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Principles of Pulmonary Protection in Heart Surgery pp 251–261Cite as

Benefits of Ultrafiltration for Pulmonary Function

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Abstract

Cardiopulmonary bypass (CPB), using hypothermia with crystalloid hemodilution, is associated with a capillary leak, which results in an increase in tissue water content, manifested as an increase in total body water after cardiac operation.1 Also, CPB induces activation of inflammatory cascades, resulting in activation of neutrophils, platelets, and endothelium,2,3 which release rumor necrosis factor alpha (TNF-α), interleukins (ILs), and other inflammatory mediators.4 Pulmonary injury, induced by an increase in tissue water and activation of the inflammatory reaction, is one of the complications of CPB with a high incidence. This may adversely affect cardiopulmonary interactions after surgery, delaying extubation and discharge from the intensive care unit (ICU).

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  1. Department of Pediatric Thoracic and Cardiovascular Surgery, Shanghai Jiaotong University, School of Medicine, Shanghai Children’s Medical Center, Shanghai, China

    Wei Wang

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  1. Federal University of Sao Paulo, Sao Paulo, 04023900, Brazil

    Edmo Atique Gabriel

  2. University of Miami, 1611 N.W. 12th Avenue, Miami, 33136, Florida, USA

    Tomas Salerno

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Wang, W., Huang, H. (2010). Benefits of Ultrafiltration for Pulmonary Function. In: Gabriel, E., Salerno, T. (eds) Principles of Pulmonary Protection in Heart Surgery. Springer, London. https://doi.org/10.1007/978-1-84996-308-4_27

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