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Résection des adénocarcinomes pancréatiques: les limites du raisonnable

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Post’U FMC-HGE
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Résumé

Le diagnostic de l’adénocarcinome céphalique repose sur un faisceau d’arguments cliniques, morphologiques et biologiques; lorsque ces arguments convergent, la preuve histologique avant la résection pancréatique n’est pas exigée [14]. La biopsie par voie échoendoscopique est utile en cas de doute diagnostique car elle peut permettre d’éviter une laparotomie et a fortiori une résection, inutiles comme par exemple dans les pancréatites «auto-immunes» ou chroniques [4]. En pratique, les contre-indications formelles àa un geste d’exérèse àa visée curative admises par tous sont:

  1. 1)

    la présence d’une carcinose péritonéale ou de métastases hépatiques;

  2. 2)

    l’envahissement d’une ou plusieurs adénopathies lombo-aortiques;

  3. 3)

    un envahissement du tronc coeliaque, de l’artère hépatique ou de l’artère mésentérique supérieure;

  4. 4)

    une thrombose de l’axe veineux mésentérico-portal associée àa un cavernome portal. En revanche, lorsque l’axe veineux est perméable, l’envahissement veineux n’est qu’une contre-indication relative àa une exérèse «d’emblée», sous réserve de critères précis permettant d’espérer une résection curative de type R0 [14].

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Références

  1. Cancer du pancréas (Thésaurus National de Cancérologie Digestive) http://www.snfge.asso.fr/01-Bibliotheque/0D-Pratiques-cliniques/referentiels.asp

  2. Recommandations de pratiques chirurgicales 2009 — (SFCD / ACHBT labellisées INCa-HAS) Pancréas: A Sauvanet, JR Delpero. http://www.snfge.asso.fr/01-Bibliotheque/0D-Pratiques-cliniques/Reco_hors_HAS/recos_chir_sfcd_long.pdf

  3. Slim K. Cancérologie digestive: pratiques chirurgicales. J Chir 2009;146 (Suppl. 2):S11–S80.

    Google Scholar 

  4. Delpero JR. Quand ne pas biopsier une masse solide du pancréas? Association nationale française de formation continue en hépato-gastroentérologie. In: Post’U. Springer Éd., 104–12 http://www.snfge.asso.fr/01-Bibliotheque/0B-ConferencesFlash/2009/267/indexConf.asp

  5. Zins M. Adénocarcinome pancréatique: bilan d’extension. Traité de pancréatologie clinique, Levy P, Ruszniewski P, Sauvanet A. Flammarion Medecine-Sciences, Paris, 2005. 168–77.

    Google Scholar 

  6. Hidalgo M. Pancreatic Cancer. N Engl J Med 2010;362:1605–17.

    Article  PubMed  CAS  Google Scholar 

  7. Bipat S, Phoa S, van Delden O, et al. Ultrasonography, Computed Tomography and Magnetic Resonance Imaging for Diagnosis and determining Resectability of Pancreatic Adenocarcinoma: a Metaanalysis. J Comput Assist Tomogr 2005;29: 438–45.

    Article  PubMed  Google Scholar 

  8. Michl P, Pauls S, Gress TM. Evidence based diagnosis and staging of pancreatic cancer. Best Pract Res Clin Gastroenterol 2006;20:227–51.

    Article  PubMed  Google Scholar 

  9. Puli SR, Singh S, Hagedorn CH, Reddy J, Olyaee M. Diagnostic accuracy of EUS for vascular invasion in pancreatic and periampullary cancers: a metaanalysis and systematic review. Gastrointest Endosc 2007;65:788–97.

    Article  PubMed  Google Scholar 

  10. Dewitt J, Devereaux BM, Lehman GA, et al. Comparison of endoscopic ultrasound and computed tomography for the preoperative evaluation of pancreatic cancer: a systematic review. Clin Gastroenterol Hepatol 2006;4:717–25.

    Article  PubMed  Google Scholar 

  11. Hirokawa Y, Isoda H, Okada T, Arizono S, Shimada K, Yamamoto A, et al. Improved detection of hepatic metastases from pancreatic cancer using periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) technique after SPIO administration. Invest Radiol 2010;45:158–64.

    Article  PubMed  Google Scholar 

  12. Wakabayashi H, Nishiyama Y, Otani T, et al. Role of 18F-fluorodeoxyglucose positron emission tomography imaging in surgery for pancreatic cancer. World J Gastroenterol 2008;14:64–9.

    Article  PubMed  Google Scholar 

  13. Maire F, Sauvanet A, Trivin F, et al. Staging of pancreatic head adenocarcinoma with spiral CT and endoscopic ultrasonography: an indirect evaluation of the usefulness of laparoscopy. Pancreatology 2004;4:436–40.

    Article  PubMed  Google Scholar 

  14. Pancreatic Section of the British Society of Gastroenterology, Pancreatic Society of Great Britain and Ireland, Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland, Royal College of Pathologists, Special Interest Group for Gastro-Intestinal Radiology. Guidelines for the management of patients with pancreatic cancer periampullary and ampullary carcinomas. Gut 2005;54:v1–v16.

    Article  Google Scholar 

  15. Vullierme MP, Giraud-Cohen M, Hammel P, et al. Malignant intraductal papillary mucinous neoplasm of the pancreas: in situ versus invasive carcinoma surgical resectability. Radiology 2007;245:483–90.

    Article  PubMed  Google Scholar 

  16. Sa Cunha A, Rault A, Laurent C, et al. Surgical resection after radiochemotherapy in patients with unresectable adenocarcinoma of the pancreas. J Am Coll Surg 2005;201:359–65.

    Article  Google Scholar 

  17. Turrini O, Viret F, Moureau-Zabotto L, Guiramand J, et al. Neoadjuvant chemoradiation and pancreaticoduodenectomy for initially locally advanced head pancreatic adenocarcinoma. Eur J Surg Oncol 2009;35:1306–11.

    Article  PubMed  CAS  Google Scholar 

  18. Evans DB, Farnell MB, Lillemoe KD, Vollmer C Jr, Strasberg SM, Schulick RD. Surgical Treatment of Resectable and Borderline Resectable Pancreas Cancer: Expert Consensus Statement. Ann Surg Oncol 2009;16:1736–44.

    Article  PubMed  Google Scholar 

  19. Chun YS, Milestone BN, Watson JC, Cohen SJ, et al. Defining venous involvement in borderline resectable pancreatic cancer. Ann Surg Oncol 2010;17:2832–8.

    Article  PubMed  Google Scholar 

  20. Delpero JR, Paye F, Bachellier P. Cancer du Pancréas. Monographies de l’association Française de Chirurgie. Arnette, Wolters Kluwer France, 2010.

    Google Scholar 

  21. Ishikawa O, Ohigashi H, Imaoka S, et al. Preoperative indications for extended pancreatectomy for locally advanced pancreas cancer involving the portal vein. Ann Surg 1992;215:231–6.

    Article  PubMed  CAS  Google Scholar 

  22. Hirano S, Kondo S, Hara T, et al. Distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic body cancer: long-term results. Ann Surg 2007;246:46–51.

    Article  PubMed  Google Scholar 

  23. Delpero JR, Turrini O. Adénocarcinomes pancréatiques céphaliques: une étude critique du taux des marges de résection positives. Bull Cancer 2008;95:1193–8.

    PubMed  Google Scholar 

  24. AJCC Cancer Staging Manual, Sixth Edition, Exocrine pancreas, 2002: 157–64.

    Google Scholar 

  25. Pedrazzoli S, Di Carlo V, Dionigi R, et al. Standard versus extended lymphadenectomy associated with pancreaticoduodenectomy in the surgical treatment of adenocarcinoma of the head of pancreas. A multicenter, prospective, randomized study. Ann Surg 1998;228:508–17.

    Article  PubMed  CAS  Google Scholar 

  26. Nimura Y, Nagino M, Kato H, et al. Regional versus extended lymph node dissection in radical pancreatoduodenectomy for pancreatic cancer. A multicenter, randomized controlled trial (abstract). J Intern HPB Ass 2004;6 (Suppl I):2.

    Google Scholar 

  27. Farnell MB, Pearson RK, Sarr MG, et al. A prospective randomized trial comparing standard pancreatoduodenectomy with pancreatoduodenectomy with extended lymphadenectomy in resectable pancreatic head adenocarcinoma. Surgery 2005;138:628–30.

    Article  Google Scholar 

  28. Riall TS, Cameron JL, Lillemoe KD, et al. Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma-part 3: update on 5-year survival. J Gastrointest Surg 2005;9:1191–1204.

    Article  PubMed  Google Scholar 

  29. Chang DK, Johns AL, Merrett ND, et al. Margin Clearance and Outcome in Resected Pancreatic Cancer. J Clin Oncol 2009;27:2855–62.

    Article  PubMed  Google Scholar 

  30. Bhatti I, Peacock O, Awan AK, Semeraro D, Larvin M, Hall RI. Lymph Node Ratio versus Number of Affected Lymph Nodes as Predictors of Survival for Resected Pancreatic Adenocarcinoma. World J Surg 2010;34:768–75

    Article  PubMed  Google Scholar 

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Correspondence to J. R. Delpero .

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Philippe Lévy

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Delpero, J.R. (2011). Résection des adénocarcinomes pancréatiques: les limites du raisonnable. In: Lévy, P. (eds) Post’U FMC-HGE. Springer, Paris. https://doi.org/10.1007/978-2-8178-0237-4_25

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  • DOI: https://doi.org/10.1007/978-2-8178-0237-4_25

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