Skip to main content
SpringerLink
Log in

Stratégies anti-hyperalgésiques dans la prévention des douleurs chroniques post-chirurgicales : données précliniques et application clinique

  • Chapter
La douleur chronique post-chirurgicale

  • 720 Accesses

Résumé

Au regard de sa définition par l’IASP („une expérience sensorielle et émotionnelle désagréable, associée à des lésions tissulaires réelles ou potentielles, ou décrite en termes de tels dommages“), la douleur ne peut et ne doit pas être considérée comme une simple réponse à un stimulus nociceptif, mais est aussi l’expression conjointe de l’histoire de l’individu et de ses relations avec l’environnement [1], associée aux processus de plasticité que le système nerveux central met en place et utilise pour répondre de façon adaptée aux stimuli nociceptifs. Il a ainsi été montré que la plasticité inhérente au système nerveux central module physiologiquement la transmission de l’information nociceptive [2]. La sensation douloureuse relève alors d’un subtil équilibre entre l’activité de systèmes inhibiteurs (antinociceptifs) et de systèmes facilitateurs (pronociceptifs) de la nociception [3]. L’activation de ces derniers reposerait plus particulièrement sur la mise en jeu de processus de sensibilisation dont on sait aujourd’hui qu’ils sont responsables d’une majoration de la douleur post-opératoire à travers l’expression d’une hyperalgésie.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Références

  1. Watkins LR, Cobelli DA, Mayer DJ (1982) Classical conditioning of front paw and hind paw footshock induced analgesia (FSIA): naloxone reversibility and descending pathways. Brain Res 243: 119–32

    Article  PubMed  CAS  Google Scholar 

  2. Woolf CJ, Salter MW (2000) Neuronal plasticity: increasing the gain in pain. Science 288: 1765–9

    Article  PubMed  CAS  Google Scholar 

  3. Fields HL (2000) Pain modulation: expectation, opioid analgesia and virtual pain. Prog Brain Res 122: 245–53

    Article  PubMed  CAS  Google Scholar 

  4. Coderre TJ, Katz J, Vaccarino AL, Melzack R (1993) Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 52: 259–85

    Article  PubMed  CAS  Google Scholar 

  5. Latremoliere A, Woolf CJ (2009) Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain 10: 895–926

    Article  PubMed  Google Scholar 

  6. Abbadie C, Banghoo S, De Koninck Y, et al. (2009) Chemokines and pain mechanisms. Brain Res Rev 60: 125–34

    Article  PubMed  CAS  Google Scholar 

  7. Negri L, Lattanzi R, Giannini E, et al. (2009) Bv8/prokineticins and their receptors: a new pronociceptive system. Int Rev Neurobiol 85: 145–57

    Article  PubMed  CAS  Google Scholar 

  8. Obata H, Eisenach JC, Hussain H, et al. (2006) Spinal glial activation contributes to postoperative mechanical hypersensitivity in the rat. J Pain 7: 816–22

    Article  PubMed  CAS  Google Scholar 

  9. Hurley RW, Hammond DL (2001) Contribution of endogenous enkephalins to the enhanced analgesic effects of supraspinal mu opioid receptor agonists after inflammatory injury. J Neurosci 21: 2536–45

    PubMed  CAS  Google Scholar 

  10. Laprairie JL, Murphy AZ (2009) Neonatal injury alters adult pain sensitivity by increasing opioid tone in the periaqueductal gray. Frontiers in Behavioral Neuroscience 3: 1–11

    Article  Google Scholar 

  11. Rivat C, Laulin JP, Corcuff JB, et al. (2002) Fentanyl enhancement of carrageenan-induced long-lasting hyperalgesia in rats: prevention by the N-methyl-d-aspartate receptor antagonist ketamine. Anesthesiology 96: 381–91

    Article  PubMed  CAS  Google Scholar 

  12. Rivat C, Laboureyras E, Laulin JP, et al. (2007) Non-nociceptive environmental stress induces hyperalgesia, not analgesia, in pain and opioid-experienced rats. Neuropsychopharmacology 32: 2217–28

    Article  PubMed  CAS  Google Scholar 

  13. Célèrier E, Rivat C, Jun Y, et al. (2000) Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine. Anesthesiology 92: 465–72

    Article  PubMed  Google Scholar 

  14. Richebe P, Rivat C, Laulin JP, et al. (2005) Ketamine improves the management of exaggerated postoperative pain observed in perioperative fentanyl-treated rats. Anesthesiology 102: 421–8

    Article  PubMed  CAS  Google Scholar 

  15. Guignard B, Bossard AE, Coste C, et al. (2000) Acute opioid tolerance: intraoperative remifentanil increases postoperative pain and morphine requirement. Anesthesiology 93: 409–17

    Article  PubMed  CAS  Google Scholar 

  16. Joly V, Richebe P, Guignard B, et al. (2005) Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine. Anesthesiology 103: 147–55

    Article  PubMed  CAS  Google Scholar 

  17. Ossipov MH, Lai J, Vanderah TW, Porreca F (2003) Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance. Life Sci 73: 783–800

    Article  PubMed  CAS  Google Scholar 

  18. Rivat C, Vera-Portocarrero LP, Ibrahim MM, et al. (2009) Spinal NK-1 receptorexpressing neurons and descending pathways support fentanyl-induced pain hypersensitivity in a rat model of postoperative pain. Eur J Neurosci

    Google Scholar 

  19. Quartilho A, Mata HP, Ibrahim MM, et al. (2004) Production of paradoxical sensory hypersensitivity by alpha 2-adrenoreceptor agonists. Anesthesiology 100: 1538–44

    Article  PubMed  CAS  Google Scholar 

  20. Gardell LR, Burgess SE, Dogrul A, et al. (2002) Pronociceptive effects of spinal dynorphin promote cannabinoid-induced pain and antinociceptive tolerance. Pain 98: 79–88

    Article  PubMed  CAS  Google Scholar 

  21. Kehlet H, Jensen TS, Woolf CJ (2006) Persistent postsurgical pain: risk factors and prevention. Lancet 367: 1618–25

    Article  PubMed  Google Scholar 

  22. Banik RK, Subieta AR, Wu C, Brennan TJ (2005) Increased nerve growth factor after rat plantar incision contributes to guarding behavior and heat hyperalgesia. Pain 117: 68–76

    Article  PubMed  CAS  Google Scholar 

  23. Mantyh P, Tive L, Shelton D (2009) Tanezumab, a humanized anti-nerve growth factor antibody for the treatment of pain. J Pain 10: S44

    Google Scholar 

  24. Hayashida K, Parker R, Eisenach JC (2007) Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. Anesthesiology 106: 1213–9

    Article  PubMed  CAS  Google Scholar 

  25. Van Elstraete AC, Sitbon P, Mazoit JX, Benhamou D (2008) Gabapentin prevents delayed and long-lasting hyperalgesia induced by fentanyl in rats. Anesthesiology 108: 484–94

    Article  PubMed  Google Scholar 

  26. Hara K, Sata T (2007) Inhibitory effect of gabapentin on N-methyl-d-aspartate receptors expressed in Xenopus oocytes. Acta Anaesthesiol Scand 51: 122–8

    Article  PubMed  CAS  Google Scholar 

  27. Curtin LI, Grakowky JA, Suarez M, et al. (2009) Evaluation of buprenorphine in a postoperative pain model in rats. Comp Med 59: 60–71

    PubMed  CAS  Google Scholar 

  28. Jevtovic-Todorovic V, Todorovic SM, Mennerick S, et al. (1998) Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin. Nat Med 4: 460–3

    Article  PubMed  CAS  Google Scholar 

  29. Richebe P, Rivat C, Creton C, et al. (2005) Nitrous oxide revisited: evidence for potent antihyperalgesic properties. Anesthesiology 103: 845–54

    Article  PubMed  CAS  Google Scholar 

  30. Bessiere B, Richebe P, Laboureyras E, et al. (2007) Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioidexperienced rats. Neuropharmacology 53: 733–40

    Article  PubMed  CAS  Google Scholar 

  31. Bessiere B, Laboureyras E, Chateauraynaud J, et al. (2009) A Single Nitrous Oxide (N(2)O) Exposure Leads to Persistent Alleviation of Neuropathic Pain in Rats. J Pain

    Google Scholar 

  32. Verleye M, Andre N, Heulard I, Gillardin JM (2004) Nefopam blocks voltagesensitive sodium channels and modulates glutamatergic transmission in rodents. Brain Res 1013: 249–55

    Article  PubMed  CAS  Google Scholar 

  33. Girard P, Pansart Y, Coppe MC, Gillardin JM (2001) Nefopam reduces thermal hypersensitivity in acute and postoperative pain models in the rat. Pharmacol Res 44: 541–5

    Article  PubMed  CAS  Google Scholar 

  34. Laboureyras E, Chateauraynaud J, Richebe P, Simonnet G (2009) Long-term pain vulnerability after surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic properties. Anesth Analg 109: 623–31

    Article  PubMed  CAS  Google Scholar 

  35. Himmelseher S, Durieux ME (2005) Ketamine for perioperative pain management. Anesthesiology 102: 211–20

    Article  PubMed  Google Scholar 

  36. Elia N, Tramer MR (2005) Ketamine and postoperative pain—a quantitative systematic review of randomised trials. Pain 113: 61–70

    Article  PubMed  CAS  Google Scholar 

  37. Roytblat L, Korotkoruchko A, Katz J, et al. (1993) Postoperative pain: the effect of low-dose ketamine in addition to general anesthesia. Anesth Analg 77: 1161–5

    Article  PubMed  CAS  Google Scholar 

  38. Stubhaug A, Breivik H, Eide PK, et al. (1997) Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery. Acta Anaesthesiol Scand 41: 1124–32

    Article  PubMed  CAS  Google Scholar 

  39. Warncke T, Stubhaug A, Jorum E (1997) Ketamine, an NMDA receptor antagonist, suppresses spatial and temporal properties of burn-induced secondary hyperalgesia in man: a double-blind, cross-over comparison with morphine and placebo. Pain 72: 99–106

    Article  PubMed  CAS  Google Scholar 

  40. (2009) Expert panel guidelines (2008). Postoperative pain management in adults and children. SFAR Committees on Pain and Local Regional Anaesthesia and on Standards. Ann Fr Anesth Reanim 28: 403–9

    Google Scholar 

  41. De Kock M, Lavand’homme P, Waterloos H (2001) ‚Balanced analgesia ‘in the perioperative period: is there a place for ketamine? Pain 92: 373–80

    Article  PubMed  Google Scholar 

  42. Duale C, Sibaud F, Guastella V, et al. (2009) Perioperative ketamine does not prevent chronic pain after thoracotomy. Eur J Pain 13: 497–505

    Article  PubMed  CAS  Google Scholar 

  43. Ho KY, Gan TJ, Habib AS (2006) Gabapentin and postoperative pain—a systematic review of randomized controlled trials. Pain 126: 91–101

    Article  PubMed  CAS  Google Scholar 

  44. Brogly N, Wattier JM, Andrieu G, et al. (2008) Gabapentin attenuates late but not early postoperative pain after thyroidectomy with superficial cervical plexus block. Anesth Analg 107: 1720–5

    Article  PubMed  CAS  Google Scholar 

  45. De Kock M, Lavand’homme P, Waterloos H (2005) The short-lasting analgesia and long-term antihyperalgesic effect of intrathecal clonidine in patients undergoing colonic surgery. Anesth Analg 101: 566–72, table of contents

    Article  PubMed  Google Scholar 

  46. Koppert W, Ihmsen H, korber N, et al. (2005) Different profiles of buprenorphineinduced analgesia and antihyperalgesia in a human pain model. Pain 118: 15–22

    Article  PubMed  CAS  Google Scholar 

  47. Wehrfritz AP, Richebe P, Noel N, et al. (2009) A randomized phase I trial evaluating the anti-hyperalgesic and analgesic effects of 50%-50% N2O−O2. Annual Meeting of American Society of Anesthesiologists New Orleans, LA, United States: 17–21 octobre

    Google Scholar 

  48. Kapfer B, Alfonsi P, Guignard B, et al. (2005) Nefopam and ketamine comparably enhance postoperative analgesia. Anesth Analg 100: 169–74

    Article  PubMed  Google Scholar 

  49. Tirault M, Derrode N, Clevenot D, et al. (2006) The effect of nefopam on morphine overconsumption induced by large-dose remifentanil during propofol anesthesia for major abdominal surgery. Anesth Analg 102: 110–7

    Article  PubMed  CAS  Google Scholar 

  50. Picard W, Richebe P, Pouquet O, et al. (2008) Nefopam reduces postoperative hyperalgesia after cardiac surgery. Annual Meeting of American Society of Anesthesiologists Orlando, Florida: 18–22 octobre

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anesthesiology and Pain Medicine Seattle, University of Washington, États-Unis

    C. Rivat & P. Richebe

Authors
  1. C. Rivat
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Richebe
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C. Rivat .

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Paris

About this chapter

Cite this chapter

Rivat, C., Richebe, P. (2013). Stratégies anti-hyperalgésiques dans la prévention des douleurs chroniques post-chirurgicales : données précliniques et application clinique. In: La douleur chronique post-chirurgicale. Springer, Paris. https://doi.org/10.1007/978-2-8178-0026-4_10

Download citation

  • DOI: https://doi.org/10.1007/978-2-8178-0026-4_10

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0025-7

  • Online ISBN: 978-2-8178-0026-4

Publish with us

Policies and ethics

Search

Navigation