Abstract
Blood leukocytes consist of a heterogeneous group of specialized immune cells including lymphocytes, granulocytes and monocytes, which circulate through the vasculature in a quiescent state of low adhesiveness before migrating into tissues. Lymphocytes recirculate between tissue compartments during immune surveillance and participate with other leukocytes in defending against invading microorganisms. Several families of adhesion molecules expressed on endothelial cells, the extracellular matrix and on leukocytes are required to mediate the effective and specific recruitment of leukocytes from inside the vasculature to extravascular sites where they can fulfill their specific task.
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Ley, K., Sperandio, M. (2003). Molecular Mechanisms of Leukocyte Adhesion. In: Molecular Basis for Microcirculatory Disorders. Springer, Paris. https://doi.org/10.1007/978-2-8178-0761-4_2
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