Resume
À ce jour, aucun agent ne possède toutes les qualités requises (bonne tolérance hémodynamique et respiratoire, absence d’accumulation dans l’organisme, amnésie, anxiolyse) pour assurer une sédation et une analgésie idéale (1). Le choix des différents agents isolés ou en association répond à des critères d’analyse de la balance entre les bénéfices et les risques escomptés. L’usage consiste à associer un agent hypnotique et un analgésique. Le propofol et le midazolam sont les hypnotiques les plus utilisés en France. Parmi les opiacés, le rémifentanil possède l’avantage unique d’avoir une demi-vie d’élimination indépendante de la durée d’administration. La pharmacocinétique des agents utilisés pour la sédation analgésie est cependant profondément modifiée la plupart du temps chez les patients de réanimation.
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References
Young C, Knudsen N, Hilton A, Reves JG (2002) Sedation in the intensive care unit. Crit Care Med 28: 854–66
Kay B, Rolly G ICI 35868 (1977) A new intravenous induction agent. Acta Anaesthesiol Belg 28: 303
Albanese J, Martin C, Lacarelle B et al. (1990) Pharmacokinetics of long-term propofol infusion used for sedation in ICU patients. Anesthesiology 73: 214–7
Barr J, Egan TD, Sandoval NF et al. (2000) Propofol dosing regimens for ICU sedation based upon an integrated pharmacokinetic-pharmacodynamic model, Anesthesiology 195:324–3
Fudickar A, Bein B (2009) Propofol infusion syndrome: update of clinical manifestation and pathophysiology. Minerva Anestesiol. 75: 339–44
Vasile B, Rasulo F, Candiani A, Latronico N (2003) The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome, Intensive Care Med 29: 1417–25
Wysowski DK, Pollock ML (2006) Reports of death with use of propofol (Diprivan®) for non-procedural (long-term) sedation and literature review, Anesthesiology 105: 1047–51
Payen J F, Chanques G, Mantz J B et al. (2007) Current practice in sedation and analgesia for mechanically ventilated critically ill patients: a prospective multicenter patient based study. Anesthesiology 106: 687–95
Ostermann ME, Keenan S P, Seiferling RA, Sibbald WJ (2000) Sedation in the intensive care unit: a systematic review, JAMA 283: 1451–9
Walder B, Elia N, Henzi I et al. (2001) A lack of evidence of superiority of propofol versus midazolam for sedation in mechanically ventilated critically ill patients: a qualitative and quantitative systematic review. Anesth Analg 92: 975–83
McMurray TJ, Johnston JR, Milligan KR et al. (2004) Propofol sedation using diprifusor target-controlled infusion in adult intensive care unit patients. Anaesthesia 59: 636–41
Hall RI, Sandham D, Cardinal P et al. (2001) Propofol vs midazolam for ICU sedation: a Canadian multicenter randomized trial. Chest 119: 1151–9
Kress J, Pohlman A, O’Connor M, Hall J (2000) Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 342: 1471–7
Macdonald JF, Nowak LM (1990) Mechanisms of blockade of excitatory amino acid receptor channels. Trends Pharmocol Sci 11: 167–72
Chudnofsky CR, Weber JE, Stoyanoff PJ et al. (2000) A combination of midazolam and ketamine for procedural sedation and analgesia in adult emergency department patients. Acad Emerg M 7: 863–80
Elia N, Tramer MR (2005) Ketamine and postoperative pain. A quantitative systematic review of randomized trials. Pain 113: 61–70
Clements JA, Nimmo WS (1981) Pharmacokinetics and analgesic effect of ketamine in man. Br J Anaesth 53: 27–30
De Pinto M, Jelacic J, Edwards WT (2008) Very-low-dose ketamine for the management of pain and sedation in the ICU J Opioid Manag 4: 54–6
Maze M, Bonnet F (2003) Receptor ligands a2 adrenergic receptor agonists. In Pharmacology basis of clinical practice. Maze M ed, Londres 473–89
Ip Yam PC, Forbes A, Kox WJ (1992) Clonidine in the treatment of alcohol withdrawal in the intensive care unit. Br J Anaesth. Jan; 68: 106–8
Pandharipande P P, Pun BT, Herr DL (2007) Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA. 298: 2644–53
Shehabi V, Ruettimann U, Adamson H et al. (2004) Dexmedetomidine infusion for more than 24 hours in critically ill patients: sedative and cardiovascular effects. Intensive Care Med 30: 2188–96
Gerlach AT, Dasta Joseph F (2007) Dexmedetomidine: an Updated Review. The Annals of Pharmacotherapy. Feb; 41: 245–53
Nunes S, Kaukonen M, Shepherd ST (2009) Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation. Intensive Care Med 35: 282–90
Riker R, Shehabi Y, Bokesch PM (2009) Dexmedetomidine vs Midazolam for Sedation of Critically Ill Patients. JAMA. 31: 489–99
Milbrandt EB, Kersten A, Kong L et al. (2005) Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients. Crit Care Med. 33: 226–9
Osborne R, Joel S, Grebenik T et al. (1993) The pharmacokinetics of morphine and morphine glucuronides in kidney failure. Clin Pharmacol Ther 54: 158–67
Murdoch S, Cohen A (2000) Intensive care sedation: a review of current British practices. Intensive Care Med 26: 922–8
Kapila A, Glass PSA, Jacobs JR et al. (1995) Measured context-sensitive half-times of remifentanil and alfentanil. Anesthesiology 83: 968–75
Rozendaal FW, Spronk PE, Snellen FF, Schoen A (2009) Remifentanil-propofol analgo-sedation shortens duration of ventilation and length of ICU stay compared to a conventional regimen: a centre randomised, cross-over, open-label study in the Netherlands. Intensive Care Med 35: 291–8
Minto CF, Schnider TW, Egan TD et al. (1997) Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil. I. Model development. Anesthesiology 86: 10–23
Carle CE, Goodall J (2009) Optimal dose and timing for perioperative morphine after remifentanil-based anaesthesia. Br J Hosp Med 70: 177
Viscusi ER, Gan TJ, Leslie JB et al. (2009) Peripherally acting mu-opioid receptor antagonists and postoperative ileus: mechanisms of action and clinical applicability. Anesth Analg. 108: 1811–22
Mitra S (2008) Opioid-induced hyperalgesia: pathophysiology and clinical implications. J Opioid Manag 4: 123–30
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Argo, V., Bonnet, F. (2010). Les principaux agents et techniques d’analgésie par voie systémique. In: Analgésie et sédation en réanimation. Le point sur .... Springer, Paris. https://doi.org/10.1007/978-2-287-99029-8_2
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