Sinai Medical Center, 1 G. Levy Place, 10029-6574, New York, NY, USA

    J. F. Holland

  3. Service d’Oncologie Médicale, Hôpital Pitié-Salpétrière, Pavillon Jacquart, 47, boulevard de l’Hôpital, 75651, Paris Cedex 13, France

    D. Khayat

  4. Hôpital Pitié-Salpétrière, Pavillon Jacquart, 47, boulevard de l’Hôpital, 75651, Paris Cedex 13, France

    M. Weil

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© 1991 Springer-Verlag France

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Vokes, E.E. et al. (1991). Cisplatin, 5-Fluorouracil and high dose oral Leucovorin (PFL) with Methotrexate and Piritrexim as Neo-Adjuvant chemotherapy for head and neck cancer. In: Banzet, P., Holland, J.F., Khayat, D., Weil, M. (eds) Proceedings of the 3rd International Congress on Neo-Adjuvant Chemotherapy. Springer, Paris. https://doi.org/10.1007/978-2-8178-0782-9_14

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  • DOI: https://doi.org/10.1007/978-2-8178-0782-9_14

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0784-3

  • Online ISBN: 978-2-8178-0782-9

  • eBook Packages: Springer Book Archive

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