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Lymphomes T cutanés (hors mycosis fongoïde et syndrome de Sézary)

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Manifestations dermatologiques des maladies du système hématopoïétique et oncologie dermatologique

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Abstrait

Les lymphomes cutanés primitifs (LCP) constituent le deuxième groupe de lymphomes extraganglionnaires après les lymphomes digestifs. Ces proliférations d’origine T(80%) ou B lymphocytaire ont une histoire clinique différente de celle de lymphomes ganglionnaires de même type histologique dont il est important de les distinguer. Cela rend ici nécessaire la réalisation d’un bilan d’extension pour affirmer leur nature cutanée primitive. Le groupe de l’EORTC (European Organisation for Research and Treatment of Cancer) dirigé par Willemze a élaboré en 1997 une classification tenant compte des particularités anatomocliniques et évolutives de ces lymphomes àpoint de départ cutané, informative pour le diagnostic et le pronostic et donc pour la prise en charge des patients, et pouvant aussi, àterme, s’avérer utile pour la compréhension de la pathogénie des différents sous-groupes. Cette démarche a eu le mérite d’identifier des entités spécifiques aux LCP qui ont été intégrées dans la récente classification de l’Organisation mondiale de la santé (OMS = WHO) et a servi de base àune classification commune consensuelle EORTC-WHO récemment proposée pour les lymphomes cutanés, qui intègre aussi de nouvelles entités identifiées depuis la classification initiale des LCP de l’EORTC telles que les lymphomes épidermotropes agressifs CD8+ ou les proliférations CD4+CD56+ et démembre le groupe des lymphomes sous-cutanés (encadré 52.A).

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Références

  1. Willemze R, Kerl H, Sterry W et al. EORTC classification for primary cutaneous lymphonas: a proposal for research and treatment of cancer. Blood 1997; 90:354–371.

    PubMed  CAS  Google Scholar 

  2. Fink-Puches R, Zenahlik R, Back B et al. Primary cutaneous lymphomas: applicability of current classification schemes (EORTC, WHO) based on clinicopathoiogic features observed in a large group of patients. Blood 2002; 99:800–805.

    Article  PubMed  CAS  Google Scholar 

  3. Harris NL, Jaffe ES, Diebold J et al. The World Health Organization classification of neplastic diseases of haernatopoeietic and lymphoid tissues. Histopathology 2000; 36:69–86.

    Article  PubMed  CAS  Google Scholar 

  4. Willemze R, Jaffe ES, Burg G et al. WHO-EORTC classification for cutaneous lymphomas. Blood 2005; 105:3768–3785.

    Article  PubMed  CAS  Google Scholar 

  5. Grange F, Hedelin G, Joly P et al. Prognostic factors in primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome. Blood 1999; 93:3637–3642.

    PubMed  CAS  Google Scholar 

  6. Bekkenk MW, Geelen FA, van Voorst Vader PC et al. Primary and secondary cutaneous CD30+ lymphoproliferative disorders: a report from Dutch Cutaneous lymphoma Group on the long-term follow up data of 219 patients and guidelines for diagnosis and treatment. Blood 2000; 95:3653–3661.

    PubMed  CAS  Google Scholar 

  7. Beljaards RC, Kaudewitz P, Berti E et al. Primary cutaneous CD30-positive large cell lymphoma: definition of a new type of cutaneous lymphoma with favorable prognosis. An European multicenter study on 47 cases. Cancer 1993; 71:2097 2104.

    Article  PubMed  Google Scholar 

  8. Vergier B, Beylot-Barry M, Pulford K et al for the French Study Group of Cutaneous Lym-phomas. Statistical evaluation of diagnostic and prognostic features of CD30+ cutaneous lymphoproliferative disorders. A clinicopathologic study of 65 cases. Am J SurgPathol 1998; 22:1192 1202.

    Google Scholar 

  9. Vergier B, De Muret A, Beylot-Barry M et al. for the French Study Group on Cutaneous Lymphomas. Transformation of mycosis fungoides: clinicopathological and prognostic features of 45 cases. Blood 2000; 95:2212–2218.

    PubMed  CAS  Google Scholar 

  10. Wood G, Hardman DL, Boni R et al. Lack of the t(2;5) or o ther mutations resulting in expression of anaplastic lymphoma kinase catalytic domain in CD30+primary cutaneous lymphoproliferative disorders and Hodgkin’s disease. Blood 1996; 88:1765–1770.

    PubMed  CAS  Google Scholar 

  11. Beylot-Barry M, Groppi A, Vergier B et al. Characterization of t(2;5) reciprocal transcripts and breakpoints in cutaneous lymphoprolifera-tions. Blood 1998; 91:4668–4676.

    PubMed  CAS  Google Scholar 

  12. Beylot-Barry M, Vergier B, De Mascarel A et al. p53 oncoprotein expression in cutaneous lymphoproliferations. A study of 51 cases. Arch Dermatol 1995; 131:1019–1025.

    Article  PubMed  CAS  Google Scholar 

  13. Lin JIT, Lee JY. Primary cutaneous CD30 anaplastic large cell lymphoma with keratoacan-thoma-like pseudocarcinomatous hyperplasia and marked eosinophilia and neutrophilia. J Cutan Pathol 2004; 31:458–461.

    Article  PubMed  Google Scholar 

  14. Courville P, Wechsler J, Thomine E et al. Pseudoepitheliomatous hyperplasia in cutaneous T cell lymphoma. A clinical, histopatho logical and immunohistochemical study with particular interest in epithelial growth factor expression. Br JDermatol 1999; 140:421–426.

    Article  CAS  Google Scholar 

  15. Burg G, Kempf W, Kazarov DV et al. Pyogenic lymphoma of the skin: a peculiar variant of primary cutaneous neutrophil-rich CD30+ anaplastic large cell lymphoma. Br J Dermatol 2003; 148:580–586.

    Article  PubMed  CAS  Google Scholar 

  16. Liu HL, Hoppe RT, Kohler S et al. CD30+ cutaneous lymphoproliferative disorders: the Stanford experience in lymphomatoid papulo-sis and primary cutaneous anaplastic large cell lymphoma. J Am Acad Dermatol 2003; 49:1049–1058.

    Article  PubMed  Google Scholar 

  17. Prochazkova M, Chevret E, Beylot-Barry M et al. Chromosomal imbalances: a hallmark of tumour relapse in primary cutaneous CD30+ T-cell lymphoma. J Pathol 2003; 201:421–429.

    Article  PubMed  CAS  Google Scholar 

  18. Nijsten T, Curiel Lewandrowski C, Kadin ME. Lymphomatoid papulosis in children: a ret-rospective cohort study of 35 cases. Arch Dermatol 2004; 140:306–312.

    Article  PubMed  Google Scholar 

  19. El-Azhary R, Gibson L, Kurtin P et al. Lymphomatoid papulosis: a clinical and histopatho-logical review of 53 cases with leukocyte im munophenotyping, DNA flow cytometry, and T-cell receptor gene rearrangement studies. J Am Acad Dermatol 1994; 30:210–218.

    Article  PubMed  CAS  Google Scholar 

  20. El Shabrawi-Caelen L, Kerl H, Cerroni L. Lymphomatoid papuiosis. Reappraisal of clinicopathologic presentation and classification into subtypes A, B, C. Arch Dermatol 2004; 140: 441–417.

    Article  Google Scholar 

  21. Beljaards RC, Willemze R. The prognosis of patients with lymphomatoid papulosis associated with malignant lymphomas. Br J Dermatol 1992; 126:596–602.

    Article  PubMed  CAS  Google Scholar 

  22. Zackheim HS, Jones C, Leboit PE et al. Lymphomatoid papulosis associated with mycosis fungoides: a study of 21 patients including analyses for clonality. J Am Acad Dermatol 2003; 49: 620–623.

    Article  PubMed  Google Scholar 

  23. Kempf W. CD30+ lymphoproliferative disorders: histopathology, differential diagnosis, new variants and simulators. J Cutan Pathol 2006;33Sl:58–70.

    Article  Google Scholar 

  24. Beylot-Barry M, Vergier B, Masquelier B et al. The spectrum of cutaneous lymphomas in HIV infection: study of 21 cases. Am J Surg Pathol 1999; 23:1208–1216.

    Article  PubMed  CAS  Google Scholar 

  25. Ravat FE, Spittle ME, Russel-Jones R. primary cutaneous T-cell lymphoma occuring after organ transplantation. J Am Acad Dermatol 2006; 54:668–675.

    Article  PubMed  Google Scholar 

  26. Salhany K, Macon W, Choi J et al. Subcutaneous panniculitis-like T-cell lymphoma: a clinicopathologic, immunophenotypic, and genotypic analysis of alpha/beta and gamma/delat subtypes. Am J Surg Pathol 1998; 22:881–893.

    Article  PubMed  CAS  Google Scholar 

  27. Marzano AV, Berti E, Paulli M et al. Cytophagic histiocytic panniculitis and subcutneous panniculitis-like T-cell lymphoma: report of 7 cases. Arch Dermatol 2000; 136:889–896.

    Article  PubMed  CAS  Google Scholar 

  28. Willemze R, Jansen PM, Cerroni L et al. Subcutaneous panniculitis like T cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases. Blood 2008; 111:838–845.

    Article  PubMed  CAS  Google Scholar 

  29. Toro JR, Liewehr DJ, Pabby N et al. Gamma-Delta T-cell phenotype is associated with significant decreased survival in cutaneous T-cell lymphoma. Blood 2003; 101:3407–3412.

    Article  PubMed  CAS  Google Scholar 

  30. Child FJ, Mitchell TJ, Whittaker SJ et al. Elastic natural killer cell and extranodal natural killer cell-like T-cell lymphoma presenting in the skin. Br J Dermatol 2003; 148:507–515.

    Article  PubMed  CAS  Google Scholar 

  31. Bekkenk MW, Jansen PM, Meijer CJ et al. CD56 + hematological neoplasms presenting in the skin: a retrospective analysis of 23 new cases and 130 cases from the literature. Ann Oncol 2004; 15:1097–1108.

    Article  PubMed  CAS  Google Scholar 

  32. Kerl K, Prins C, Cerroni L et al Regression of extranodal natural killer T-cell lymphoma nasal type with denileukin difitox and bexarotene: report of a case. Br J Dermatol 2006; 154:988–991.

    Article  PubMed  CAS  Google Scholar 

  33. Pagano L, Gallamini A, Trape G et al. NK/T-cell lymphoma nasal type: an Italian multicentrie retrospective survey. Ann Oncol 2006; 17: 794–800.

    Article  PubMed  CAS  Google Scholar 

  34. Magana M, Sangueza P, Gil-Beristain J et al. Angiocentric cutaneous T-cell lymphoma of childhood (hydroa-like lymphoma). J Am Acad Dermatol 1998; 38:574–579.

    Article  PubMed  CAS  Google Scholar 

  35. Berti E, Tomasini D, Vermeer MH et al. Primary cutaneous CD8- positive epidermotropic cytotoxic T cell lymphomas. A distinct clinico-pathological entity with an aggressive clinical behavior. Am J Pathol 1999; 155:483–492.

    PubMed  CAS  Google Scholar 

  36. Marzano AV, Ghislanzoni M, Gianelli U et al Fatal CD8+ epidermotropic cytotoxic primary cutaneous T-cell lymphoma with multiorgan involvement. Dermatology 2005; 211:281–285.

    Article  PubMed  Google Scholar 

  37. Poszepczynska-Guigné E, Jagou M, Wechsler J et al. Lymphome T cutané épidermotrope CD8+ cytotoxique d’évolution très agressive. Ann Dermatol 2006; 133:253–256.

    Google Scholar 

  38. Friedmann D, Wechsler J, Delfau MH et al. Primary cutaneous pleomorphic small T-cell lymphoma. A review of 11 cases. The French Study Group on Cutaneous Lymphomas. Arch Dermatol 1995; 131:1009–1015.

    Article  PubMed  CAS  Google Scholar 

  39. Von den Driesch P, Coors EA. Localized cutaneous small to medium sized pleomorphic T-cell lymphoma: a report of 3 cases stable for years. J Am Acad Dermatol 2002; 43:531–535.

    Google Scholar 

  40. Bekkenk MW, Vermeer MH, Jansen PM et al. Peripheral T-cell lymphomas unspecified presenting in the skin: analysis of prognostic factors in a group of 82 patients. Blood 2003; 102: 2213–2219.

    Article  PubMed  CAS  Google Scholar 

  41. Petrella T, Bagot M, Willemze R etal. Biastic NK cell lymphomas (agranular CD4 + CD56+ hematodermic neoplasms): a review. Am J Clin Pathol 2005; 123:662–675.

    Article  PubMed  Google Scholar 

  42. Kim YM, Willemze R, Pimpinelli N et al TNM classification system for primary cutaneous lymphomas other than mycosis fugoides and Sézary syndrome: a proposal of the International Society of Cutaneous Lymphomas (ISCL) and the Cutaneous Lymphoma Task Force of the European Organization of Research and Treatment of Cancer. Blood 2007; 110: 479–484.

    Article  PubMed  CAS  Google Scholar 

  43. Shehan JM, Kalaaji AN, Markovic SN et al. Management of multifocal primary cutaneous CD30+ anaplastic large cell lymphoma. J Am Acad Dermatol 2004; 51: 103–110.

    Google Scholar 

  44. Vonderheid E, Sajjadian A, Kadin M. Methotrexate as effective therapy for lymphomatoid papulosis and other primary cutaneous CD30+ lymphoproliferative disorders. J Am Acad Dermatol 1996; 34:470–481.

    Article  PubMed  CAS  Google Scholar 

  45. French LE, Shapiro M, Junkins-Hopkins JM et al. Regression of multifocal, skin-restricted, CD30-positive large T-cell lymphoma with interferon alfa and bexarotene therapy. J Am Acad Dermatol 2001; 45:914–918.

    Article  PubMed  CAS  Google Scholar 

  46. Krathen RA, Ward S, Duvic M. Bexarotene is a new treatment option for lymphomatoid papulosis. Dermatology 2003; 206:142–147.

    Article  PubMed  CAS  Google Scholar 

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  1. Service de Dermatologie, Hôpital Haut-Lévøque, 33600, Pessac

    Marie Beylot-Barry (Professeur)

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  1. Marie Beylot-Barry
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Beylot-Barry, M. (2009). Lymphomes T cutanés (hors mycosis fongoïde et syndrome de Sézary). In: Manifestations dermatologiques des maladies du système hématopoïétique et oncologie dermatologique. Springer, Paris. https://doi.org/10.1007/978-2-287-72092-5_4

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  • DOI: https://doi.org/10.1007/978-2-287-72092-5_4

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-287-72091-8

  • Online ISBN: 978-2-287-72092-5

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