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Implications des pathologies hématologiques sur l’assistance médicale à la procréation

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Physiologie, pathologie et thérapie de la reproduction chez l’humain

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Résumé

La pratique de l’assistance médicale à la procréation (AMP) s’est développée ces dernières années et les modalités de la stimulation ovarienne et de la fécondation in vitro (FIV) ont subi des modifications au cours du temps (1). L’une des complications de l’AMP est la survenue de thromboses veineuses ou artérielles. Différentes pathologies hématologiques sont associées à une augmentation du risque de thrombose veineuse, et en particulier les thrombophilies biologiques congénitales (déficits en inhibiteurs physiologiques de la coagulation : antithrombine (AT), protéine C (PC), protéine S (PS), mutation facteur V Leiden (FVL) ou prothrombine G20210A, hyperhomocystéinémie), ou des anomalies acquises (anticoagulant circulant avec augmentation des anticorps antiphospholipides, syndromes myéloprolifératifs : polyglobulie, thrombocythémie essentielle) (tableau I) (2, 3).

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Références

  1. Rossin B, Pouly JL, Belaisch-Allart J et al. (2009) La stimulation de l’ovulation pour fécondation in vitro, en France: choix et résultats en fonction des protocoles et des gonadotrophines. Gynécol Obstét Fertil 37:864–872

    Article  PubMed  CAS  Google Scholar 

  2. Samama MM for the Sirius Study Group (2000) An epidemiologic study of risk factors for deep vein thrombosis in medical outpatients. Arch Intern Med 160:3415–3420

    Article  PubMed  CAS  Google Scholar 

  3. Seligsohn U, Lubetsky A (2001) Genetic susceptibility to venous thrombosis. N Engl J Med 344:1222–1231

    Article  PubMed  CAS  Google Scholar 

  4. Bates SM, Greer IA, Pabinger I et al. (2008) Venous thromboembolism, thrombophilia, antithrombotic therapy and pregnancy. American College of Chest Physicians Evidenced-based Clinical Practice Guidelines (8th Edition) Chest 133:844S–886S

    Article  PubMed  CAS  Google Scholar 

  5. Oger E (2000) Incidence of venous thromboembolism: a community-based study in Western France. EPI-GETBP Study Group. Groupe d'étude de la thrombose de Bretagne occidentale. Thromb Haemost 83:657–660

    PubMed  CAS  Google Scholar 

  6. Prandoni P, Bilora F, Marchiori A et al. (2003) An association between atherosclerosis and venous thrombosis. N Engl J Med 348:1435–1441

    Article  PubMed  Google Scholar 

  7. Conard J, Horellou MH, Samama MM (2009) Grossesse et maladie thromboembolique veineuse. À propos des recommandations nord-américaines et européennes. J M Vascul 34:300–313

    Article  CAS  Google Scholar 

  8. Royal College of Obstetricians and Gynaecologists (RCOG) (2006) The management of ovarian hyperstimulation syndrome. Green-top Guideline N∘5

    Google Scholar 

  9. Boulieu D, Ninet J, Pinède L (1989) Thrombose veineuse précoce de siège inhabituel, en début de grossesse après stimulation ovarienne. Contracept Fertil Sex 17:725–727

    Google Scholar 

  10. Fournet N, Surrey E, Kerin F (1991) Internal jugular vein thrombosis after ovulation induction with gonadotropins. Fertil Steril 56:354–356

    PubMed  CAS  Google Scholar 

  11. Benifla JL, Conard J, Naouri M et al. (1994) Syndrome d’hyperstimulation ovarienne et thrombose. J Gynecol Obstet Biol Reprod 23:778–783

    CAS  Google Scholar 

  12. Stewart JA, Hamilton J, Murdoch AP (1997) Thromboembolic disease associated with ovarian stimulation and assisted conception techniques. Hum Reprod 12:2167–2173

    Article  PubMed  CAS  Google Scholar 

  13. Ou YC, Kao YL, Lai SL et al. (2003) Thromboembolism after ovarian stimulation: successful management of a woman with superior sagittal sinus thrombosis after IVF and embryo transfer: case report. Hum Reprod 18:2375–2381

    Article  PubMed  Google Scholar 

  14. Rao AK, Chitkara U, Milki AA (2005) Subclavian vein thrombosis following IVF and ovarian hyperstimulation: a case report. Hum Reprod 20:3307–3312

    Article  PubMed  Google Scholar 

  15. Chan WS, Dixon ME (2008) The “ART” of thromboembolism: a review of assisted reproductive technology and thromboembolic complications. Thromb Res 121:713–726

    Article  PubMed  CAS  Google Scholar 

  16. Nelson SM, Greer IA (2008) The potential role of heparin in assisted conception. Human Reprod Update 14:623–645

    Article  CAS  Google Scholar 

  17. Jacobsen AF, Skjeldested FE, Sandset PM (2008) Ante-and postnatal risk factors of venous thrombosis: a hospital-based case-control study. J Thromb Haemost 6:905–912

    Article  PubMed  CAS  Google Scholar 

  18. Delvigne A, Demoulin A, Smitz J et al. (19993) The ovarian hyperstimulation syndrome in in-vitro fertilization: a Belgian multicentric study. I. Clinical and biological features. Hum Reprod 8:1353–1360

    Google Scholar 

  19. Mara M, Koryntova D, Kapral et al. (2004) Thromboembolic complications in patients undergoing in-vitro fertilization: retrospective clinical study. Ceska Gynekol. 69:312–316

    PubMed  CAS  Google Scholar 

  20. Bauersachs RM, Manolopoulos K, Hoppe I et al. (2007) More on: the “ART” behind the clot: solving the mystery. J Thromb Haemost 5:438–439

    Article  PubMed  CAS  Google Scholar 

  21. Salomon O, Schiby G, Heiman Z et al. (2009) Combined jugular and subclavian veine thrombosis following assisted reproductive technology-new observation. Fertil Steril 92:620–625

    Article  PubMed  Google Scholar 

  22. Girolami A, Scandellari R, Tezza F et al. (2007) Arterial thrombosis in young women after ovarian stimulation: case report and review of the literature. J Thromb Thrombolysis 24:169–174

    Article  PubMed  Google Scholar 

  23. Aune B, Hoie KE, Oian P et al. (1991) Does ovarian stimulation for in-vitro fertilization induce a hypercoagulable state? Hum Reprod 6:925–927

    PubMed  CAS  Google Scholar 

  24. Biron C, Galtier-Dereure F, Rabesandratana H et al. (1997) Hemostasis parameters during ovarian stimulation for in vitro fertilization: results of a prospective study. Fertil Steril 67:104–109

    Article  PubMed  CAS  Google Scholar 

  25. Curvers J, Nienhuis SJ, Nap AW et al. (2001) Activated protein C resistance during in-vitro fertilization treatment. Eur J Obstet Gynecol Reprod Biol 95:222–224

    Article  PubMed  CAS  Google Scholar 

  26. Balasch J, Reverter JC, Fabregues F et al. (1996) Increased induced monocyte tissue factor expression by plasma from patients with severe ovarian hyperstimulation syndrome. Fertil Steril 66:608–613

    PubMed  CAS  Google Scholar 

  27. Kodama H, Takeda S, Fukuda J et al (1997) Activation of plasma kinin system correlates with severe coagulation disorders in patients with ovarian hyperstimulation syndrome. Human Reprod 12:891–895

    Article  CAS  Google Scholar 

  28. Rogolino A, Coccia ME, Fedi S et al. (2003) Hypercoagulability, high tissue factor and low tissue factor pathway inhibitor levels in severe ovarian hyperstimulation syndrome: possible association with clinical outcome. Blood Coagul Fibrinolysis 14:277–282

    PubMed  CAS  Google Scholar 

  29. Harnett MJP, Bhavani-Shankar K, Datta S, Tsen LC (2002) In-vitro fertilization-induced alterations in coagulation and fibrinolysis as measured by thromboelastography. Anesth Analg 95:1063 6

    PubMed  CAS  Google Scholar 

  30. Binder H, Flegel WA, Emran J et al. (2008) Association of blood group A with early-onset ovarian hyperstimulation syndrome. Transfus Clin Biol 15:395–401

    Article  PubMed  CAS  Google Scholar 

  31. Kodama H, Fukuda J, Karube H et al. (1996) Status of the coagulation and fibrinolytic systems in ovarian hyperstimulation syndrome. Fertil Steril 66:417–424

    PubMed  CAS  Google Scholar 

  32. Fabregues F, Tassies D, Reverter JC et al. (2004) Prevalence of thrombophilia in women with severe ovarian hyperstimulation syndrome and cost-effectiveness of screening. Fertil Steril 81:989–995

    Article  PubMed  Google Scholar 

  33. Dulitzky M, Cohen SB, Inbal A et al. (2002) Increase prevalence of thrombophilia among women with severe ovarian hyperstimulation syndrome. Fertil Steril 77:463–467

    Article  PubMed  Google Scholar 

  34. Grandone E, Colaizzo D, Lo Bue A et al. (2001) Inherited thrombophilia and in-vitro fertilization implantation failure. Fertil Steril 76:201–202

    Article  PubMed  CAS  Google Scholar 

  35. Qublan HS, Eid SS, Ababneh HA et al. (2006) Acquired and inherited thrombophilia: implication in recurrent IVF and embryo transfer failure. Hum Reprod 21:2694–2698

    Article  PubMed  CAS  Google Scholar 

  36. Martinelli I, Taioli E, Ragni G et al. (2003) Embryo implantation after assisted reproductive procedures and maternal thrombophilia. Haematologica 88:789–793

    PubMed  Google Scholar 

  37. Coulam CB, Jeyendran RS, Fishel LA, Roussev R (2006) Multiple thrombophilic gene mutations are risk factors for implantation failure. Reprod Biomed Online 12:322–327

    Article  PubMed  Google Scholar 

  38. Miyakis S, Lockshin MD, Atsumi T et al. (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4:295–306

    Article  PubMed  CAS  Google Scholar 

  39. Le Thi Huong D, Wrchsler B, Piette JC (2003) Ovulation induction therapy and systemic lupus erythematosus. Ann Med Interne (Paris) 154:45–50

    Google Scholar 

  40. Bellver J, Pellicer A (2009) Ovarian stimulation for ovulation induction and in-vitro fertilization in patients with systemic lupus erythematosus and antiphospholipid syndrome. Fertil Steril 92:1803–1810

    Article  PubMed  Google Scholar 

  41. El-Shawarby SA, Margara RA, Trew GH et al. (2004) Thrombocythemia and hemoperitoneum after transvaginal oocyte retrieval for in-vitro fertilization. Fertil Steril 82:735–737

    Article  PubMed  Google Scholar 

  42. Ricci G, Cerneca F, Simeone R et al. (2004) Impact of highly purified urinary FSH and recombinant FSH on haemostasis: an open-label, randomized, controlled trial. Hum Reprod 19:838–848

    Article  PubMed  CAS  Google Scholar 

  43. Shulman A (2006) Safety of IVF under anticoagulant therapy in patients at risk for thrombo-embolic events. Reprod Biomed Online 12:354–358

    Article  PubMed  Google Scholar 

  44. Edris F, Kerner CM, Feyles V et al. (2007) Successful management of an extensive intracranial sinus thrombosis in a patient undergoing IVF: case report and review of literature. Fertil Steril 88:705.e9-14

    Article  PubMed  Google Scholar 

  45. Cupisti S, Mueller A, Strauss R et al. (2007) Severe ovarian hyperstimulation syndrome in a twin pregnancy after intracytoplasmic sperm injection. J Obstet Gynaecol Res 33:585–589

    Article  PubMed  Google Scholar 

  46. Chipwete SE, Bugren S, Rafla N (2009) Thrombosis post ovarian hyperstimulation. Fertil Steril 91: 1956.e13–e14

    Google Scholar 

  47. Yinon Y, Pauzner R, Dulitzky M et al. (2006) Safety of IVF under anticoagulant therapy in patients at risk for thrombo-embolic events. Reprod Biomed Online 12:354–358

    Article  PubMed  Google Scholar 

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  1. H. Conard
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Conard, H. (2011). Implications des pathologies hématologiques sur l’assistance médicale à la procréation. In: Physiologie, pathologie et thérapie de la reproduction chez l’humain. Springer, Paris. https://doi.org/10.1007/978-2-8178-0061-5_55

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  • DOI: https://doi.org/10.1007/978-2-8178-0061-5_55

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0060-8

  • Online ISBN: 978-2-8178-0061-5

  • eBook Packages: MedicineMedicine (R0)

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