Abstract
In addition to genetics, muscle mass and endocrine factors are major determinants of skeletal mineralization, bone mass, and bone strength. Among the modifiable factors which relevantly influence bone parameters, nutrition plays an important role. Until now, almost all corresponding studies on bone have focused on dietary or hormonal influences alone, thereby considering body size-related factors like BMI, fat mass, or lean body mass either as confounders or as additional potential predictors. However, examinations combining all these three determinants (muscularity, specific hormones, and dietary factors) to evaluate their respective possible contributions to bone status are lacking. Therefore, we studied the potential influences on diaphyseal cortical bone of the muscular component as indexed by muscle area, steroid hormones as quantified in 24-h urine samples, and dietary factors obtained from repeated diet records all combined in healthy children. Regarding nutrition, a special emphasis was placed on dietary alkalinity and protein intake.
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Abbreviations
- 17b-HSD:
-
17b-Hydroxysteroid dehydrogenase
- DHEA:
-
Dehydroepiandrosterone
- NAE:
-
Net acid excretion
- NEAP:
-
Net endogenous acid production
- pQCT:
-
Peripheral quantitative computed tomography
- PRAL:
-
Potential renal acid load
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Remer, T., Libuda, L. (2011). Bone-Anabolic Impact of Dietary High Protein Intake Compared with the Effects of Low Potential Renal Acid Load, Endogenous Steroid Hormones, and Muscularity in Children. In: Burckhardt, P., Dawson-Hughes, B., Weaver, C. (eds) Nutritional Influences on Bone Health. Springer, London. https://doi.org/10.1007/978-1-84882-978-7_27
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DOI: https://doi.org/10.1007/978-1-84882-978-7_27
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