Introduction to Cutaneous Melanoma

  • Dirk Schadendorf
  • Corinna Kochs
  • Elisabeth Livingstone


Among all skin cancers, melanoma is the most aggressive, with increasing incidence worldwide and a high potential of metastatic spread. Survival rates in the metastatic stage are poor and therapy is limited. While many aspects of the etiology of melanoma are not yet clearly understood, several risk factors have been described and will be discussed later in this chapter. In the past, therapy options remained limited and were only modestly effective in advanced disease. In recent years, research on melanoma has been progressing rapidly, and genetic and immunologic factors associated with melanoma development and progression have been identified, offering avenues for new therapeutic strategies, including immunomodulating and targeted agents.


Skin Cancer Basal Cell Carcinoma Cutaneous Melanoma Actinic Keratosis TERT Promoter Mutation 
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Copyright information

© Springer Healthcare 2013

Authors and Affiliations

  • Dirk Schadendorf
    • 1
  • Corinna Kochs
    • 2
  • Elisabeth Livingstone
    • 2
  1. 1.Dermatology, Venereology and AllergologyUniversity Hospital EssenEssenGermany
  2. 2.Department for DermatologyUniversity Hospital EssenEssenGermany

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