Skip to main content
SpringerLink
Log in

Clinical Consequences of the Role of Glutamate and Neuroplasticity in Depressive Disorder

  • Chapter
Neuroplasticity

Abstract

Convergent and compelling data exist showing that glutamatergic modulation forms the basis of the effect of antidepressants in major depressive disorder, through its impact on neuroplasticity. However, a significant part of available information is based on animal studies, preclinical works and clinical research, and therefore this hypothesis has to be challenged at a broader clinical level.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hardy P, Gorwood P: Impact of life events in the course of depression. Encephale 1993; 3:481–489.

    Google Scholar 

  2. Carrion VG, Weems CF, Reiss AL: Stress predicts brain changes in children: a pilot longitudinal study on youth stress, posttraumatic stress disorder, and the hippocampus. Pediatrics 2007;119:509–516.

    Article  PubMed  Google Scholar 

  3. Widom CS, White HR, Czaja SJ, Marmorstein NR: Long-term effects of child abuse and neglect on alcohol use and excessive drinking in middle adulthood. J Stud Alcohol Drugs 2007; 68:317–326.

    PubMed  Google Scholar 

  4. Fish EW, Shahrokh D, Bagot R, et al.: Epigenetic programming of stress responses through variations in maternal care. Ann N Y Acad Sci 2004, 1036:167–180.

    Article  PubMed  Google Scholar 

  5. Champagne DL, Bagot RC, van Hasselt F, et al.: Maternal care and hippocampal plasticity: evidence for experiencedependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress. J Neurosci 2008; 28:6037–6045.

    Article  PubMed  CAS  Google Scholar 

  6. Branchi I, D’Andrea I, Sietzema J, et al.: Early social enrichment augments adult hippocampal BDNF levels and survival of BrdU-positive cells while increasing anxiety-and “depression”-like behavior. J Neurosci Res 2006; 83:965–973.

    Article  PubMed  CAS  Google Scholar 

  7. Buss C, Lord C, Wadiwalla M, et al.: Maternal care modulates the relationship between prenatal risk and hippocampal volume in women but not in men. J Neurosci 2007; 27:2592–2595.

    Article  PubMed  CAS  Google Scholar 

  8. Fuller RW. Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis. Life Sci1994; 55:163–167.

    Article  CAS  Google Scholar 

  9. Watanabe Y, Gould E. Daniels DC, et al.: Tianeptine attenuates stress-induced morphological changes in the hippocampus. Eur J Pharmacol 1992; 222:157–162.

    Article  PubMed  CAS  Google Scholar 

  10. Magariños AM, Deslandes A, McEwen BS: Effects of antidepressant and benzodiazepine treatments on the dendrite structure of CA3 pyramidal neurons after chronic stress. Eur J Pharmacol 1999; 371:113–122.

    Article  PubMed  Google Scholar 

  11. Malberg JE, Eisch AJ, Nestler EJ, Duman RS: Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 2000; 20:9104–9110.

    PubMed  CAS  Google Scholar 

  12. Emery DL, Fulp CT, Saatman KE, et al.: Newly born granule cells in the dentate gyrus rapidly extend axons into the hippocampal CA3 region following experimental brain injury. J Neurotrauma 2005; 22:978–988.

    Article  PubMed  Google Scholar 

  13. McEwen BS, Magarinos AM, Reagan LP: Structural plasticity and tianeptine: cellular and molecular targets. Eur Psychiatry 2002;17(Suppl 3):318–330.

    Article  PubMed  Google Scholar 

  14. Reznikov LR, Grillo CA, Piroli GG, et al.: Acute stress-mediated increases in extracellular glutamate levels in the rat amygdala: differential effects of antidepressant treatment. Eur J Neurosci 2007; 25:3109–3114.

    Article  PubMed  Google Scholar 

  15. Zarate CA Jr, Singh JB, Carlson PJ, et al.: A randomized trial of an N-methyl-d-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry 2006; 63:856–864.

    Article  PubMed  CAS  Google Scholar 

  16. Maeng S, Zarate CA Jr.: The role of glutamate in mood disorders: results from the ketamine in major depression study and the presumed cellular mechanism underlying its antidepressant effects. Curr Psychiatry Rep 2007; 9:467–474.

    Article  PubMed  Google Scholar 

  17. Michael N, Erfurth A, Ohrmann P, et al.: Neurotrophic effects of electroconvulsive therapy: a proton magnetic resonance study of the left amygdalar region in patients with treatment-resistant depression. Neuropsychopharmacology 2003; 28:720–725.

    Article  PubMed  CAS  Google Scholar 

  18. Michael N, Erfurth A, Ohrmann P, et al.: Metabolic changes within the left dorsolateral therapy: a proton magnetic resonance study of the left amgydalar region in patients with treatment-resistent depression. Psychological Medicine 2003; 33:1277–284.

    Article  PubMed  CAS  Google Scholar 

  19. Pfleiderer B, Michael N, Erfurth A, et al: Effective electroconvulsive therapy reverses glutamate/glutamine deficit in the left anterior cingulum of unipolar depressed patients. Psychiatry Research 2003; 122:185–192.

    Article  PubMed  CAS  Google Scholar 

  20. Murck H, Schubert MI, Schmid D, et al.: The glutamatergic system and its relation to the clinical effect of therapeuticsleep deprivation in depression — An MR spectroscopy study. J Psychiatr Res 2008, in press.

    Google Scholar 

  21. May A, Hajak G, Ganssbauer S, et al.: Structural Brain Alterations following 5 Days of Intervention: Dynamic Aspects of Neuroplasticity. Cereb Cortex 2006; 17:205–210.

    Article  PubMed  Google Scholar 

  22. Wang H, Wang X, Scheich H: LTD and LTP induced by transcranial magnetic stimulation in auditory cortex. Neuroreport 1996; 7:521–525.

    Article  PubMed  CAS  Google Scholar 

  23. Langguth B, Kleinjung T, Marienhagen J, et al.: Transcranial magnetic stimulation for the treatment of tinnitus: effects on cortical excitability. BMC Neurosci 2007; 8: 45.

    Article  PubMed  Google Scholar 

  24. Michael N, Gösling M, Reutemann M, et al.: Metabolic changes after repetitive transcranial magnetic stimulation (rTMS) of the left prefrontal cortex: a sham-controlled proton magnetic resonance spectroscopy (1H MRS) study of healthy brain. Eur J Neurosci 2003; 17:2462–2468.

    Article  PubMed  Google Scholar 

  25. Susic V: Potentiation of ketamine effects on the spiking activity in the lateral geniculate nucleus by rapid eye movement (REM) sleep deprivation. Arch Int Physiol Biochim 1976; 84:229–234.

    Article  PubMed  CAS  Google Scholar 

  26. Murck H, Struttmann T, Czisch M, et al.: Increase in amino acids in the pons after sleep deprivation: a pilot study using proton magnetic resonance spectroscopy. Neuropsychobiology 2002; 45:120–123.

    Article  PubMed  CAS  Google Scholar 

  27. Imel ZE, Malterer MB, McKay KM, Wampold BE: A metaanalysis of psychotherapy and medication in unipolar depression and dysthymia. J Affect Disord 2008; 110:197–206.

    Article  PubMed  Google Scholar 

  28. Frewen PA, Dozois DJ, Lanius RA: Neuroimaging studies of psychological interventions for mood and anxiety disorders: empirical and methodological review. Clin Psychol Rev 2008; 28:228–46.

    Article  PubMed  Google Scholar 

  29. Paffenbarger RS, Jr., Lee IM, Leung R: Physical activity and personal characteristics associated with depression and suicide in American college men. Acta Psychiatrica Scandinavica Supplementum 1994; 377:16–22.

    Article  PubMed  Google Scholar 

  30. Ruuskanen JM, Ruoppila I: Physical activity and psychological well-being among people aged 65 to 84 years. Age and Ageing 1995; 24:292–296.

    Article  PubMed  CAS  Google Scholar 

  31. Knubben K, Reischies FM, Adli M, et al.: A randomised, controlled study on the effects of a short-term endurance training programme in patients with major depression. J Sports Med 2007; 41:29–33.

    CAS  Google Scholar 

  32. Mather AS, Rodriguez C, Guthrie MF, et al.: Effects of exercise on depressive symptoms in older adults with poorly responsive depressive disorder: randomised controlled trial. Br J Psychiatry 2002; 180:411–415.

    Article  PubMed  Google Scholar 

  33. Stranahan AM, Khalil D, Gould E: Running induces widespread structural alterations in the hippocampus and entorhinal cortex. Hippocampus 2007; 17:1017–1022.

    Article  PubMed  Google Scholar 

  34. Kessing LV, Andersen PK, Mortensen PB, Bolwig TG: Recurrence in affective disorder. I. Case register study. Br J Psychiatry 1998; 172:23–28.

    Article  PubMed  CAS  Google Scholar 

  35. Sheline YI, Mittler BL, Mintun MA: The hippocampus and depression. Eur Psychiatry 2002; 17(S3):300–305.

    Article  PubMed  Google Scholar 

  36. Campbell S, Marriott M, Nahmias C, MacQueen GM: Lower hippocampal volume in patients suffering from depression: a meta-analysis. Am J Psychiatry 2004; 161(4):598–607.

    Article  PubMed  Google Scholar 

  37. Videbech P, Ravnkilde B: Hippocampal volume and depression: a meta-analysis of MRI studies. Am J Psychiatry 2004; 161:1957–1966.

    Article  PubMed  Google Scholar 

  38. Kendler KS, Thornton LM, Gardner CO: Stressful life events and previous episodes in the etiology of major depression in women: an evaluation of the “kindling” hypothesis. Am J Psychiatry. 2000 Aug;157(8):1243–1251.

    Article  PubMed  CAS  Google Scholar 

  39. Corruble E, Falissard B, Gorwood P: Life events exposure before a treated major depressive episode depends on the number of past episodes. Eur Psychiatry 2006; 22:22–26.

    Google Scholar 

  40. Kronmüller KT, Pantel J, Götz B, et al.: Life events and hippocampal volume in first-episode major depression. J Affect Disord 2008; 110:241–247.

    Article  PubMed  Google Scholar 

  41. Czéh B, Michaelis T, Watanabe T, et al.: Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc Natl Acad Sci U S A 2001; 98:12796–12801.

    Article  PubMed  Google Scholar 

  42. Campbell AM, Park CR, Zoladz PR, et al.: Pre-training administration of tianeptine, but not propranolol, protects hippocampus-dependent memory from being impaired by predator stress. Eur Neuropsychopharmacol 2008;18:87–98.

    Article  PubMed  CAS  Google Scholar 

  43. Gorwood P, Corruble E, Falissard B, Goodwin GM: Toxic effects of depression on brain function: impairment of delayed recall and the cumulative length of depressive disorder in a large sample of depressed outpatients. Am J Psychiatry 2008; 165:731–739.

    Article  PubMed  Google Scholar 

  44. Duman RS, Malberg J, Thome J: Neural plasticity to stress and antidepressant treatment. Biol Psychiatry 1999; 46:1181–1191.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Philip Gorwood
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

J. A. Costa e Silva J. P. Macher J. P. Olié

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Healthcare, a part of Springer Science+Business Media

About this chapter

Cite this chapter

Gorwood, P. (2011). Clinical Consequences of the Role of Glutamate and Neuroplasticity in Depressive Disorder. In: Costa e Silva, J.A., Macher, J.P., Olié, J.P. (eds) Neuroplasticity. Springer, Tarporley. https://doi.org/10.1007/978-1-908517-18-0_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-908517-18-0_5

  • Publisher Name: Springer, Tarporley

  • Print ISBN: 978-1-85873-437-8

  • Online ISBN: 978-1-908517-18-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation