Clinical and Biological Diagnosis of Central Precocious Puberty

  • Juliane LégerEmail author
  • Jean Claude Carel


Precocious puberty (PP) is defined as the onset of clinical signs of puberty before the age of 8 years in girls and 9.5 years in boys. It may be caused by central or peripheral mechanisms. Central PP (CPP) results from premature reactivation of the hypothalamo-pituitary-gonadal axis and pulsatile GnRH secretion, with a hormonal pattern similar to that of normal puberty. CPP may be due to hypothalamic lesions or idiopathic in most cases, particularly in girls. It may have consequences for growth and psychosocial development. Thorough evaluation is required to identify its cause and potential for progression.


Congenital Adrenal Hyperplasia Precocious Puberty Pubic Hair Secondary Sexual Characteristic Height Velocity 
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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Université Paris 7 Diderot, Assistance Publique Hôpitaux de Paris, Service d’Endocrinologie Pédiatrique, Centre de Référence Maladies Endocriniennes de la Croissance, Inserm UMR 1141, DHU PROTECT Hôpital Robert DebréParisFrance

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