Abstract
Much progress has occurred over the past two decades in cardiac surgery. Innovations abound in the clinical arena, with trends toward less-invasive approaches to ischemic and valvular heart disease and further evolution in techniques of heart transplantation. Despite improvements in techniques, early morbidity and mortality remain high in several procedures, mostly related to cardiopulmonary bypass and cardioplegic arrest.
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References
Nolan SP, Zacour R, Dammann JF. Reflections on the evolution of cardiopulmonary bypass. Ann Thorac Surg. 1997;64:1540-1543.
Murphy GJ, Angelini GD. Side effects of cardiopulmonary bypass: what’s the reality? J Card Surg. 2004;19:481-488.
Paparella D, Yau TM, Young E. Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update. Eur J Cardiothorac Surg. 2002;21:232-244.
Chenoweth DE, Cooper SW, Hugli TE, et al. Complement activation during cardiopulmonary bypass: evidence for generation of C3a and C5a anaphylotoxins. N Engl J Med. 1981;304:497-503.
Fischer WH, Jagels MA, Hugli TE. Regulation of IL-6 synthesis in human peripheral blood mononuclear cells by C3a and C3a (desArg). J Immunol. 1999;162:453-459.
Andersen LW, Landow L, Baek L, et al. Association between gastric intramucosal pH and splanchnic endotoxin, antibody to endotoxin, and TNF-α concentration in patients undergoing cardiopulmonary bypass. Crit Care Med. 1993;21:210-217.
Christman JW, Lancaster LH, Blackwell TS. Nuclear factor κ B: a pivotal role in the systemic inflammatory response syndrome and new target for therapy. Intensive Care Med. 1998;24:1131-1138.
Edmunds LH Jr. Inflammatory response to cardiopulmonary bypass. Ann Thorac Surg. 1998;66:S12-S16.
Ilton MK, Langton PE, Taylor ML, et al. Differential expression of neutrophil adhesion molecule during coronary artery surgery with cardiopulmonary bypass. J Thorac Cardiovasc Surg. 1999;118:930-937.
Jordan JE, Zhao ZQ, Vinten-Johansen J. The role of neutrophils in myocardial ischemia-reperfusion injury. Cardiovasc Res. 1999;43:860-878.
Zahler S, Massoudy P, Hartl H, et al. Acute cardiac inflammatory response to postischemic reperfusion during cardiopulmonary bypass. Cardiovasc Res. 1999;41:722-730.
Wan S, DeSmet JM, Barvais L, et al. Myocardium is a major source of proinflammatory cytokines in patients undergoing cardiopulmonary bypass. J Thorac Cardiovasc Surg. 1996;112:806-811.
Ng CS, Wan S, Yim AP, Arifi AA. Pulmonary dysfunction after cardiac surgery. Chest. 2002;121:1269-1277.
Schlensak C, Doenst T, Preusser S, et al. Bronchial artery perfusion during cardiopulmonary bypass does not prevent ischemia of the lung in piglets: assessment of bronchial artery blood flow with fluorescent microspheres. Eur J Cardiothorac Surg. 2001;19:326-331.
Massoudy P, Zahler S, Becker BF, et al. Evidence for inflammatory responses of the lungs during coronary artery bypass grafting with cardiopulmonary bypass. Chest. 2001;119:31-36.
Siepe M, Goebel U, Mecklenburg A, et al. Pulsatile pulmonary perfusion during cardiopulmonary bypass reduces the pulmonary inflammatory response. Ann Thorac Surg. 2008;86:115-122.
Magnusson L, Zemgulis V, Tehling A, et al. Use of a vital capacity maneuver to prevent atelectasis after cardiopulmonary bypass. Anesthesiology. 1998;88:134-142.
Friedman M, Sellke FW, Wang SY, et al. Parameters of pulmonary injury after total or partial cardiopulmonary bypass. Circulation. 1994;90:262-268.
Naik SK, Knight A, Elliot M. A prospective randomized study of a modified technique of ultrafiltration during pediatric open-heart surgery. Circulation. 1991;84:III422-III431.
Adams DC, Heyer EJ, Simon AE, et al. Incidence of atrial fibrillation after mild or moderate hypothermic cardiopulmonary bypass. Crit Care Med. 2000;28:309-311.
Le Deist F, Menaché P, Kucharsky C, et al. Hypothermia during cardiopulmonary bypass delays but does not prevent neutrophil-endothelial cell adhesion. A clinical study. Circulation. 1995;92:II354-III358.
Mezzetti A, Calafiore AM, Salerno TA, et al. Intermittent antegrade warm cardioplegia reduces oxidative stress and improves metabolism of the ischemic-reperfused human myocardium. J Thorac Cardiovasc Surg. 1995;109:787-795.
Wang J, Liu H, Salerno TA, et al. Does normothermic normokalemic simultaneous antegrade/retrograde perfusion improve myocardial oxygenation and energy metabolism for hypertrophied hearts? Ann Thorac Surg. 2007;83(5):1751-1758.
Conroy BP, Lin CY, Jenkins LW, et al. Hypothermic modulation of cerebral ischemic injury during cardiopulmonary bypass in pigs. Anesthesiology. 1998;88:390-402.
Salerno TA, Panos AL, Tian G, et al. Surgery for cardiac valve and aortic root without cardioplegic arrest (“beating heart”): experience with a new method of myocardial perfusion. J Card Surg. 2007;22:459-464.
Matsumoto Y, Watanabe G, Endo M, et al. Efficacy and safety of on-pump beating heart surgery for valvular disease. Ann Thorac Surg. 2002;74:678-683.
Katircioglu SF, Cicekcioglu F, Tutun U, et al. On-pump beating heart mitral valve surgery without cross-clamping the aorta. J Card Surg. 2008;23:307-311.
Ihnken K, Morita K, Buckberg GD, Salerno TA, et al. The safety of simultaneous arterial and coronary sinus perfusion: experimental background and initial clinical results. J Cardiac Surg. 1994;9:15-25.
Ihnken K, Morita K, Buckberg GD, Salerno TA, et al. Simultaneous arterial and coronary sinus cardioplegic perfusion: an experimental and clinical study. Thorac Cardiovasc Surg. 1994;42(3):141-147.
Wang J, Liu H, Salerno TA, et al. Keeping heart empty and beating improves preservation of hypertrophied hearts for valve surgery. J Thorac Cardiovasc Surg. 2006;132:1314-1320.
Mehlhorn U, Allen SJ, Adams DL, et al. Normothermic continuous antegrade blood cardioplegia does not prevent myocardial edema and cardiac dysfunction. Circulation. 1995;92:1940-1946.
Wan IY, Arifi AA, Wan S, et al. Beating heart revascularization with or without cardiopulmonary bypass: evaluation of inflammatory response in a prospective randomized study. J Thorac Cardiovasc Surg. 2004;127:1624-1631.
Dreyer WJ, Philips SC, Lindsey ML, et al. Interleukin-6 induction in the canine myocardium after cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2000;120:256-263.
Ivey CL, Williams FM, Collins PD, et al. Neutrophil chemoattractants generated in two phases during reperfusion of ischemic myocardium in the rabbit: evidence for a role for C5a and interleukin-8. J Clin Invest. 1995;95:2720-2728.
Angelini GD, Taylor FC, Barnaby CR, et al. Early and midterm outcome after off-pump and on-pump surgery in Beating Heart against Cardioplegic Arrest Studies (BHACAS 1 and 2): a pooled analysis of two randomized controlled trials. Lancet. 2002;359:1194-1199.
Karadeniz U, Erdemli O, Yamak B, et al. On-pump beating heart versus hypothermic arrested heart valve replacement surgery. J Card Surg. 2008;23:107-113.
Ricci M, Macedo FI, Suarez MR, et al. Multiple valve surgery with beating heart technique. Ann. Thorac. Surg 2009; 87: 527-31.
Macedo FI, Carvalho EM, Hassan M, et al. Beating heart valve surgery in patients with low left ventricular ejection fraction. J. Card. Surg. 2010; 25(3):267–271.
Macedo FI, Carvalho EM, Gologorsky E, Salerno T. Lung ventilation/perfusion may reduce pulmonary injury during cardiopulmonary bypass. J. Thorac Cardiovasc Surg. 2010; 139(1): 234-6.
Macedo FI, Carvalho EM, Gologorsky E, et al. Gas Exchange during lung perfusion/ventilation during cardiopulmonary bypass: preliminary results of a pilot study. Open Journal of Cardiovascular Surgery 2010; 3:1-7.
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Salerno, T.A., Macedo, F.I.B., Suarez, M.R., Ricci, M., Gologorsky, E. (2010). Beating Heart Surgery and Pulmonary Ischemia and Reperfusion Injury. In: Gabriel, E., Salerno, T. (eds) Principles of Pulmonary Protection in Heart Surgery. Springer, London. https://doi.org/10.1007/978-1-84996-308-4_15
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DOI: https://doi.org/10.1007/978-1-84996-308-4_15
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