Midterm and Long-Term Impacts of GnRH Agonists Treatments
GnRH analogs treatment is effective on final height, especially when treatment is started before the age of 6 years old.On average, the BMI of girls with precocious puberty treated with GnRH analogs is higher than the BMI of girls from the general population. However, large variability is reported in the literature.GnRH analogs treatment does not seem to alter final postpubertal bone maturation.GnRH analogs treatment does not seem to alter fertility of men and women treated during their infancy.Few data have been reported concerning psychological evaluations of children treated during their infancy by GnRH analog treatment for precocious puberty.
KeywordsBone Mineral Density Final Height Adult Height Precocious Puberty GnRH Analog
- 2.Heger S, Partsch CJ, Sippell WG (1999) Long-term outcome after depot gonadotropin-releasing hormone agonist treatment of central precocious puberty: final height, body proportions, body composition, bone mineral density, and reproductive function. J Clin Endocrinol Metab 84:4583–4590PubMedGoogle Scholar
- 4.Pasquino A, Pucarelli I, Accardo F et al (2008) Long-term observation of 87 girls with idiopathic central precocious puberty treated with gonadotropin-releasing hormone analogs: impact on adult height, body mass index, bone mineral content, and reproductive function. J Clin Endocrinol Metab 93:190–195CrossRefPubMedGoogle Scholar
- 13.Feuillan PP, Jones JV, Barnes K et al (1999) Reproductive axis after discontinuation of gonadotropin-releasing hormone analog treatment of girls with precocious puberty: long term follow-up comparing girls with hypothalamic hamartoma to those with idiopathic precocious puberty. J Clin Endocrinol Metab 84:44–49CrossRefPubMedGoogle Scholar