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Les principaux agents et techniques d’analgésie par voie systémique

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Analgésie et sédation en réanimation

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À ce jour, aucun agent ne possède toutes les qualités requises (bonne tolérance hémodynamique et respiratoire, absence d’accumulation dans l’organisme, amnésie, anxiolyse) pour assurer une sédation et une analgésie idéale (1). Le choix des différents agents isolés ou en association répond à des critères d’analyse de la balance entre les bénéfices et les risques escomptés. L’usage consiste à associer un agent hypnotique et un analgésique. Le propofol et le midazolam sont les hypnotiques les plus utilisés en France. Parmi les opiacés, le rémifentanil possède l’avantage unique d’avoir une demi-vie d’élimination indépendante de la durée d’administration. La pharmacocinétique des agents utilisés pour la sédation analgésie est cependant profondément modifiée la plupart du temps chez les patients de réanimation.

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Argo, V., Bonnet, F. (2010). Les principaux agents et techniques d’analgésie par voie systémique. In: Analgésie et sédation en réanimation. Le point sur .... Springer, Paris. https://doi.org/10.1007/978-2-287-99029-8_2

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  • DOI: https://doi.org/10.1007/978-2-287-99029-8_2

  • Publisher Name: Springer, Paris

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