Lymphœdèmes des membres

  • Stéphane Vignes

Résumé

Les lymphœdèmes des membres représentent les principales pathologies lymphatiques. Le système lymphatique a pour fonction de réabsorber les liquides et les protéines interstitiels à partir des capillaires lymphatiques initiaux. La captation des protéines est d’autant plus importante que celles-ci sont volumineuses. Au cours des lymphoedèmes, la pression dans les capillaires lymphatiques augmente, faisant apparaître une accumulation de protéines, de liquide interstitiel et de métabolites cellulaires dans l’espace extracellulaire. Survient ensuite une augmentation de la pression osmotique avec comme conséquence un afflux hydrique responsable du lymphoedème. Secondairement, apparaissent un afflux de macrophages stimulant la production de collagène par les fibroblastes, une activation des kératinocytes et des adipocytes. L’évolution se fait donc vers un épaississement et une «fibrose» cutanés.

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© Springer-Verlag France, Paris 2012

Authors and Affiliations

  • Stéphane Vignes

There are no affiliations available

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