Abstract
Impaired pulmonary function remains a major clinical problem in a variety of settings, such as shock, lung transplantation, and cardiac surgery with cardiopulmonary bypass or circulatory arrest. Pulmonary damage in this context is often associated with ischemia-reperfusion injury, leading to endothelial dysfunction, capillary leakage, and an intense neutrophilic inflammatory response. Clinically, this is recognized as a progressive deterioration in gas exchange, opacification of the chest X-ray, and increased pulmonary vascular resistance.1
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Donndorf, P., Kaminski, A., Steinhoff, G. (2010). The Role of Nitric Oxide in Pulmonary Ischemia-Reperfusion Injury. In: Gabriel, E., Salerno, T. (eds) Principles of Pulmonary Protection in Heart Surgery. Springer, London. https://doi.org/10.1007/978-1-84996-308-4_12
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