Puberty in Particular Situations

  • J. V. de MonléonEmail author
  • L. Goutchkoff
  • M. Cartigny-Maciejewski
  • C. Thomas-Teinturier
  • I. Oliver-Petit


A quarter of girls adopted from 4 to 8 years old.


GnRH Agonist Final Height Adult Height Precocious Puberty Cranial Irradiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Precocious Puberty in Adopted Childrenand Its Differential Diagnoses

  1. 1.
    Bourguignon JP, Gerard A, Alvarez Gonzalez ML, Fawe L, Franchimont P (1992) Effects of changes in nutritional conditions on timing of puberty: clinical evidence from adopted children and experimental studies in the male rat. Horm Res 38:97–105CrossRefPubMedGoogle Scholar
  2. 2.
    de Monléon JV, Simonin G, Sarles J (1998) Puberté précoce et enfants adoptés: une entité à connaître. Concours Med 120:688–690Google Scholar
  3. 3.
    de Monléon JV, Geneste B, Huet F (1999) Puberté précoce chez les enfants adoptés, un risque à ne pas oublier. Arch Pediatr 6:589–590CrossRefPubMedGoogle Scholar
  4. 4.
    Proos LA, Hofvander Y, Tuvemo T (1991) Menarcheal age and growth pattern of Indian girls adopted in Sweden. Acta Paediatr Scand 80:852–858CrossRefPubMedGoogle Scholar
  5. 5.
    de Monléon JV (2000) Adoption à l’étranger: les risques médicaux. Rev Prat Med Gen 14(493):557–562Google Scholar
  6. 6.
    Tuvemo T, Proos LA (1993) Girls adopted from developing countries: a group at risk of early pubertal development and short final height: implications for health surveillance and treatment. Ann Med 25:217–219CrossRefPubMedGoogle Scholar
  7. 7.
    Virdis R, Street ME, Zamolli M, Radetti G, Pezzini B, Benelli M, Ghizzoni L, Volta C (1998) Precocious puberty in girls adopted from developing countries. Arch Dis Child 78:152–154PubMedCentralCrossRefPubMedGoogle Scholar
  8. 8.
    Proos LA (2009) Growth & development of Indian children adopted in Sweden. Indian Med J Res 130(5):646–650Google Scholar
  9. 9.
    Teilmann G, Petersen JH, Damgaard K, Skakkebaek NE, Jensen TK (2009) Early puberty in internationally adopted girls: hormonal and clinical markers of puberty in 276 girls examined biannually over two years. Horm Res 72(4):236–246CrossRefPubMedGoogle Scholar
  10. 10.
    Choulot JJ, Mechain S, Saint Martin J, Doireau V, Mensire A (1998) Adoption et portage chronique du virus B. Arch Pediatr 5:869–872CrossRefPubMedGoogle Scholar
  11. 11.
    Le Masne A (1999) Attitude du pédiatre chez l’enfant adopté à l’étranger. Arch Pediatr 6:569–572CrossRefGoogle Scholar
  12. 12.
    Teilmann G, Petersen JH, Gormsen M, Damgaard K, Skakkebaek NE, Jensen TK (2009) Early puberty in internationally adopted girls: hormonal and clinical markers of puberty in 276 girls examined biannually over two years. Horm Res 72(4):236–246CrossRefPubMedGoogle Scholar
  13. 13.
    Goutchkoff L (2011) Puberté précoce chez les petites filles adoptées l’étranger [thèse]. Université de Bourgogne, DijonGoogle Scholar
  14. 14.
    Parent AS, Teilamnn G, Juul A, Skakkebaek NE, Toppari J, Bourguignon JP (2003) The timing of normal puberty and the age limits of sexual precocity: variations around the world, seculare trends, and change after migration. Endocr Rev 24(5):668–693CrossRefPubMedGoogle Scholar
  15. 15.
    Chiguer N (2013) Parasitoses digestives et troubles du transit chez des enfants adoptés à l’étranger [thèse]. Université de Bourgogne, DijonGoogle Scholar

Puberty of Child Born Small for Gestational Age

  1. 16.
    Fowden AL, Forhead AJ (2004) Endocrine mechanisms of intrauterine programming. Reproduction 127:515–526CrossRefPubMedGoogle Scholar
  2. 17.
    Barker DJ (1995) Intrauterine programming of adult disease. Mol Med Today 1:418–423CrossRefPubMedGoogle Scholar
  3. 18.
    Davies MJ, Norman RJ (2002) Programming and reproductive functioning. Trends Endocrinol Metab 13:386–392CrossRefPubMedGoogle Scholar
  4. 19.
    Lazar J, Pollak U, Kalter-Leibovici O et al (2003) Pubertal course of persistently short children born small for gestational age (SGA) compared with idiopathic short children born appropriate for gestational age (AGA). Eur J Endocrinol 149:425–432CrossRefPubMedGoogle Scholar
  5. 20.
    Veening MA, Van Weissenbruch MM, Roord JJ et al (2004) Pubertal development in children born small for gestational age. J Pediatr Endocrinol Metab 17:1497–1505CrossRefPubMedGoogle Scholar
  6. 21.
    Hokken-Koèlega AC (2002) Timing of puberty and fetal growth. Best Pract Res Clin Endocrinol Metab 16:65–71CrossRefPubMedGoogle Scholar
  7. 22.
    Herman-Giddens ME, Slora EJ, Wasserman RC et al (1997) Secondary sexual characteristics and menses in young girls seen in office practice: a study from the Pediatric Research in Office Settings Network. Pediatrics 99:505–512CrossRefPubMedGoogle Scholar
  8. 23.
    Preece MA (1997) Puberty in children with intrauterine growth retardation. Horm Res 48(Suppl 1):30–32CrossRefPubMedGoogle Scholar
  9. 24.
    Leger J, Levy Marchal C, Boch J et al (1997) Reduced final height and indications for early development of insulin resistance in a 20 year old population born with intrauterine growth retardation. Br Med J 315:341–347CrossRefGoogle Scholar
  10. 25.
    Bhargava SK, Ramji S, Srivastava U et al (1995) Growth and sexual maturation of low birth weight children: a 14 year follow up. Indian Pediatr 32:963–970PubMedGoogle Scholar
  11. 26.
    Persson I, Ahlsson F, Ewald U et al (1999) Influence of perinatal factors on the onset of puberty in boys and girls: implication for interpretation of link with risk of long term diseases. Am J Epidemiol 150:747–755CrossRefPubMedGoogle Scholar
  12. 27.
    Ibanez L, de Zegher F (2006) Puberty after prenatal growth restraint. Horm Res 65(Suppl 3):112–115PubMedGoogle Scholar
  13. 28.
    Ghirri P, Bernardini M, Vuerich M et al (2001) Adrenarche, pubertal development, age at menarche and final height of full term, born small for gestational age (SGA) girls. Gynecol Endocrinol 15:91–97PubMedGoogle Scholar
  14. 29.
    Vicens-Calvet E, Espadero RM, Carrascosa A et al (2002) Small for gestational age. Longitudinal study of the pubertal growth spurt in children born small for gestational age without postnatal catch-up growth. J Pediatr Endocrinol Metab 15:381–388CrossRefPubMedGoogle Scholar
  15. 30.
    Job JC, Rolland A (1986) Natural history of intrauterine growth retardation: pubertal growth and adult height. Arch Fr Pediatr 43:301–306PubMedGoogle Scholar
  16. 31.
    Luo ZC, Albertsson-Wikland K, Karlberg J (1998) Length and body mass index at birth and target height influences on patterns of postnatal growth in children born small for gestational age. Pediatrics 102, E72CrossRefPubMedGoogle Scholar
  17. 32.
    Dos Santos SI, De Stavola BL, Mann V et al (2002) Prenatal factors, childhood growth trajectories and age at menarche. Int J Epidemiol 31:405–412CrossRefGoogle Scholar
  18. 33.
    Dunger DB, Ahmed ML, Ong KK (2006) Early and late weight gain and the timing of puberty. Mol Cell Endocrinol 254:140–145CrossRefPubMedGoogle Scholar
  19. 34.
    Ong KK, Potau N, Cj P et al (2004) Opposing influences of prenatal and postnatal weight gain on adrenarche in normal boys and girls. J Clin Endocrinol Metab 89:2647–2651CrossRefPubMedGoogle Scholar
  20. 35.
    Neville KA, Walker HJL (2005) Precocious pubarche is associated with SGA, prematurity, weight gain and obesity. Arch Dis Child 90:258–261PubMedCentralCrossRefPubMedGoogle Scholar
  21. 36.
    Ibanez L, Potau N, Francois I et al (1998) Precocious pubarche, hyperinsulinism and ovarian hyperandrogenism in girls : relation to reduced fetal growth. J Clin Endocrinol Metab 83:3558–3662CrossRefPubMedGoogle Scholar
  22. 37.
    Ibanez L, Potau N, Marcos MV et al (1999) Exaggerated adrenarche and hyperinsulinism in adolescent girls born small for gestational age. J Clin Endocrinol Metab 84:4739–4741CrossRefPubMedGoogle Scholar
  23. 38.
    Ibanez L, Jaramillo A, Enriquez G et al (2007) polycystic ovaries after precocious pubarche: relation to prenatal growth. Hum Reprod 22:395–400CrossRefPubMedGoogle Scholar
  24. 39.
    Cicognani A, Alessandroni R, Pasini A et al (2002) Low birth weight for gestational age and subsequent male gonadal function. J Pediatr 141:376–379CrossRefPubMedGoogle Scholar
  25. 40.
    Ibanez L (2003) Hypergonadotrophinemia with reduced uterine and ovarian size in women born small for gestational age. Hum Reprod 18:1565–1569CrossRefPubMedGoogle Scholar
  26. 41.
    Melo A, Vieira CS, Barbier MA et al (2010) High prevalence of polycystic ovary syndrome in women born small for gestational age. Hum Reprod 25:2124–2131CrossRefPubMedGoogle Scholar

Characteristics of Puberty After Cranial Irradiation in Childhood

  1. 42.
    Leiper AD, Stanhope R, Kitching P, Chessels JM (1987) Precocious and premature puberty associated with treatment of acute lymphoblastic leukemia. Arch Dis Child 62:1107–1112PubMedCentralCrossRefPubMedGoogle Scholar
  2. 43.
    Quigley C, Cowell C, Jimenez M et al (1989) Normal or early development of puberty despite gonadal damage in children treated for acute lymphoblastic leukemia. N Engl J Med 321:143–151CrossRefPubMedGoogle Scholar
  3. 44.
    Hokken-Koelega AC, van Doorn JW, Hahlen K et al (1993) Long-term effects of treatment for acute lymphoblastic leukemia with and without cranial irradiation on growth and puberty: a comparative study. Pediatr Res 33:577–582CrossRefPubMedGoogle Scholar
  4. 45.
    Ogilvy-Stuart AL, Clayton P, Shalet S (1994) Cranial irradiation and early puberty. J Clin Endocrinol Metab 78:1282–1286PubMedGoogle Scholar
  5. 46.
    Oberfield SE, Soranno D, Niremberg A et al (1996) Age at the onset of puberty following high-dose central nervous system radiation therapy. Arch Pediatr Adolesc Med 150:589–592CrossRefPubMedGoogle Scholar
  6. 47.
    Ogilvy-Stuart AL, Shalet S (1995) Growth and puberty after growth hormone treatment after irradiation for brain tumours. Arch Dis Child 73:141–146PubMedCentralCrossRefPubMedGoogle Scholar
  7. 48.
    Lannering B, Jansson C, Rosberg S, Albertsson-Wikland K (1997) Increased LH and FSH secretion after cranial irradiation in boys. Med Pediatr Oncol 29:280–287CrossRefPubMedGoogle Scholar
  8. 49.
    Maneschi F, Fugardi MG, Corsello G, LoCurto M (1991) Pubertal maturation in girls treated for childhood acute leukaemia. Eur J Pediatr 150:630–633CrossRefPubMedGoogle Scholar
  9. 50.
    Didcock E, Davies HA, Didi M et al (1995) Pubertal growth in young adult survivors of childhood leukaemia. J Clin Oncol 13:2503–2507PubMedGoogle Scholar
  10. 51.
    Chow EJ, Friedman DL, Yasui Y et al (2008) Timing of menarche among survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor study. Pediatr Blood Cancer 50:854–858CrossRefPubMedGoogle Scholar
  11. 52.
    Armstrong GT, Whitton JA, Gajjar A et al (2009) Abnormal timing of menarche in survivors of central nervous system tumors. Cancer 115:2562–2570PubMedCentralCrossRefPubMedGoogle Scholar
  12. 53.
    Noorda EM, Somers R, Van Leeuwen FE et al (2001) Adult height and age at menarche in childhood cancer survivors. Eur J Cancer 37:605–612CrossRefPubMedGoogle Scholar
  13. 54.
    Mills JL, Fears TR, Robison LL et al (1997) Menarche in a cohort of 188 long-term survivors of acute lymphoblastic leukaemia. J Pediatr 131:598–602CrossRefPubMedGoogle Scholar
  14. 55.
    Roth C, Schmidberger H, Schaper O et al (2000) Cranial irradiation of female rats causes dose-dependent and age-dependent activation or inhibition of pubertal development. Pediatr Res 47:586–591CrossRefPubMedGoogle Scholar
  15. 56.
    Armstrong GT, Chow EJ, Sklar CA (2009) Alterations in pubertal timing following therapy for childhood malignancies. In: Wallace WHB, Kelnar CJH (eds) Endocrinopathy after Childhood cancer treatment, Endocrine development. Karger, Basel, pp 25–39CrossRefGoogle Scholar
  16. 57.
    Clayton PE, Shalet SM (1991) Dose dependency of time of onset of radiation-induced growth hormone deficiency. J Pediatr 118:226–228CrossRefPubMedGoogle Scholar
  17. 58.
    Gleeson HK, Shalet SM (2004) The impact of cancer therapy on the endocrine system in survivors of childhood brain tumours. Review. Endocr Relat Cancer 11:591–602CrossRefGoogle Scholar
  18. 59.
    Chemaitilly W, Sklar CA (2010) Endocrine complications in long-term survivors of childhood cancers. Endocr Relat Cancer 17:141–159CrossRefGoogle Scholar
  19. 60.
    Spoudeas HA (2002) Growth and endocrine function after chemotherapy and radiotherapy in childhood. Eur J Cancer 38:1748–1759CrossRefPubMedGoogle Scholar
  20. 61.
    Lerner SE, Huang JM, McMahon D et al (2004) Growth hormone therapy in children after cranial/craniospinal radiation therapy: sexually dimorphic outcomes. J Clin Endocrinol Metab 89:6100–6104CrossRefPubMedGoogle Scholar
  21. 62.
    Toogood AA (2004) Endocrine consequences of brain irradiation. Growth Horm IGF Res 14:S118–S124CrossRefPubMedGoogle Scholar
  22. 63.
    Partsch CJ, Heger S, Sippell WG (2002) Management and outcome of central precocious puberty. Clin Endocrinol (Oxf) 56:129–148CrossRefGoogle Scholar
  23. 64.
    Adan L, Sainte-Rose C, Souberbielle JC et al (2000) Adult height after growth hormone (GH) treatment for GH deficiency due to cranial irradiation. Med Pediatr Oncol 34:14–19CrossRefPubMedGoogle Scholar
  24. 65.
    Gleeson HK, Stoeter R, Ogilvy-Stuart AL et al (2003) Improvements in final height over 25 years in growth hormone (GH)-deficient childhood survivors of brain tumors receiving GH replacement. J Clin Endocrinol Metab 88:3682–3689CrossRefPubMedGoogle Scholar
  25. 66.
    Stephen MD, Zage PE, Waguespack SG (2011) Review. Gonadotropin-dependent precocious puberty: Neoplastic causes and endocrine considerations. Int J Pediatr Endocrinol 2011:184502PubMedCentralCrossRefPubMedGoogle Scholar
  26. 67.
    Wit JM, Hero M, Nunez SB (2012) Aromatase inhibitors in pediatrics. Nat Rev Endocrinol 8:135–147CrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • J. V. de Monléon
    • 1
    Email author
  • L. Goutchkoff
    • 1
  • M. Cartigny-Maciejewski
    • 4
  • C. Thomas-Teinturier
    • 2
  • I. Oliver-Petit
    • 3
  1. 1.Hôpital d’EnfantsDIJON CedexFrance
  2. 2.Pediatric Endocrinology DepartmentAP-HP Hôpital BicêtreLe Kremlin BicêtreFrance
  3. 3.Unité d’endocrinologie, Hopital des enfantsToulouse cedex9France
  4. 4.Pediatrie UnityHôpital Jeanne De Flandre, CHRULille cedexFrance

Personalised recommendations