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Soluble Vascular Endothelial (VE)-Cadherin: Toward a Marker of Endothelial Dysfunction

Abstract

Endothelial dysfunction is a hallmark for vascular diseases. It is often seen in patients with coronary artery disease, diabetes, hypertension, rheumatoid arthritis, systemic vasculitis, and cancer. Identification of serologic markers that are associated with disease activity to diagnose or predict relapse is a challenging task. At the cellular level, endothelial dysfunction is the result of activation of several signaling pathways due to increased levels of cytokines associated with the disease. Endothelium integrity is dependent upon the adhesive function of the major molecule located at endothelial adherens junctions called vascular endothelial (VE)-cadherin. As in the case of other members of the cadherin family, VE-cadherin is able to mediate homotypic types of endothelial cellular interactions in a Ca2+-dependent manner and to link the underlying cytoskeleton. In conditions mimicking endothelial cell activation, the junctional complexes are subjected to posttranslational modifications such as phosphorylations or proteolysis reactions mediated by kinases and proteases, respectively, which are supposed to weaken the junctional strength. This chapter summarizes recent studies on VE-cadherin structural modifications in endothelial biology having potential applications in disease management and patient care.

Keywords

  • Hereditary Angioedema
  • Severe OHSS
  • Endothelial Cell Permeability
  • Tyrosine Kinase Inhibitor Genistein
  • Transendothelial Permeability

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Sidibé, A., Polena, H., Mannic, T., Stidder, B., Bouillet, L., Vilgrain, I. (2014). Soluble Vascular Endothelial (VE)-Cadherin: Toward a Marker of Endothelial Dysfunction. In: Feige, JJ., Pagès, G., Soncin, F. (eds) Molecular Mechanisms of Angiogenesis. Springer, Paris. https://doi.org/10.1007/978-2-8178-0466-8_23

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