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Dystonia

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Movement Disorders in Clinical Practice

Abstract

Dystonia refers to a group of neurological disorders characterized by spasmodic, patterned, repetitive or sustained co-contractions of agonist and antagonist muscle groups that eventually lead to abnormal twisting movements and postures. The movements range from slow twisting athetoid to rapid myoclonic jerky movements, and may occasionally be accompanied by a tremor [1]. The dystonic movements may be worse with movement (action dystonia), which is either nonspecific or task specific (eg, writer’s cramp) [1].

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References

  1. Warner T. Dystonia. In: Birmingham Movement Disorders course. The Movement Disorder Society, 2008: 267-79.

    Google Scholar 

  2. Greene P. Medical and surgical therapy of idiopathic torsion dystonia. In: Kurlan R (ed.), Treatment of Movement Disorders. Philadelphia: JB Lippincott Co., 1995:153-181.

    Google Scholar 

  3. Jankovic J. Treatment of dystonia. Lancet Neurol 2006;5:864-72.

    Article  CAS  PubMed  Google Scholar 

  4. de Carvalho Aguiar P, Ozelius L. Classification and genetics of dystonia. Review. Lancet Neurol 2002;1:316-25.

    Google Scholar 

  5. Thyagarajan D. Dystonia: recent advances. J Clin Neurosci 1999; 6:1-8.

    Article  PubMed  Google Scholar 

  6. Geyer HL, Bressman SB. The diagnosis of dystonia. Lancet Neurol 2006; 5:780-790.

    Article  PubMed  Google Scholar 

  7. The Epidemiological Study of Dystonia in Europe (ESDE) Collaborative Group. A prevalence study of primary dystonia in eight European countries. J Neurol 2000; 247:787-792.

    Article  Google Scholar 

  8. Matsumota S, Nishimura M, Sbiasski H, Kaji R. Epidemiology of primary dystonia in Japan; comparison with western countries. Mov Disord 2003; 18:1196-1198.

    Article  Google Scholar 

  9. Sheehy MP, Marsden CD. Writer’s cramp - a focal dystonia. Brain 1982; 105:461-80.

    Article  PubMed  Google Scholar 

  10. Blitzer A, Brin M, Fahn S, Lovelace RE. Clinical and laboratory characteristics of focal laryngeal dystonia: study in 110 cases. Laryngoscope 1988; 98:636-641.

    Article  CAS  PubMed  Google Scholar 

  11. Stojanovic M, Cvetkovic D, Kostic VS. A genetic study of idiopathic focal dystonias. J Neurol 1995; 242:508-511.

    Article  CAS  PubMed  Google Scholar 

  12. Fahn S, Bressman SB, Marsden CD. Classification of dystonia. Adv Neurol 1998; 78:1-10.

    CAS  PubMed  Google Scholar 

  13. Gasser T. Inherited myoclonus dystonia syndrome. Adv Neurol 1998; 78:325-334.

    CAS  PubMed  Google Scholar 

  14. Defazio G, Abbruzzese G, Livrea P, Berardelli A. Epidemiology of primary dystonia. Lancet Neurol 2004; 3:673-678.

    Article  PubMed  Google Scholar 

  15. Muller KS, Wenning GK, Seppi K. The prevalence of primary dystonia in the general community. Neurology 2002; 247:787-792.

    Google Scholar 

  16. Segawar M, Hosaka A, Miyagawa F, et al. Hereditary progressive dystonia with marked diurnal fluctuation. Adv Neurol 1976; 14:215-233.

    Google Scholar 

  17. Ichinose H, Ohye T, Takahiashi E, et al. Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase 1 gene. Nat Genet 1994; 8:236-242.

    Article  CAS  PubMed  Google Scholar 

  18. Lee LV, Pascasio FM, Fuentes FD, Viterbo GH. Torsion dystonia in Panay, Philippines. Adv Neurol 1976; 14:137-151.

    CAS  PubMed  Google Scholar 

  19. Kupke KG, Lee L, Mueller U. Assignment of the X-linked torsion dystonia gene to Xq21 by linkage analysis. Neurology 1990; 40:1438-1442.

    CAS  PubMed  Google Scholar 

  20. Brin MF, Jankovic J, Comella C, et al. Treatment of dystonia using botulinum toxin. In: Kurlan R (ed.), Treatment of Movement Disorders. Philadelphia: JB Lippincott Co., 1995; 183-246.

    Google Scholar 

  21. Lal S, Hoyte K, Kiely ME et al. Neuropharmacological investigations and treatment of spasmodic torticollis. Adv Neurol 1979; 24:335.

    CAS  Google Scholar 

  22. Burke RE, Fahn S, Marsden CD. Torsion dystonia: a double blind, prospective trial of high- dosage trihexyphenidil. Neurology 1986; 36:160-164.

    CAS  PubMed  Google Scholar 

  23. Povlsen UJ, Pakkenberg H. effect of intravenous injection of biperiden and clonazepam in dystonia. Mov Disord 1990; 5:27.

    Article  CAS  PubMed  Google Scholar 

  24. Hoon AH, Freese PO, Reinhardt RH, et al. Age-dependent effects of trihexyphenidyl in extrapyramidal cerebral palsy. Pediatr Neurol 2001; 25:55-58.

    Article  PubMed  Google Scholar 

  25. Greene P, Shale H, Fahn S. Analysis of open-label trials in torsion dystonia using high dosages of anticholinergics and other drugs. Mov Disord 1988; 3:46.

    Article  CAS  PubMed  Google Scholar 

  26. Ziegler DK. Prolonged relief of dystonic movements with diazepam. Neurology 1981; 31:1457.

    CAS  PubMed  Google Scholar 

  27. Walker R, Danisi F, Swope D, et al. Intrathecal baclofen for dystonia: benefits and complications during six years of experience. Mov Disord 2000;15:1242-1247.

    Article  CAS  PubMed  Google Scholar 

  28. Hou J-GG, Ondon W, Jankovic J. Intrathecal baclofen for dystonia. Mov Disord 2001; 16:1201-1202.

    Article  CAS  PubMed  Google Scholar 

  29. Naygaard T, Marsden CD, Fahn S. Dopa-responsive dystonia: long term treatment response and prognosis. Neurology 1991;41:174-181.

    Google Scholar 

  30. Greene P, Kange U, Fahn S, et al. Double blind, placebo controlled trial of botulinum toxin injections for the treatment of spasmodic torticollis. Neurology 1990; 40:1213.

    CAS  PubMed  Google Scholar 

  31. Jost W, Blumel J, Grafe S. Botulinum toxin type A free of complexing proteins (XEOMIN) in focal dystonia. Drugs 2007; 67:668-683.

    Article  Google Scholar 

  32. Adam OR, Jankovic J. Treatment of dystonia. Parkinsonism Relat Disord 2007;13 (suppl 3) :S362-368.

    Article  PubMed  Google Scholar 

  33. Krauss JK, Yianni J, Loher TJ, Aziz TZ. Deep brain stimulation for dystonia. J Clin Neurophysiol 2004; 21:18-30.

    Article  PubMed  Google Scholar 

  34. Bertrand C. Selective peripheral denervation for spasmodic torticollis: surgical technique, results and observations in 260 cases. Surg Neurol 1993; 40:96-103.

    Article  CAS  PubMed  Google Scholar 

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Sherman, R., Chaudhuri, K.R. (2010). Dystonia. In: Movement Disorders in Clinical Practice. Springer, London. https://doi.org/10.1007/978-1-84996-065-6_3

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  • DOI: https://doi.org/10.1007/978-1-84996-065-6_3

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