Abstract
The mechanism of atrial fibrillation (AF) is still debatable. Several mechanisms have been proposed and seen in a variety of animal models. A traditional mechanism theory has suggested that AF is maintained by multiple migrating wavelets of re-entrant atrial activation. During AF, the atria contract at a rate of 350–900 beats/min, conducting to the ventricles at a rate of 90–170 beats/min.
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References
Allessie M, Lammers WJEP, Bonke, FIM, Hollen, J. Experimental evaluation of Moe’s multiple wavelet hypothesis of atrial fibrillation. In: Zipes DP, Jalife J (eds), Cardiac Electrophysiology and Arrhythmias. Orlando, FL : Grune & Stratton Inc.; 1985:265-275.
Moe GKRW, Abildskov JA. A computer model of atrial fibrillation. Am Heart J. 964;67:200-220.
Haissaguerre M, Jais P, Shah DC, et al. Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med. 1998;339:659-666.
Mandapati R, Skanes A, Chen J, et al. Stable microreentrant sources as a mechanism of atrial fibrillation in the isolated sheep heart. Circulation. 2000;101:194-199.
S kanes AC, Mandapati R, Berenfeld O, et al. Spatiotemporal periodicity during atrial fibrillation in the isolated sheep heart. Circulation. 1998;98:1236-1248.
E verett IV TH, Olgin JE. Atrial fibrosis and the mechanisms of atrial fibrillation. Heart Rhythm. 2007;4(3 suppl):S24-S27.
Fioranelli M, Piccoli M, Mileto GM, et al. Analysis of heart rate variability five minutes before the onset of paroxysmal atrial fibrillation. Pacing Clin Electrophysiol. 1999;22:743-749.
Herweg B, Dalal P, Nagy B, et al. Power spectral analysis of heart period variability of preceding sinus rhythm before initiation of paroxysmal atrial fibrillation. Am J Cardiol. 1998;82:869-874.
Coumel P. Neural aspects of paroxysmal atrial fibrillation. In: Falk RH, Podrid PJ (eds), Atrial Fibrillation: Mechanisms and Management. New York: Raven Press, 1992:109-125.
Maisel WH. Autonomic modulation preceding the onset of atrial fibrillation. J Am Coll Cardiol. 2003;42:1269-1270.
Fuster V, Rydén LE, Cannom DS, American College of Cardiology Foundation/American Heart Association Task Force, et al. 2011 ACCF/AHA/HRS focused updates incorporated into the ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation. 2011;123:e269-e367.
F rost L, Hune LJ, Vestergaard P. Overweight and obesity as risk factors for atrial fibrillation or flutter: the Danish Diet, Cancer, and Health Study. Am J Med 2005;118:489-495.
Wang TJ, Parise H, Levy D, et al. Obesity and the risk of new-onset atrial fibrillation. JAMA. 2004;292:2471-2477.
Rathore SS, Berger AK, Weinfurt KP, et al. Acute myocardial infarction complicated by atrial fibrillation in the elderly: prevalence and outcomes. Circulation. 2000;101:969-974.
G oldberg RJ, Yarzebski J, Lessard D, et al. Recent trends in the incidence rates of and death rates from atrial fibrillation complicating initial acute myocardial infarction: a communitywide perspective. Am Heart J. 2002;143:519-527.
Prystowsky EN. Tachycardia-induced-tachycardia: a mechanism of initiation of atrial fibrillation. In: DiMarco JP, Prystowsky EN (eds), Atrial Arrhythmias: State of the Art. Armonk, NY : Futura; 1995.
Evans W, Swann P. Lone auricular fibrillation. Br Heart J. 1954;16:194.
Brand FN, Abbott RD, Kannel WB, et al. Characteristics and prognosis of lone atrial fibrillation. 30-year follow-up in the Framingham Study. JAMA. 1985;254:3449-3453.
Brugada R, Tapscott T, Czernuszewicz GZ, et al. Identification of a genetic locus for familial atrial fibrillation. N Engl J Med. 1997;336:905-911.
Fox CS, Parise H, D’Agostino RB Sr, et al. Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring. JAMA. 2004;291:2851-2855.
Ellinor PT, Shin JT, Moore RK, et al. Locus for atrial fibrillation maps to chromosome 6q14–16. Circulation. 2003;107:2880-2883.
Darbar D, Herron KJ, Ballew JD, et al. Familial atrial fibrillation is a genetically heterogeneous disorder. J Am Coll Cardiol. 2003;41:2185-2192.
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Yap, Y.G., Camm, J. (2014). Pathogenesis of Atrial Fibrillation. In: Essentials of Atrial Fibrillation. Springer Healthcare, Tarporley. https://doi.org/10.1007/978-1-907673-98-6_2
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DOI: https://doi.org/10.1007/978-1-907673-98-6_2
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