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Syndrome de Turner avec chromosome Y

  • Jérôme Couturier

Abstrait

Le syndrome de Turner et, plus généralement, les dysgénésies gonadiques avec présence d’un chromosome Y au caryotype constitutionnel prédisposent principalement au risque de gonadoblastome (1, 2). Il s’agit d’une tumeur bénigne, bilatérale dans 10 à 30 % des cas, à fort potentiel de transformation maligne. Ces tumeurs sont composées d’un contingent de cellules germinales dans un stroma formé d’éléments des cordons sexuels, cellules de Sertoli, de la granulosa (3). La prolifération maligne du contingent germinal est à l’origine de dysgerminomes (séminomes).

Références

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Copyright information

© Springer-Verlag France 2009

Authors and Affiliations

  • Jérôme Couturier
    • 1
  1. 1.Service de génétique oncologiqueInstitut CurieParis Cedex 05

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