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Abstract

We have attempted to increase the efficacy of available chemotherapy for head and neck cancer through modulation of 5-FU. We took the combination of Cisplatin and 5-Fluorouracil as our base, since it had proven activity and a moderate toxicity profile that might allow for modulation [1, 2]. Our goal was to identify a regimen that would have a higher degree of activity resulting in improved survival.

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References

  1. Rooney M, Kish J, Jacobs J et al (1985) Improved complete response rate and survival in advanced head and neck cancer after three-course induction therapy with 120-hour 5-FU infusion and cisplatin. Cancer 55: 1123–1128

    Article  PubMed  CAS  Google Scholar 

  2. Yokes EE, Mick R, Lester EP, Panje WR, Weichselbaum RR (1991) Cisplatin and 5-Fluorouracil does not yield longterm benefit in locally advanced head and neck cancer: results from a single institution (in preparation)

    Google Scholar 

  3. Yokes EE, Moran WJ, Mick R, Weichselbaum RR, Panje WR (1989) neo-adjuvant and adjuvant methotrexate, cisplatin and fluorouracil in multimodal therapy of head and neck cancer. J Clin Oncol 7: 838–845

    Google Scholar 

  4. Yokes EE, Panje WR, Mick R, Kozloff MF, Moran WJ, Sutton HG, Goldman MD, Tybor AG, and Weichselbaum RR (1990) A randomized study comparing two regimens of neo-adjuvant and adjuvant chemotherapy in multimodal therapy for locally advanced head and neck cancer. Cancer 66: 206–213

    Article  Google Scholar 

  5. Vokes EE, Choi KE, Schilsky RL, Moran WJ, Guarnieri CM, Weichselbaum RR, and Panje WR (1988) Cisplatin, fluorouracil, and high-dose leucovorin for recurrent or metastatic head and neck cancer. J Clin Oncol 6: 618–626

    PubMed  CAS  Google Scholar 

  6. Yokes EE, Schilsky RL, Weichselbaum RR, Panje WR (1990) Induction chemotherapy with cisplatin, fluorouracil, and high-dose leucovorin for locally advanced head and neck cancer: a clinical and pharmacologic analysis. J Clin Oncol 8: 241–247

    Google Scholar 

  7. Yokes EE, Panje WR, Mick R, Haraf DJ, Moran WJ, McEvilly JM, Kozloff M, Weichselbaum (1990) neo-adjuvant chemotherapy surgery and concomitant chemoradiotherapy for locally advanced head and neck cancer. Proc ASCO 9: 174

    Google Scholar 

  8. Dreyfuss AI, Clark JR, Wright JE, Norris CM, Jr, Busse PM, Lucarini JW, Fallon BG, Casey D, Andersen JW, Klein R, Rosowsky A, Miller D, Frei E, III (1990) Continuous infusion high-dose leucovorin with 5-Fluorouracil and cisplatin for untreated stage IV carcinoma of the head and neck. Annals of Internal Medicine 112: 167–172

    Article  PubMed  CAS  Google Scholar 

  9. Vokes EE and Weichselbaum RR (1990) Concomitant chemoradiotherapy: rationale and clinical experience in patients with solid tumors. J Clin Oncol 8: 911–934

    PubMed  CAS  Google Scholar 

  10. Yokes EE, Panje WR, Schilsky RL, Mick R, Moran WJ, Awan AM, Goldman MD, Tybor AG, Weichselbaum RR (1989) Hydroxyurea, fluorouracil, and concomitant radiotherapy in poor-prognosis head and neck cancer: a phase I-II Study. J Clin Oncol 7: 761–768

    Google Scholar 

  11. Haraf DJ, Yokes EE, Panje WR, Weichselbaum RR (1990) Survival and analysis of failure following hydroxyurea, 5-Fluorouracil and concomitant radiation therapy in poor prognosis head and neck cancer. Am J Clin Oncol (in press)

    Google Scholar 

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© 1991 Springer-Verlag France

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Vokes, E.E., Panje, W.R., Weichselbaum, R.R. (1991). 5-Fluorouracil modulation in head and neck cancer. In: Banzet, P., Holland, J.F., Khayat, D., Weil, M. (eds) Proceedings of the 3rd International Congress on Neo-Adjuvant Chemotherapy. Springer, Paris. https://doi.org/10.1007/978-2-8178-0782-9_13

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  • DOI: https://doi.org/10.1007/978-2-8178-0782-9_13

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0784-3

  • Online ISBN: 978-2-8178-0782-9

  • eBook Packages: Springer Book Archive

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