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Biothérapies en développement dans l’arthrose

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Résumé

L’arthrose est de loin la plus fréquente des affections rhumatologiques. Elle affecte, audelà de 55 ans, plus de 50 % de la population. Il ne s’agit pas seulement d’une maladie du cartilage. Il existe en effet une inflammation précoce de la membrane synoviale, un renouvellement accéléré de l’os sous-chondral, mais également des modifi cations des structures para-articulaires qui jouent un role important dans l’évolution de la maladie.

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Références

  1. Zhang W, Moskowitz RW, Nuki G et al. (2008) OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage 16:137–62

    Article  PubMed  CAS  Google Scholar 

  2. Pelletier JP, Martel-Pelletier J, Abramson SE (2001) Review: Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets. Arthritis Rheum 44:1237–47

    Article  PubMed  CAS  Google Scholar 

  3. Chevalier X (1998) Physiopathogenesis of osteoarthritis. The osteoarthritic cartilage. Presse Med 27: 81–7

    PubMed  CAS  Google Scholar 

  4. Benito MJ, Veale D, Fitzgerald O et al. (2002) Synovial tissue from patients with early osteoarthritis exhibits prominent features of inflammation. Arthritis Rheum 46(Suppl 9) S252:604

    Google Scholar 

  5. Ayral X, Pickering EH, Woodworth TG, Mackillop N, Dougados M. (2001) Synovitis predicts the arthroscopic progression of medial tibiofemoral knee osteoarthritis. Arthritis Rheum 44 Suppl 9: 952

    Google Scholar 

  6. Goldring Sr, Goldring MB (2004) The role of cytokines in cartilage matrix degeneration in osteoarthritis. Clin Orthop Rel Res (427 Suppl): S27–36

    Article  Google Scholar 

  7. Chevalier X (1997) Up-regulation of enzymatic activity by interleukin-1 in osteoarthritis. Biomedicine Pharmacotherapy 51: 58–62

    Article  PubMed  CAS  Google Scholar 

  8. Caron IP, Fernandes JC, Martel-Pelletier J et al. (1996) Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression. Arthritis Rheum 39:1535–44

    Article  PubMed  CAS  Google Scholar 

  9. Bloom AB, van Lent PL, Holthuysen AE et al. (2004) Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis. Osteoarthritis Cartilage 12: 627–35

    Article  Google Scholar 

  10. Bondenson I (2008) The role of activated synovial macrophages in osteoarthritis. Osteoarthritis Cartilage 16(Suppl 4) S8:1–24

    Google Scholar 

  11. Sachs D, Cunha FQ, Poole S et al. (2002) Tumour necrosis factor-alpha, interleukin-1beta and interleukin-8 induce persistent mechanical nociceptor hypersensitivity. Pain 96:89–97

    Article  PubMed  CAS  Google Scholar 

  12. Chevalier X, Giraudeau B, Conrozier T et al. (2005) Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: a multicenter study. I Rheumatol 32:1317–23

    Google Scholar 

  13. Chevalier X, Goupille P, Beaulieu AD et al. (2009) Intra-Articular Injection of Anakinra (r-met-huIL-1ra) in Osteoarthritis of the Knee: A Multicenter, Randomized, Double-blind, Placebo-controlled Study. Arthritis Rheum 61: 344–52

    Article  PubMed  CAS  Google Scholar 

  14. Loeuille D, Chary-Valckeneare I, Goebel G et al. (2005) MRI evaluation of the synovial membrane after single intra-articular injection of Anakinra in 7 patients with osteoarthritis of the knee suggests anti-inflammatory effect. Arthritis Rheum 52(Suppl 9): S70: 94

    Google Scholar 

  15. Cohen S, Proudman S, Kivitz A et al. (2007) Results of a randomised controlled trial of AMC 108 (a fuUy monoclonal human antibody to IL1R type 1) in patients with osteoarthritis of the knee. Arthritis Rheum 56(Suppl 9): 1684

    Google Scholar 

  16. Grunke M, Schulze-Koops H (2006) Successful treatment of inflammatory knee osteoarthritis with tumour necrosis factor blockade. Ann Rheum Dis 65(4): 555–6

    Article  PubMed  CAS  Google Scholar 

  17. Avouac J, Marini-Portugal A, Chevalier X (2004) A propos d’un cas d’arthrose digitale érosive: réponse spectaculaire aux anti-TNF alpha. Revue Rhum 71: Ma 158

    Google Scholar 

  18. Magnano MD, Chakravarty EF, Broudy C et al. (2007) A pilot study of tumor necrosis factor inhibition in erosive/inflammatory osteoarthritis of the hands. J Rheumatol 34:1323–7

    PubMed  CAS  Google Scholar 

  19. Güler-Yüksel M, Kloppenburg M, AUaart CF et al. (2008) Infliximab might be protective against progressive interphalangeal osteoarthritis. Ann Rheum Dis 67(suppl II): 630: AB0714

    Google Scholar 

  20. Verbruggen G, Wittoek R, Vander C et al. (2009) Preliminary results of a phase II placebo controlled trail with adalimumab in erosive hand osteoarthritis: predictors of erosions and the potential effect of adalimumab in specific sub groups. Arthritis Rheum 60(Suppl 10): 856

    Google Scholar 

  21. Pelletier IP, Caron IP, Evans C, et al. (1997) 1n vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy. Arthritis Rheum 40:1012–9

    Article  PubMed  CAS  Google Scholar 

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© 2011 Springer-Verlag France, Paris

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Chevalier, X., Richette, P., Compaore, C. (2011). Biothérapies en développement dans l’arthrose. In: Biothèrapies en rhumatologie. Springer, Paris. https://doi.org/10.1007/978-2-8178-0124-7_11

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  • DOI: https://doi.org/10.1007/978-2-8178-0124-7_11

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0123-0

  • Online ISBN: 978-2-8178-0124-7

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